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公开(公告)号：US08877900B2
公开(公告)日：2014-11-04
申请号：US13503729
申请日：2010-10-29
申请人： Peter Peizhi Luo , Kevin Caili Wangr , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon , Sujata Sharma , Jon Condra , Jun Lu , Gopalakrishnan Parthasarathy , Stephen Soisson , Noel Byrne
发明人： Peter Peizhi Luo , Kevin Caili Wangr , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon , Sujata Sharma , Jon Condra , Jun Lu , Gopalakrishnan Parthasarathy , Stephen Soisson , Noel Byrne
IPC分类号： C07K16/40 , C07K16/00 , A61K39/395
CPC分类号： C07K16/40 , C07K2299/00 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译： 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US20120213794A1
公开(公告)日：2012-08-23
申请号：US13503729
申请日：2010-10-29
申请人： Peter Peizhi Luo , Kevin Caili Wangr , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon , Sujata Sharma , Jon Condra , Jun Lu , Gopalakrishnan Parthasarathy , Stephen Soisson , Noel Byrne
发明人： Peter Peizhi Luo , Kevin Caili Wangr , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon , Sujata Sharma , Jon Condra , Jun Lu , Gopalakrishnan Parthasarathy , Stephen Soisson , Noel Byrne
IPC分类号： A61K39/395 , C12N15/13 , C12P21/02 , A61P3/06 , C12N5/10 , C12N1/19 , C12N1/21 , C07K16/40 , C12N15/63
CPC分类号： C07K16/40 , C07K2299/00 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译： 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US20120231005A1
公开(公告)日：2012-09-13
申请号：US13503726
申请日：2010-10-29
申请人： Peter Peizhi Luo , Kevin Caili Wang , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon
发明人： Peter Peizhi Luo , Kevin Caili Wang , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon
IPC分类号： C07K16/40 , C12N9/99 , C12N1/21 , C12N15/13 , C12N5/10 , C12P21/02 , A61K39/395 , C12N15/63 , C12N1/19
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译： 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US08802827B2
公开(公告)日：2014-08-12
申请号：US13503726
申请日：2010-10-29
申请人： Peter Peizhi Luo , Kevin Caili Wang , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon
发明人： Peter Peizhi Luo , Kevin Caili Wang , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon
IPC分类号： C07K16/40 , C07K16/00 , A61K39/395
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译： 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US20090136523A1
公开(公告)日：2009-05-28
申请号：US12263919
申请日：2008-11-03
申请人： Teikichi Aoyagi , Peter Peizhi Luo , Pingyu Zhong , Mark Hsieh , Yan Li , Kevin Caili Wang , Chikao Morimoto
发明人： Teikichi Aoyagi , Peter Peizhi Luo , Pingyu Zhong , Mark Hsieh , Yan Li , Kevin Caili Wang , Chikao Morimoto
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06
CPC分类号： C07K16/2896 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , G01N33/574 , G01N2333/70596 , G01N2500/00 , Y02A50/473
摘要： The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
摘要翻译： 本发明提供新的抗CD26抗体和其它相关多肽，以及编码抗体和多肽的新型多核苷酸。 本发明还提供了制备抗体和多肽的方法。 进一步提供包含抗体或多肽的组合物和细胞。 还提供了使用抗体和/或多肽的方法，例如抑制细胞增殖和治疗与CD26相关的病症。
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公开(公告)号：US08030469B2
公开(公告)日：2011-10-04
申请号：US12263919
申请日：2008-11-03
申请人： Teikichi Aoyagi , Peter Peizhi Luo , Pingyu Zhong , Mark Hsieh , Yan Li , Kevin Caili Wang , Chikao Morimoto
