Abstract:
Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R1 is aryl or heteroaryl; R2 is halogen, cycloalkyl, heterocyclyl, aryl, or heteroaryl; R5 is as defined herein; Z is O, S, S(O), S(O)2, or NR5a; X is S, O, N, NR3, or CR3; Y is NCR4 or N4; R3, R4, and R5 are as defined herein; R8 is aryl or heteroaryl; R6 and R7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
Abstract translation:提供了作为葡糖激酶活化剂的化合物,因此可用于治疗糖尿病和相关疾病,并具有以下结构:其中表示一个或两个双键; R 1是芳基或杂芳基; R 2是卤素,环烷基,杂环基,芳基或杂芳基; R 5如本文所定义; Z是O,S,S(O),S(O)2或NR 5a; X是S,O,N,NR 3或CR 3; Y是NCR 4或NR 4; R 3,R 4和R 5如本文所定义; R 8是芳基或杂芳基; R 6和R 7独立地是H,卤素或烷基; m为0或1; 和n为0至3,或其药学上可接受的盐。 还提供了使用上述化合物治疗糖尿病和相关疾病的方法。
Abstract:
Various apparatus and methods are provided for lubricating hard memory disks. A mandrel is provided in one embodiment with three rows of teeth and provides a stable, three-point engagement with the inside edge of the disks at the center aperture. When removing disks from a cassette, the mandrel preferably places a uniform space between the disks. In a second embodiment, the mandrel may be used to lubricate single-sided hard memory disks. The single-sided hard memory disk may be positioned on the mandrel in pairs in a gap merge orientation, or equally spaced apart.
Abstract:
Compounds are provided which have the structure of Formula (I): wherein R is hydrogen or C1-C4 alkyl; and each of R1 and R2 is independently hydrogen, C1-C4 alkyl, halo or C1-C4 alkoxy, and salts thereof, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.
Abstract:
Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.
Abstract:
Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x1 where x1 is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is —(CH2)x2—O—(CH2)x3— where x2 is 0 to 5 and x3 is 0 to 5, provided that at least one of x2 and x3 is other than 0; B is a bond or is (CH2)x4 where x4 is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N; O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C, and specifically excluding the structure(s) as shown below: where X2═N, X3═C, X4═O or S, Z=O or a bond R1 is H or alkyl; R2 is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; R2a, R2b and R2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R3 and Y are as defined herein, which compounds are useful in treating diabetes and obesity.
Abstract:
A stator for a ceiling fan includes a disc with two different depth slots alternately formed on the outer peripheral edge. A primary winding and a secondary winding are respectively wound in the longer slots and the shorter slots. An axle is disposed through the center of the disc and a circuit board including one or more resistors is disposed on a surface of the disc. Two or more contacts are provided for connection to a switch for changing the power supplied to the windings through the contacts in order to change the rotational speed of the ceiling fan. A cavity is formed on the circuit board for receiving the resistors.
Abstract:
Software application protection methods and systems for protecting and verifying licensing of an original application. The system reads the original application executable, and generates a shelled application comprising the original application and a shell containing the license information. The shelled application implements license APIs, and establishes secure communications within the shelled application between the original application and the shell. Licensing for the original application can be verified by the shelled application alone.
Abstract:
Compounds are provided which have the structure of Formula (I): wherein R1 is halogen; and X is hydrogen or halogen, and salts thereof, which compounds are useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic, and anti-obesity agents.
Abstract:
Various apparatus and methods are provided for lubricating hard memory disks. A mandrel is provided in one embodiment with three rows of teeth and provides a stable, three-point engagement with the inside edge of the disks at the center aperture. When removing disks from a cassette, the mandrel preferably places a uniform space between the disks. In a second embodiment, the mandrel may be used to lubricate single-sided hard memory disks. The single-sided hard memory disk may be positioned on the mandrel in pairs in a gap merge orientation, or equally spaced apart.
Abstract:
A power supply for powering an electrical load, the electrical load generating load characteristic data that determines a power supply characteristic to be provided to the electrical load from the power supply, the power supply comprising a voltage regulator for generating an output voltage to be provided as the input voltage for powering the electrical load, the voltage regulator being responsive to a reference signal for setting a characteristic of the power supply, and a control circuit for generating the reference signal for the regulator, the control circuit being responsive to the load characteristic data from the electrical load and to a selection input for selecting the type of electrical load from a plurality of electrical load types, whereby the selection input determines the type of electrical load to enable the load characteristic data to be evaluated by the control circuit to generate the reference signal for the regulator.