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    MANGANESE-BASED MAGNETIC RESONANCE CONTRAST AGENTS
    2.
    发明申请
    MANGANESE-BASED MAGNETIC RESONANCE CONTRAST AGENTS 有权
    基于马格斯的磁共振对比剂

    公开(公告)号：US20150336997A1

    公开(公告)日：2015-11-26

    申请号：US14759114

    申请日：2014-01-07

    申请人： Peter CARAVAN ,  Eirc M. GALE ,  Galen S. LOVING ,  Shereya MUKHERJEE ,  Jiang ZHU

    发明人： Peter Caravan ,  Eric M. Gale ,  Galen S. Loving ,  Shereya Mukherjee ,  Jiang Zhu

    IPC分类号： C07F13/00 ,  A61B5/00 ,  A61B5/055 ,  A61K51/04 ,  A61K49/10

    CPC分类号： C07F13/005 ,  A61B5/0035 ,  A61B5/055 ,  A61K49/06 ,  A61K49/103 ,  A61K49/106 ,  A61K49/14 ,  A61K49/16 ,  A61K51/04 ,  A61K51/0455

    摘要： Manganese coordination complexes with utility as magnetic resonance probes and as biological reductant sensors are disclosed. In one embodiment, ligands can stabilize both the Mn2+ and Mn3+ oxidation states. In the presence of a reductant such as glutathione, low relaxivity MnIII-HBET is rapidly converted to high relaxivity MnII-HBET with a 3-fold increase in relaxivity, and concomitant increase in magnetic resonance signal. In another embodiment, ligands were designed to chelate Mn(ll) in a thermodynamically stable and kinetically inert fashion while allowing for direct interaction of Mn(ll) with water. In yet another embodiment, high molecular weight multimers containing six Mn(ll) chelators were prepared. The high molecular weight results in slower tumbling of the molecules in solution and can strongly enhance the Mn(ll) relaxivity.

    摘要翻译： 公开了作为磁共振探针和生物还原剂传感器的锰配位络合物。 在一个实施方案中，配体可以稳定Mn 2+和Mn 3+氧化态。 在还原剂如谷胱甘肽的存在下，低弛豫MnIII-HBET快速转化为高弛豫度MnII-HBET，松弛度增加3倍，磁共振信号伴随增加。 在另一个实施方案中，设计配体以热力学稳定和动力学惰性的方式螯合Mn（II），同时允许Mn（II）与水直接相互作用。 在另一个实施方案中，制备含有六个Mn（II）螯合剂的高分子量多聚物。 高分子量导致溶液中分子的翻滚较慢，并且可以强烈增强Mn（II）弛豫度。

    System for optimized low power MR imaging
    4.
    发明授权
    System for optimized low power MR imaging 有权

    公开(公告)号：US10012709B2

    公开(公告)日：2018-07-03

    申请号：US13958654

    申请日：2013-08-05

    申请人： Ovidiu Andronesi ,  Bruce Rosen ,  Peter Caravan ,  Himanshu Bhat

    发明人： Ovidiu Andronesi ,  Bruce Rosen ,  Peter Caravan ,  Himanshu Bhat

    IPC分类号： G01V3/00 ,  G01R33/36 ,  G01R33/56 ,  A61B5/055 ,  G01R33/561

    CPC分类号： G01R33/36 ,  A61B5/055 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5617

    摘要： A system acquires MR imaging data of a portion of patient anatomy associated with proton spin lattice relaxation time in a rotating frame using an RF (Radio Frequency) signal generator configured to generate RF excitation pulses and a magnetic field gradient generator configured to generate anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition. The RF signal generator and the gradient generator are configured to provide a rotating frame preparation pulse sequence comprising at least one of, (a) a T1 spin lattice relaxation in a rotating frame (T1ρ) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection and (b) a T2 spin-spin relaxation in a rotating frame (T2ρ) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection.

    Multimodal imaging of fibrin
    5.
    发明授权
    Multimodal imaging of fibrin 有权
    纤维蛋白的多模态成像

    公开(公告)号：US09200017B2

    公开(公告)日：2015-12-01

    申请号：US13256795

    申请日：2010-04-16

    申请人： Peter Caravan

    发明人： Peter Caravan

    IPC分类号： A61K51/00 ,  A61M36/14 ,  C07F9/645 ,  C07F9/40

    CPC分类号： C07F9/645 ,  C07F9/4006

    摘要： Fibrin-specific imaging agents that contain at least two imaging reporters are described, as well as methods of making and using the contrast agents.

    摘要翻译： 描述了含有至少两个成像记录物的纤维蛋白特异性成像剂，以及制造和使用造影剂的方法。

    Fiducial markers and related methods
    6.
    发明授权
    Fiducial markers and related methods 有权
    基准标记及相关方法

    公开(公告)号：US08798716B1

    公开(公告)日：2014-08-05

    申请号：US13288481

    申请日：2011-11-03

    申请人： Danforth S. DeSena ,  Peter Caravan

    发明人： Danforth S. DeSena ,  Peter Caravan

    IPC分类号： A61B5/05 ,  A61B19/00

    CPC分类号： A61B19/54 ,  A61B90/39 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3995

    摘要： In part, the invention relates to fiduciary markers suitable for affixing to a patient that are detectable with respect an imaging modality such as MRI and methods of making the same. The markers include a paramagnetic material disposed therein that generates a distinguishable signal relative to a patient or other biological sample of interest during an imaging data collection session. Further, the markers demonstrate desirable signal to noise ratios across two or more MRI data collection procedures in one embodiment. The length of the markers is also adjustable by, for example, cutting or tearing a substrate upon which a substantially fluid-free region straddles a specified separation position on the substrate.

    摘要翻译： 部分地，本发明涉及适合于固定于病人的受信标记，其可以相对于诸如MRI的成像模态可检测，并且其制造方法。 标记物包括设置在其中的顺磁材料，其在成像数据收集会话期间相对于患者或感兴趣的其他生物样品产生可区分的信号。 此外，在一个实施例中，标记在两个或多个MRI数据收集程序之间表现出期望的信噪比。 标记的长度也可以通过例如切割或撕裂其上基本上无流体的区域横跨基底上的指定分离位置的基底来调节。

    Multimodal Imaging of Fibrin
    7.
    发明申请
    Multimodal Imaging of Fibrin 有权
    纤维蛋白多模态成像

    公开(公告)号：US20120077958A1

    公开(公告)日：2012-03-29

    申请号：US13256795

    申请日：2010-04-16

    申请人： Peter Caravan

    发明人： Peter Caravan

    IPC分类号： C07K7/06 ,  C07K2/00

    CPC分类号： C07F9/645 ,  C07F9/4006

    摘要： Fibrin-specific imaging agents that contain at least two imaging reporters are described, as well as methods of making and using the contrast agents.

    摘要翻译： 描述了含有至少两个成像记录物的纤维蛋白特异性成像剂，以及制造和使用造影剂的方法。