发明人： Teikichi Aoyagi , Peter Peizhi Luo , Pingyu Zhong , Mark Hsieh , Yan Li , Kevin Caili Wang , Chikao Morimoto
IPC分类号： C07H21/02 , C07H21/04 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2896 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , G01N33/574 , G01N2333/70596 , G01N2500/00 , Y02A50/473
摘要： The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
摘要翻译： 本发明提供新的抗CD26抗体和其它相关多肽，以及编码抗体和多肽的新型多核苷酸。 本发明还提供了制备抗体和多肽的方法。 进一步提供包含抗体或多肽的组合物和细胞。 还提供了使用抗体和/或多肽的方法，例如抑制细胞增殖和治疗与CD26相关的病症。
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公开(公告)号：US07462698B2
公开(公告)日：2008-12-09
申请号：US11492498
申请日：2006-07-24
申请人： Teikichi Aoyagi , Peter Peizhi Luo , Pingyu Zhong , Mark Hsieh , Yan Li , Kevin Caili Wang , Chikao Morimoto
发明人： Teikichi Aoyagi , Peter Peizhi Luo , Pingyu Zhong , Mark Hsieh , Yan Li , Kevin Caili Wang , Chikao Morimoto
IPC分类号： C12P21/08 , C07K16/00 , A61K35/395 , A61K39/00
CPC分类号： C07K16/2896 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , G01N33/574 , G01N2333/70596 , G01N2500/00 , Y02A50/473
摘要： The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
摘要翻译： 本发明提供新的抗CD26抗体和其它相关多肽，以及编码抗体和多肽的新型多核苷酸。 本发明还提供了制备抗体和多肽的方法。 进一步提供包含抗体或多肽的组合物和细胞。 还提供了使用抗体和/或多肽的方法，例如抑制细胞增殖和治疗与CD26相关的病症。
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公开(公告)号：US20090082221A1
公开(公告)日：2009-03-26
申请号：US12226933
申请日：2007-05-03
申请人： Kevin Caili Wang , Pingyu Zhong , Peter Peizhi Luo
发明人： Kevin Caili Wang , Pingyu Zhong , Peter Peizhi Luo
CPC分类号： C12N15/1037 , C12N15/74 , C12N15/79
摘要： The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for multi-species and cross-species display of polypeptides on the outer surface of prokaryotic genetic packages and/or eukaryotic host cells. The multi-species and cross-species display systems can be practiced using the vector sets of the invention without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of phage, bacterial host cells, yeast cells, and mammalian cells.
摘要翻译： 本发明提供了可以各种组合使用的表达载体和辅助显示载体，作为在原核遗传包和/或真核宿主细胞的外表面上的多物种和多物种展示多肽的载体集。 可以使用本发明的向量集来实现多种和跨物种显示系统，而不必改变或重新设计显示向量。 本发明的显示系统特别可用于在噬菌体，细菌宿主细胞，酵母细胞和哺乳动物细胞的表面上显示遗传多样的多肽或多肽文库。
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公开(公告)号：US08637435B2
公开(公告)日：2014-01-28
申请号：US12291889
申请日：2008-11-14
申请人： Kevin Caili Wang , Peter Peizhi Luo , Pingyu Zhong , Jian Wang
发明人： Kevin Caili Wang , Peter Peizhi Luo , Pingyu Zhong , Jian Wang
CPC分类号： C12N15/1037 , C40B40/02
摘要： The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.
摘要翻译： 本发明提供了可用于各种组合的表达载体和辅助显示载体，作为用于在真核宿主细胞的外表面上显示多肽的载体组。 本发明的表达载体可以单独用于可溶性表达，而不必改变或重新构建显示载体。 本发明的显示系统特别可用于在酵母细胞和哺乳动物细胞的表面上显示遗传多样的多肽或多肽文库。
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公开(公告)号：US20120329679A1
公开(公告)日：2012-12-27
申请号：US13428680
申请日：2012-03-23
申请人： Kevin Caili Wang , Peter Peizhi Luo , Pingyu Zhong , Jian Wang
发明人： Kevin Caili Wang , Peter Peizhi Luo , Pingyu Zhong , Jian Wang
CPC分类号： C12N15/1037 , C40B40/02
摘要： The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.
摘要翻译： 本发明提供了可用于各种组合的表达载体和辅助显示载体，作为用于在真核宿主细胞的外表面上显示多肽的载体组。 本发明的表达载体可以单独用于可溶性表达，而不必改变或重新构建显示载体。 本发明的显示系统特别可用于在酵母细胞和哺乳动物细胞的表面上显示遗传多样的多肽或多肽文库。
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