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公开(公告)号：US20100120700A1
公开(公告)日：2010-05-13
申请号：US12606905
申请日：2009-10-27
申请人： Peter S. Lu , Christoph Peter Bagowski , Johannes Schweizer , Chamorro Somoza Diaz-Sarmiento , Jonathan David Garman , Michael P. Belmares
发明人： Peter S. Lu , Christoph Peter Bagowski , Johannes Schweizer , Chamorro Somoza Diaz-Sarmiento , Jonathan David Garman , Michael P. Belmares
CPC分类号： C07K14/005 , A61K38/00 , C07K14/47 , C07K14/705 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02
摘要： The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid sequence of a particular PDZ domain from the cellular protein MAGI-1. The invention provides methods to treat diseases associated with expression of pathogen proteins by modulating their interactions with MAGI-1, and a number of isolated peptides useful in such methods. Also provided are kits for performing the subject methods.
摘要翻译： 本发明提供了用于治疗病原体感染，特别是人乳头瘤病毒感染的方法和组合物。 具体地，本发明提供了一种筛选方法，其涉及确定候选试剂对来自HPV的致癌菌株的E6蛋白与含有来自细胞蛋白MAGI-1的特定PDZ结构域的氨基酸序列的多肽的结合的影响 。 本发明提供了通过调节与MAGI-1的相互作用来治疗与病原体蛋白表达相关的疾病的方法，以及在这些方法中有用的许多分离的肽。 还提供了用于执行主题方法的套件。
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公开(公告)号：US07399467B2
公开(公告)日：2008-07-15
申请号：US11021949
申请日：2004-12-23
申请人： Peter S. Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter S. Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
IPC分类号： A61K39/395
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
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公开(公告)号：US20120164629A1
公开(公告)日：2012-06-28
申请号：US13364954
申请日：2012-02-02
申请人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
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公开(公告)号：US20100209904A1
公开(公告)日：2010-08-19
申请号：US12660613
申请日：2010-03-01
申请人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
IPC分类号： C12Q1/70
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
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公开(公告)号：US20090047660A1
公开(公告)日：2009-02-19
申请号：US12156013
申请日：2008-05-28
申请人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
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公开(公告)号：US07312041B2
公开(公告)日：2007-12-25
申请号：US10630590
申请日：2003-07-29
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
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公开(公告)号：US20120052484A1
公开(公告)日：2012-03-01
申请号：US13212991
申请日：2011-08-18
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US08048676B2
公开(公告)日：2011-11-01
申请号：US11650455
申请日：2007-01-05
IPC分类号： G01N33/53
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US07972774B2
公开(公告)日：2011-07-05
申请号：US11881724
申请日：2007-07-27
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US20080124702A1
公开(公告)日：2008-05-29
申请号：US11881724
申请日：2007-07-27
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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