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    NANOTUBE-REINFORCED BALLOONS FOR DELIVERING THERAPEUTIC AGENTS WITHIN OR BEYOND THE WALL OF BLOOD VESSELS, AND METHODS OF MAKING AND USING SAME
    2.
    发明申请
    NANOTUBE-REINFORCED BALLOONS FOR DELIVERING THERAPEUTIC AGENTS WITHIN OR BEYOND THE WALL OF BLOOD VESSELS, AND METHODS OF MAKING AND USING SAME 审中-公开
    用于在血液瓶壁之间或之外递送治疗剂的纳米级增强型气泡，以及制造和使用它们的方法

    公开(公告)号：US20120209251A1

    公开(公告)日：2012-08-16

    申请号：US13455973

    申请日：2012-04-25

    申请人： Mark C. Bates

    发明人： Mark C. Bates

    IPC分类号： A61M25/10 ,  B82Y5/00

    CPC分类号： A61L29/126 ,  A61K38/00 ,  A61L29/16 ,  A61L2300/602 ,  A61L2300/624 ,  A61L2400/12 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1084 ,  A61M2025/1086

    摘要： A dilatation catheter for delivering a therapeutic agent within a body lumen having a wall with a thickness is provided having a balloon having a flexible wall including a polymer with dispersed nanotubes and pores configured to close below a predefined pressure and to open at or above a predefined pressure. In some embodiments, an actuator is provided to controllably inflate the balloon with a fluid at a pressure sufficient to bring the flexible wall of the balloon into contact with at least a portion of the wall of the body lumen but below the predefined pressure, and to controllably increase the pressure of the fluid within the inflated balloon to at least the predefined pressure at a rate and with a force sufficient to deliver the therapeutic agent from the pores and through at least a portion of the thickness of the wall of the body lumen.

    摘要翻译： 提供了一种用于在具有厚度的壁的体腔内递送治疗剂的扩张导管，其具有球囊，所述球囊具有柔性壁，弹性壁包括具有分散的纳米管的聚合物和构造成接近低于预定压力的孔，并且在预定义 压力。 在一些实施例中，致动器被提供以用足以使气囊的柔性壁与体腔的至少一部分壁接触但低于预定压力的压力的流体可控制地膨胀气囊，并且 可膨胀气囊内的流体的压力以足以从治疗剂输送治疗剂和通过体腔壁厚度的至少一部分的速度和速度将至少预定的压力增加至至少预定的压力。

    Nanotube-reinforced balloons for delivering therapeutic agents within or beyond the wall of blood vessels, and methods of making and using same
    3.
    发明授权
    Nanotube-reinforced balloons for delivering therapeutic agents within or beyond the wall of blood vessels, and methods of making and using same 有权
    用于在血管壁内或之外递送治疗剂的纳米管增强气囊，以及制造和使用它们的方法

    公开(公告)号：US08187221B2

    公开(公告)日：2012-05-29

    申请号：US12172168

    申请日：2008-07-11

    申请人： Mark C. Bates

    发明人： Mark C. Bates

    IPC分类号： A61M31/00

    CPC分类号： A61L29/126 ,  A61K38/00 ,  A61L29/16 ,  A61L2300/602 ,  A61L2300/624 ,  A61L2400/12 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1084 ,  A61M2025/1086

    摘要： A dilatation catheter for delivering a therapeutic agent within a body lumen having a wall with a thickness is provided having a balloon having a flexible wall including a polymer with dispersed nanotubes and pores configured to close below a predefined pressure and to open at or above a predefined pressure. In some embodiments, an actuator is provided to controllably inflate the balloon with a fluid at a pressure sufficient to bring the flexible wall of the balloon into contact with at least a portion of the wall of the body lumen but below the predefined pressure, and to controllably increase the pressure of the fluid within the inflated balloon to at least the predefined pressure at a rate and with a force sufficient to deliver the therapeutic agent from the pores and through at least a portion of the thickness of the wall of the body lumen.

    摘要翻译： 提供了一种用于在具有厚度的壁的体腔内递送治疗剂的扩张导管，其具有球囊，所述球囊具有柔性壁，弹性壁包括具有分散的纳米管的聚合物和构造成接近低于预定压力的孔，并且在预定义 压力。 在一些实施例中，致动器被提供以用足以使气囊的柔性壁与体腔的至少一部分壁接触但低于预定压力的压力的流体可控制地膨胀气囊，并且 可膨胀气囊内的流体的压力以足以从治疗剂输送治疗剂和通过体腔壁厚度的至少一部分的速度和速度将至少预定的压力增加至至少预定的压力。

    Apparatus and methods for treating tissue using passive injection systems
    5.
    发明授权
    Apparatus and methods for treating tissue using passive injection systems 有权
    使用被动注射系统处理组织的装置和方法

    公开(公告)号：US07862551B2

    公开(公告)日：2011-01-04

    申请号：US12041561

    申请日：2008-03-03

    申请人： Mark C. Bates

    发明人： Mark C. Bates

    IPC分类号： A61M31/00

    CPC分类号： A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00398 ,  A61B2017/00871 ,  A61B2017/3411 ,  A61B2017/3484 ,  A61B2018/00392 ,  A61M5/3287

    摘要： Methods and apparatus are provided for treating damaged tissue using apparatus that atraumatically delivers a bioactive agent within the tissue, wherein the apparatus provides a column of stem cells may be advanced simultaneously with a needle during needle insertion, and then held stationary or injected at low pressure while retracting the needle. Alternatively, the needle may employ electromotive forces, or to change a dimension of the needle, to expel the bioactive agent into the needle track.

