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公开(公告)号：US07132262B2
公开(公告)日：2006-11-07
申请号：US10630880
申请日：2003-07-30
申请人： Peter Franz Ertl , Gerald Wayne Gough , Christopher Jeffrey Alan Ring , Vanita Parmar , Sarah Marina Walcott
发明人： Peter Franz Ertl , Gerald Wayne Gough , Christopher Jeffrey Alan Ring , Vanita Parmar , Sarah Marina Walcott
IPC分类号： C12P21/06
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C07K2319/00 , C12N15/67 , C12N2710/14143 , C12N2710/20022 , C12N2710/24143
摘要： The present invention relates to methods and compositions useful in the treatment and prevention of human papilloma virus infections and the symptoms and diseases associated therewith. More particularly, the invention relates to polynucleotide sequences which encode human papilloma virus (HPV) amino acid amino acid sequences, wherein the codon usage pattern of the polynucleotide sequences resemble those of highly expressed mammalian genes.
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2.发明申请COMBINATION OF A TNF-ALPHA ANTAGONIST AND A VEGF ANTAGONIST FOR USE IN THE TREATMENT OR PREVENTION OF DISEASES OF THE EYE 审中-公开TNF-ALPHA拮抗剂与VEGF拮抗剂的组合用于治疗或预防眼部疾病公开(公告)号：US20120076787A1
公开(公告)日：2012-03-29
申请号：US13322213
申请日：2010-05-26
IPC分类号： A61K39/395 , A61P27/02 , C07K16/46
CPC分类号： C07K16/241 , A61K39/3955 , A61K2039/507 , C07K16/22 , C07K2317/21 , C07K2317/56 , C07K2317/569 , C07K2319/00 , A61K2300/00
摘要： The invention relates to combinations of TNFα antagonists with VEGF antagonists for use in treating diseases of the eye, and provides antigen-binding proteins which bind to TNFα or a TNFα receptor and/or VEGF or a VEGF receptor.
摘要翻译： 本发明涉及TNFα拮抗剂与用于治疗眼睛疾病的VEGF拮抗剂的组合，并提供与TNFα或TNFα受体和/或VEGF或VEGF受体结合的抗原结合蛋白。
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公开(公告)号：US20120058116A1
公开(公告)日：2012-03-08
申请号：US13265887
申请日：2010-04-22
IPC分类号： A61K39/395 , A61P1/00 , A61P3/00 , C07K19/00 , A61P3/04
CPC分类号： C07K16/2863 , A61K2039/505 , A61K2039/507 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30 , C07K2319/32
摘要： The invention relates to combinations of FGFR1c antagonists with agonist peptides and provide dual targeting proteins which bind to FEFR1c comprising an antigen binding protein which is capable of binding to FGFR1c and which is linked to one or more agonist peptides, methods of making such constructs and uses thereof, particularly in treating obesity.
摘要翻译： 本发明涉及FGFR1c拮抗剂与激动剂肽的组合，并提供与FEFR1c结合的双重靶向蛋白，其包含能够结合FGFR1c并与一种或多种激动剂肽连接的抗原结合蛋白，制备此类构建体和用途的方法 ，特别是治疗肥胖症。
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公开(公告)号：US20110014182A1
公开(公告)日：2011-01-20
申请号：US12746837
申请日：2008-12-09
申请人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Gerald Wayne Gough , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Gerald Wayne Gough , Volker Germaschewski , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , A61P25/28 , A61K38/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with said antigen binding proteins; pharmaceutical compositions comprising said antigen binding proteins; and methods of manufacture.
