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    Biphenyl derivatives, production thereof and uses as medicines
    6.
    发明授权
    Biphenyl derivatives, production thereof and uses as medicines 有权
    联苯衍生物，其生产和用途作为药物

    公开(公告)号：US06617325B1

    公开(公告)日：2003-09-09

    申请号：US10031585

    申请日：2002-05-15

    申请人： Thorsten Lehmann-Lintz ,  Armin Heckel ,  Leo Thomas ,  Michael Mark

    发明人： Thorsten Lehmann-Lintz ,  Armin Heckel ,  Leo Thomas ,  Michael Mark

    IPC分类号： A01N4366

    CPC分类号： C07D211/58

    摘要： The present invention relates to biphenyl derivatives of general formula wherein Ra to Rg and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.

    摘要翻译： 本发明涉及通用化学式R a至R g的联苯基衍生物，n如权利要求1中所定义，它们是微粒体甘油三酯转移蛋白（MTP）的有价值的抑制剂的异构体和盐，特别是其生理上可接受的盐，药物 含有这些化合物及其用途以及其制备方法。

    Substituted piperazine derivatives, the preparation thereof and their use as medicaments
    8.
    发明授权
    Substituted piperazine derivatives, the preparation thereof and their use as medicaments 有权
    取代的哌嗪衍生物，其制备及其作为药物的用途

    公开(公告)号：US06821967B2

    公开(公告)日：2004-11-23

    申请号：US10168486

    申请日：2002-10-09

    申请人： Thorsten Lehmann-Lintz ,  Armin Heckel ,  Leo Thomas ,  Michael Mark

    发明人： Thorsten Lehmann-Lintz ,  Armin Heckel ,  Leo Thomas ,  Michael Mark

    IPC分类号： A61K31496

    CPC分类号： C07D295/145 ,  C07C2603/18

    摘要： The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc, Rf, Rg, X, m and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.

    摘要翻译： 本发明涉及通式为R a，R b，R c，R f，R g，X，m和n的取代哌嗪衍生物，其权利要求1中定义为其异构体和盐，特别是其生理上可接受的盐，它们是有用的抑制剂 微粒体甘油三酯转移蛋白（MTP），含有这些化合物的药物及其用途以及其制备方法。