公开(公告)号：US06405230B1

公开(公告)日：2002-06-11

申请号：US09285402

申请日：1999-04-02

申请人： David Charles William Richards ,  John William Richards ,  Paul Anthony Frindle

发明人： David Charles William Richards ,  John William Richards ,  Paul Anthony Frindle

IPC分类号： G06F1710

CPC分类号： H03H17/04

摘要： A method of generating filter coefficients to provide a desired nth order filter response comprises adding one or more substantially co-located pole and zero pairs to form an (n+m)th order filter having the desired nth order filter response.

摘要翻译： 产生滤波器系数以提供期望的第n阶滤波器响应的方法包括添加一个或多个基本上共位的极点和零对以形成具有期望的第n阶滤波器响应的（n + m）阶滤波器。

公开(公告)号：US08609023B1

公开(公告)日：2013-12-17

申请号：US09571989

申请日：2000-05-16

申请人： Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

发明人： Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

IPC分类号： G01N21/00

CPC分类号： G01N35/1002 ,  G01N1/312 ,  G01N35/1016 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/2575

摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of liquid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of liquid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.

摘要翻译： 提供了一种用于自动生物反应系统的方法和装置。 在生物反应系统的处理中，需要将一定量的液体一直放置在载玻片上。 为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。 此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。 除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被移除，并且通过分配器的液体流被简化。 此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。 此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。 提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

公开(公告)号：US08137619B2

公开(公告)日：2012-03-20

申请号：US11234726

申请日：2005-09-23

申请人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Roberta Druyor-Sanchez ,  Bronwen Heilman ,  Wayne Showalter

发明人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Roberta Druyor-Sanchez ,  Bronwen Heilman ,  Wayne Showalter

IPC分类号： G01N21/00 ,  G01N35/00 ,  G01N21/75 ,  G01N1/00

CPC分类号： G01N35/00732 ,  G01N1/31 ,  G01N1/312 ,  G01N35/1002 ,  G01N35/1016 ,  G01N2035/00673 ,  G01N2035/00782 ,  G01N2035/00811 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/2575

摘要： A reagent management system for an automated biological reaction apparatus including an automated biological reaction apparatus including at least one reagent dispenser for applying a reagent to a sample, a memory device containing data for a reagent device selected from the group consisting of a reagent dispenser or a reagent kit used in the automated biological reaction apparatus, a host device comprising a processor and a host device memory connected to the processor, the host memory device including a reagent table, and a scanner for transferring the memory device data to the host device memory.

摘要翻译： 一种用于自动化生物反应装置的试剂管理系统，其包括自动化生物反应装置，其包括至少一个试剂分配器，用于向样品施加试剂;存储装置，其含有试剂装置的数据，所述试剂装置选自试剂分配器或 用于自动生物反应装置中的试剂盒，主机装置，包括处理器和连接到处理器的主机设备存储器，主机存储器装置包括试剂台以及用于将存储器件数据传送到主机设备存储器的扫描器。

公开(公告)号：US20110168744A1

公开(公告)日：2011-07-14

申请号：US13050707

申请日：2011-03-17

申请人： Charles D. Lemme ,  Vincent R. Rizzo, JR. ,  Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

发明人： Charles D. Lemme ,  Vincent R. Rizzo, JR. ,  Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

IPC分类号： B67D7/06

CPC分类号： G01N1/312 ,  G01N35/1002 ,  G01N35/1016 ,  G01N2001/317 ,  G01N2035/1034

摘要： A fluid dispenser comprising a barrel having a reservoir chamber, the barrel having an upper portion, a cap connected to the reservoir chamber, the cap having a surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being adjacent to the reservoir chamber, a coupler having a dispense chamber, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.

摘要翻译： 一种流体分配器，包括具有储存室的桶，所述桶具有上部，连接到储存室的盖，所述盖具有带有至少一个孔的表面，包括偏置构件和孔封闭器的阀， 阀邻近储存室，具有分配室的联接器和位于盖和储存室之间的通风口，排气口包括通气口和由矾土材料构成的排气材料。

公开(公告)号：US07618807B2

公开(公告)日：2009-11-17

申请号：US11863834

申请日：2007-09-28

申请人： Charles Lemme ,  William Richards ,  David Bryant ,  Catherine Wolf ,  Andrew Ghusson ,  Austin Ashby ,  Wayne Showalter ,  Anthony Hartman ,  Brian Kram

发明人： Charles Lemme ,  William Richards ,  David Bryant ,  Catherine Wolf ,  Andrew Ghusson ,  Austin Ashby ,  Wayne Showalter ,  Anthony Hartman ,  Brian Kram

IPC分类号： C12M1/42 ,  C12M3/00

CPC分类号： G01N31/22 ,  A61N1/30 ,  A61N1/325 ,  G01N1/30

摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.