摘要翻译： 结合β-淀粉样蛋白肽，特别是人和淀粉样蛋白肽的抗原结合蛋白; 治疗疾病或疾病的方法，其特征在于升高的 - 淀粉样蛋白水平或淀粉样蛋白沉积物，特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，包括 年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成，具有所述抗原结合蛋白; 包含所述抗原结合蛋白的药物组合物; 和制造方法。
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公开(公告)号：US08921523B2
公开(公告)日：2014-12-30
申请号：US12330541
申请日：2008-12-09
申请人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Gerald Wayne Gough , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
发明人： Philippe Marc Louis Alard , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Gerald Wayne Gough , Alan Peter Lewis , Peter Ernest Soden , Pamela Joan Thomas , Trevor Anthony Kenneth Wattam
IPC分类号： C07K16/46 , C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/92
摘要： Antigen binding proteins that bind β-amyloid peptide, in particular human β-amyloid peptide; methods of treating diseases or disorders characterized by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease and diseases or disorders affecting the eye or optic nerve characterized by elevated β-amyloid levels or β-amyloid deposits, including age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with the antigen binding proteins; pharmaceutical compositions comprising the antigen binding proteins; and methods of manufacture.
摘要翻译： 结合β-淀粉样蛋白肽，特别是人和淀粉样蛋白肽的抗原结合蛋白; 治疗疾病或疾病的方法，其特征在于升高的 - 淀粉样蛋白水平或淀粉样蛋白沉积物，特别是阿尔茨海默病和影响眼睛或视神经的疾病或病症，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，包括 年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成，与抗原结合蛋白; 包含抗原结合蛋白的药物组合物; 和制造方法。
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公开(公告)号：US20110064819A1
公开(公告)日：2011-03-17
申请号：US12991543
申请日：2009-05-05
IPC分类号： A61K9/14 , A61K39/395 , A61P35/00 , A61P25/28 , B82Y5/00
CPC分类号： A61K9/5138 , A61K9/0019 , A61K9/0051 , A61K9/0085 , A61K9/1647 , A61K9/5153 , A61K9/5192 , A61K2039/505
摘要： The present invention provides methods of encapsulating biologically active agents such as proteins in particulate carriers such as nanoparticles using Hip agents. Also provided are compositions comprising particulate carriers obtainable by such methods and uses of such compositions in treatment.
摘要翻译： 本发明提供了使用Hip剂将生物活性剂如蛋白质包封在颗粒载体如纳米颗粒中的方法。 还提供了包含可通过这些方法和这些组合物在处理中的用途获得的颗粒载体的组合物。
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公开(公告)号：US20110064821A1
公开(公告)日：2011-03-17
申请号：US12991556
申请日：2009-05-05
IPC分类号： A61K9/14 , A61K38/16 , A61K39/395 , A61P27/02 , B82Y5/00
CPC分类号： A61K9/5138 , A61K9/0051 , A61K9/1647 , A61K9/5153 , A61K9/5192 , A61K2039/505 , Y02A50/394
摘要： The present invention provides methods of encapsulating biologically active agents such as proteins in particulate carriers such as nanoparticles. Also provided are methods of delivery of proteins across the blood brain barrier in nanoparticles, and uses of such compositions in treatment.
摘要翻译： 本发明提供了将生物活性剂如蛋白质包封在颗粒载体如纳米颗粒中的方法。 还提供了在纳米颗粒中通过血脑屏障传递蛋白质的方法，以及这些组合物在治疗中的用途。
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公开(公告)号：US20090092623A1
公开(公告)日：2009-04-09
申请号：US10586380
申请日：2005-01-13
CPC分类号： C12N15/85 , A61K48/00 , A61K2039/53 , C07K14/005 , C12N2710/16122
摘要： The present invention provides a novel polynucleotide vectors and their use in the production of biological material in host cells, and also in medical therapy or polynucleotide vaccination. The novel vectors of the present invention comprise a promoter normally associated with the US3 gene of Human Cytomegalovirus (HCMV).
摘要翻译： 本发明提供了一种新的多核苷酸载体及其在宿主细胞中生物生物材料中的应用，以及在药物治疗或多核苷酸疫苗接种中的用途。 本发明的新载体包含通常与人巨细胞病毒（HCMV）的US3基因相关的启动子。
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