CODON MODIFIED POLYNUCLEOTIDE SEQUENCES FOR ENHANCED EXPRESSION IN A HOST SYSTEM
    8.
    发明申请
    CODON MODIFIED POLYNUCLEOTIDE SEQUENCES FOR ENHANCED EXPRESSION IN A HOST SYSTEM 审中-公开
    用于在主机系统中增强表达的CODON修饰的多核苷酸序列

    公开(公告)号:US20130017572A1

    公开(公告)日:2013-01-17

    申请号:US12919684

    申请日:2010-04-30

    IPC分类号: C12N15/34 C12P21/00

    CPC分类号: C12P21/02

    摘要: Synthetic DNA molecules encoding various HPV proteins are provided. The codons of the synthetic molecules are designed so as to use the codons that preferentially increase expression of the polypeptide in the host cell, which in preferred embodiments is a human cell. The codons are modified in order to minimize, decrease or eliminate cellular destruction of the polypeptide construct.

    摘要翻译: 提供编码各种HPV蛋白质的合成DNA分子。 设计合成分子的密码子以便使用优先增加宿主细胞中多肽表达的密码子,其在优选的实施方案中是人细胞。 修饰密码子以最小化,减少或消除多肽构建体的细胞破坏。