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![Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders](/abs-image/US/2015/11/24/US09193726B2/abs.jpg.150x150.jpg)
1.发明授权Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders 有权取代的吡啶并[1,2-a]吡嗪用于治疗神经变性和神经障碍公开(公告)号：US09193726B2
公开(公告)日：2015-11-24
申请号：US14543020
申请日：2014-11-17
Applicant: Pfizer Inc.
Inventor： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William am Ende , Michael Eric Green , Nandini Chaturbhai Patel , Cory Michael Stiff , Tuan Phong Tran , Gregory Wayne Kauffman , Antonia Friederike Stepan , Patrick Robert Verhoest
IPC: C07D241/36 , C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Abstract translation: 公开了化合物的化合物和药学上可接受的盐，其中化合物具有说明书中定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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![Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders](/abs-image/US/2014/12/23/US08916564B2/abs.jpg.150x150.jpg)
2.发明授权Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders 有权取代的吡啶并[1,2-a]吡嗪用于治疗神经变性和神经障碍公开(公告)号：US08916564B2
公开(公告)日：2014-12-23
申请号：US14031163
申请日：2013-09-19
Applicant: Pfizer Inc.
Inventor： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William am Ende , Michael Eric Green , Nandini Chaturbhai Patel , Cory Michael Stiff , Tuan Phong Tran , Gregory Wayne Kauffman , Antonia Friederike Stepan , Patrick Robert Verhoest
IPC: A61K31/4985 , C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Abstract translation: 公开了化合物的化合物和药学上可接受的盐，其中化合物具有说明书中定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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3.发明申请公开(公告)号：US20140323502A1
公开(公告)日：2014-10-30
申请号：US14179694
申请日：2014-02-13
Applicant: PFIZER INC.
Inventor： Anton Franz Joseph Fliri , Randall James Gallaschun , Christopher John O'Donnell , Jacob Bradley Schwarz , Barbara Eileen Segelstein
IPC: C07D409/12 , C07D407/12 , C07D307/22 , C07C307/02 , C07D405/12 , C07D333/38
CPC classification number: C07C307/02 , C07C311/07 , C07C2601/08 , C07C2601/14 , C07D207/08 , C07D213/65 , C07D295/096 , C07D307/22 , C07D307/42 , C07D333/38 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D409/14
Abstract: The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.
Abstract translation: 本发明涉及一类化合物，包括具有式I结构的化合物的药学上可接受的盐：如说明书中所定义的。 本发明还涉及包含和使用式I化合物的组合物。
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公开(公告)号：US20140088111A1
公开(公告)日：2014-03-27
申请号：US14031163
申请日：2013-09-19
Applicant: Pfizer Inc.
Inventor： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William am Ende , Michael Eric Green , Nandini Chaturbhai Patel , Cory Michael Stiff , Tuan Phong Tran , Gregory Wayne Kauffman , Antonia Friederike Stepan , Patrick Robert Verhoest
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Abstract translation: 公开了化合物的化合物和药学上可接受的盐，其中化合物具有说明书中定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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![Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders](/abs-image/US/2017/09/05/US09751877B2/abs.jpg.150x150.jpg)
5.发明授权公开(公告)号：US09751877B2
公开(公告)日：2017-09-05
申请号：US14877118
申请日：2015-10-07
Applicant: Pfizer Inc.
Inventor： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William am Ende , Michael Eric Green , Nandini Chaturbhai Patel , Cory Michael Stiff , Tuan Phong Tran , Gregory Wayne Kauffman , Antonia Friederike Stepan , Patrick Robert Verhoest
IPC: A61K31/4985 , C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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Patent Agency Ranking
公开(公告)号：US09504669B2
公开(公告)日：2016-11-29
申请号：US14818455
申请日：2015-08-05
Applicant: PFIZER INC.
Inventor： Chakrapani Subramanyam , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K38/00 , A61K31/351 , C07D309/10 , C07D405/12 , C07D493/20 , A61K45/06 , A61K47/48 , C07D309/14 , C07D405/14 , C07D493/10 , A61K31/397 , A61K31/453 , A61K31/496 , A61K31/501
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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![Novel Pyrido[1,2-a]Pryazines And Their Use in the Treatment of Neurodegenerative and Neurological Disorders](/abs-image/US/2016/01/28/US20160024088A1/abs.jpg.150x150.jpg)
7.发明申请Novel Pyrido[1,2-a]Pryazines And Their Use in the Treatment of Neurodegenerative and Neurological Disorders 审中-公开新型吡啶并[1,2-a] Pryazine及其用于治疗神经退行性和神经性疾病公开(公告)号：US20160024088A1
公开(公告)日：2016-01-28
申请号：US14877118
申请日：2015-10-07
Applicant: Pfizer Inc.
Inventor： Martin Youngjin Pettersson , Douglas Scott Johnson , Chakrapani Subramanyam , Christopher John O'Donnell , Christopher William am Ende , Michael Eric Green , Nandini Chaturbhai Patel , Cory Michael Stiff , Tuan Phong Tran , Gregory Wayne Kauffman , Antonia Friederike Stepan , Patrick Robert Verhoest
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Abstract translation: 公开了化合物的化合物和药学上可接受的盐，其中化合物具有说明书中定义的式I的结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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公开(公告)号：US08828401B2
公开(公告)日：2014-09-09
申请号：US13670612
申请日：2012-11-07
Applicant: Pfizer Inc.
Inventor： Matthew David Doroski , Andreas Maderna , Christopher John O'Donnell , Chakrapani Subramanyam , Beth Vetelino , Russell George Dushin , Pavel Strop , Edmund Idris Graziani
CPC classification number: C07K7/06 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6889 , C07K5/0205 , C07K5/0808 , C07K7/02 , C07K16/00 , C07K2319/30
Abstract: The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
Abstract translation: 本发明涉及细胞毒性五肽，其抗体药物偶联物及其用于治疗癌症的方法。
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公开(公告)号：US11712480B2
公开(公告)日：2023-08-01
申请号：US16321695
申请日：2017-07-31
Applicant: PFIZER INC.
Inventor： Russell George Dushin , Daniel P. Uccello , Jeremy Starr , Ye Che , Mark Flanagan , Jeffrey M. Casavant , Christopher John O'Donnell , Gary Frederick Filzen , Jennifer Young , Joseph A. Abramite , Lawrence N. Tumey , Ludivine Moine , Adam Matthew Gilbert , Lee R. Roberts
CPC classification number: A61K47/6855 , A61K47/50 , A61K47/545 , A61K47/6867 , C07K4/00 , C07K5/0205 , C07K5/06052 , C07K7/02
Abstract: The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula:
(wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drug conjugates, and the resulting antibody drug conjugates made with components having heteroaryl sulfone-based conjugation handles.-
公开(公告)号：US09764040B2
公开(公告)日：2017-09-19
申请号：US15280563
申请日：2016-09-29
Applicant: PFIZER INC.
Inventor： Chakrapani Subramanyam , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K38/00 , A61K47/48 , C07D309/10 , C07D405/12 , C07D493/20 , A61K45/06 , C07D309/14 , C07D405/14 , C07D493/10 , A61K31/351 , A61K31/397 , A61K31/453 , A61K31/496 , A61K31/501 , A61K31/35 , A61K31/4025
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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