摘要翻译： 本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。 本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。 本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。 典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。 本发明还涉及用于执行该方法的装置。

公开(公告)号：US07396508B1

公开(公告)日：2008-07-08

申请号：US09614401

申请日：2000-07-12

申请人： William Richards ,  Charles D. Lemme ,  Kimberly Christensen ,  Ethel R. Macrea

发明人： William Richards ,  Charles D. Lemme ,  Kimberly Christensen ,  Ethel R. Macrea

IPC分类号： G01N31/00 ,  G01N1/10 ,  G01N35/02 ,  G01N35/10 ,  B01L3/02

CPC分类号： G01N1/312 ,  B01L7/00 ,  G01N15/0255 ,  G01N2035/00366 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/2575

摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on microscope slides are provided. Individualized slide temperature control is accomplished by the heating system according to the present invention that has thermal platforms radially mounted to the carousel for heating the slides and sensing the temperature of each. The heating system also permits automated de-waxing if necessary.

摘要翻译： 提供了用于自动染色或处理安装在显微镜载玻片上的多个组织样品的装置和方法。 个体化的滑块温度控制由根据本发明的加热系统实现，其具有径向安装到转盘上的热平台，用于加热滑块并感测每个的温度。 如果需要，加热系统还允许自动脱蜡。

公开(公告)号：US20070086917A1

公开(公告)日：2007-04-19

申请号：US11558257

申请日：2006-11-09

申请人： Charles LEMME ,  Devon Campbell ,  Andrew Ghusson ,  David Bryant ,  Kurt Reinhardt ,  William Richards ,  Vincent Rizzo ,  Wayne Showalter

发明人： Charles LEMME ,  Devon Campbell ,  Andrew Ghusson ,  David Bryant ,  Kurt Reinhardt ,  William Richards ,  Vincent Rizzo ,  Wayne Showalter

IPC分类号： G01N33/00

CPC分类号： G01N1/312 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/112499 ,  Y10T436/115831 ,  Y10T436/2575

摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions brought to the slides.

摘要翻译： 提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂，洗涤和盖玻片溶液带到载玻片上。 或者，幻灯片保持在固定位置，同时将试剂，洗涤和盖玻片溶液带到载玻片上。

公开(公告)号：US07055381B2

公开(公告)日：2006-06-06

申请号：US10886875

申请日：2004-07-08

申请人： Christopher Gerard Bochkor ,  Paul Anthony Bowers ,  Linda Rozelle Hirschfelt ,  Michael David Marley ,  Michael John Monnot ,  Gary William Richards

发明人： Christopher Gerard Bochkor ,  Paul Anthony Bowers ,  Linda Rozelle Hirschfelt ,  Michael David Marley ,  Michael John Monnot ,  Gary William Richards

IPC分类号： G01M17/02

CPC分类号： G01M17/022

摘要： A laboratory test for general tire durability can produce results comparable to the GM-ATE road test. A passenger tire is mounted in a test machine and run at approximately 50 mph (80 kph), at maximum rated inflation pressure, with at least 100% maximum rated radial load, with approximately 25% of the test duration being performed with lateral force comprised of approximately equal portions of right and left steering, the remainder of the test being performed without lateral force (straight portions). A test segment comprises repeating a loading cycle a plurality of times until approximately 5000 miles have accumulated, and multiple test segments are performed until 16,000 miles have been accumulated. The test is paused and the tire is visually inspected several times during the test segments, including at the end of the test.

公开(公告)号：US20060093520A1

公开(公告)日：2006-05-04

申请号：US11293489

申请日：2005-12-02

申请人： Charles Lemme ,  William Richards ,  Wayne Showalter

发明人： Charles Lemme ,  William Richards ,  Wayne Showalter

IPC分类号： G01N35/00

CPC分类号： G01N1/312 ,  Y10T436/112499 ,  Y10T436/2575

摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent and wash solutions brought to the slides.

摘要翻译： 提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂和洗涤溶液带到载玻片上。

公开(公告)号：US06945128B2

公开(公告)日：2005-09-20

申请号：US09896649

申请日：2001-06-29

申请人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Wayne Showalter ,  Bobbi Druyor-Sanchez ,  Bronwen Heilman ,  Brian McGraw

发明人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Wayne Showalter ,  Bobbi Druyor-Sanchez ,  Bronwen Heilman ,  Brian McGraw

IPC分类号： G01N1/00 ,  A47K5/12 ,  B67D7/06 ,  G01N1/30 ,  G01N1/31 ,  G01N35/00 ,  G01N35/10 ,  B01L3/02

CPC分类号： G01N35/1016 ,  G01N1/312 ,  G01N35/00871 ,  G01N35/1002 ,  G01N2001/317 ,  G01N2035/00881 ,  G01N2035/1034 ,  Y10T137/7873 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/2575

摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.

摘要翻译： 提供了一种用于自动生物反应系统的方法和装置。 在生物反应系统的处理中，需要将一定量的流体一直放置在载玻片上。 为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。 此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。 除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被去除，并且通过分配器的流体流被简化。 此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。 此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。 提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。