    摘要翻译： 提供了使用在组织内无创递送生物活性剂的设备来治疗受损组织的方法和装置，其中所述装置提供的干细胞柱可在针插入期间与针同时进行，然后保持静止或以低压注射 同时缩回针。 或者，针可以采用电动势，或者改变针的尺寸，以将生物活性剂排出到针迹中。

    Apparatus for the delivery of drugs or gene therapy into a patient's vasculature and methods of use
    6.
    发明授权
    Apparatus for the delivery of drugs or gene therapy into a patient's vasculature and methods of use 失效
    用于将药物或基因治疗递送到患者的脉管系统中的装置和使用方法

    公开(公告)号：US07648495B2

    公开(公告)日：2010-01-19

    申请号：US10822037

    申请日：2004-04-08

    申请人： Mark C. Bates

    发明人： Mark C. Bates

    IPC分类号： A61K9/22

    CPC分类号： A61M31/002 ,  A61B17/12109 ,  A61B17/12172 ,  A61B17/12177 ,  A61B17/12181 ,  A61B17/1219 ,  A61B2017/00889 ,  A61B2017/1205 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/45 ,  A61M25/04

    摘要： Methods and apparatus are provided for delivering drugs or gene therapy within a patient's vessel. In a preferred embodiment, the apparatus comprises a material eluting a bioactive substance held in place within the patient's vessel by an anchor. The anchor and eluting material are sized and/or collapsible from a delivery configuration, in which the anchor and material may be delivered into the patient's vasculature within a delivery sheath, to a deployed configuration, wherein the anchor engages an interior wall of the patient's vessel. The eluting material may elute recombinant genes, drugs, or any other bioactive substance.

    摘要翻译： 提供了用于在患者血管内递送药物或基因治疗的方法和装置。 在优选的实施方案中，该装置包括通过锚固物洗脱在患者血管内保持就位的生物活性物质的材料。 锚固和洗脱材料的尺寸和/或可从输送构型定尺寸，其中锚固件和材料可以在输送护套内输送到患者的脉管系统中到展开构型，其中锚固件接合患者血管的内壁 。 洗脱物可以洗脱重组基因，药物或任何其它生物活性物质。

    Nanotube-Reinforced Balloons For Delivering Therapeutic Agents Within Or Beyond The Wall of Blood Vessels, And Methods Of Making And Using Same
    7.
    发明申请
    Nanotube-Reinforced Balloons For Delivering Therapeutic Agents Within Or Beyond The Wall of Blood Vessels, And Methods Of Making And Using Same 有权
    纳米管加强气球用于在血管壁内或超越血管内提供治疗剂，以及制作和使用方法

    公开(公告)号：US20100010470A1

    公开(公告)日：2010-01-14

    申请号：US12172168

    申请日：2008-07-11

    申请人： Mark C. Bates

    发明人： Mark C. Bates

    IPC分类号： A61M25/10 ,  A61K38/43 ,  A61K39/395 ,  A61K38/16

    CPC分类号： A61L29/126 ,  A61K38/00 ,  A61L29/16 ,  A61L2300/602 ,  A61L2300/624 ,  A61L2400/12 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1084 ,  A61M2025/1086

    摘要： A dilatation catheter for delivering a therapeutic agent within a body lumen having a wall with a thickness is provided having a balloon having a flexible wall including a polymer with dispersed nanotubes and pores configured to close below a predefined pressure and to open at or above a predefined pressure. In some embodiments, an actuator is provided to controllably inflate the balloon with a fluid at a pressure sufficient to bring the flexible wall of the balloon into contact with at least a portion of the wall of the body lumen but below the predefined pressure, and to controllably increase the pressure of the fluid within the inflated balloon to at least the predefined pressure at a rate and with a force sufficient to deliver the therapeutic agent from the pores and through at least a portion of the thickness of the wall of the body lumen.

    摘要翻译： 提供了一种用于在具有厚度的壁的体腔内递送治疗剂的扩张导管，其具有球囊，所述球囊具有柔性壁，弹性壁包括具有分散的纳米管的聚合物和构造成接近低于预定压力的孔，并且在预定义 压力。 在一些实施例中，致动器被提供以用足以使气囊的柔性壁与体腔的至少一部分壁接触但低于预定压力的压力的流体可控制地膨胀气囊，并且 可膨胀气囊内的流体的压力以足以从治疗剂输送治疗剂和通过体腔壁厚度的至少一部分的速度和速度将至少预定的压力增加至至少预定的压力。

    Systems and methods for atraumatic implantation of bio-active agents
    8.
    发明授权
    Systems and methods for atraumatic implantation of bio-active agents 有权
    用于无创植入生物活性剂的系统和方法

    公开(公告)号：US07632262B2

    公开(公告)日：2009-12-15

    申请号：US10894810

    申请日：2004-07-19

    申请人： Mark C. Bates

    发明人： Mark C. Bates

    IPC分类号： A61M31/00

    CPC分类号： A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00398 ,  A61B2017/00871 ,  A61B2017/3411 ,  A61B2017/3484 ,  A61B2018/00392 ,  A61M5/3287

    摘要： Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter and a needle disposed within the catheter and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle may be configured to create a tissue space surrounding a distal or lateral surface of the needle, into which the bioactive agent to be infused.

    摘要翻译： 提供了方法和装置，用于在形成针迹之后，通过避免以高速度撞击靶组织或通过使用毛细管作用来吸引生物活性剂，将生物活性剂递送到形成在靶组织块中的针迹中 拔针时出针。 该装置包括导管和设置在导管内的针，并且被配置成选择性地延伸到组织块中到预定深度，同时在沿着针轨缩回针的同时分配药剂。 或者或另外，针可以被配置为产生围绕针的远侧或侧表面的组织空间，待注入的生物活性剂。