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公开(公告)号：US20130028917A1
公开(公告)日：2013-01-31
申请号：US13641198
申请日：2011-04-15
申请人： Philip Wilson Howard , Luke Masterson , Arnaud Tiberghien , John A. Flygare , Janet L. Gunzner , Paul Polakis , Andrew Polson , Helga E. Raab , Susan D. Spencer
发明人： Philip Wilson Howard , Luke Masterson , Arnaud Tiberghien , John A. Flygare , Janet L. Gunzner , Paul Polakis , Andrew Polson , Helga E. Raab , Susan D. Spencer
IPC分类号： A61K39/395 , A61P35/00 , C07D519/00 , C07K16/00 , C07K16/30
CPC分类号： C07D487/04 , A61K47/6849 , A61K47/6855 , A61K47/6869 , C07D519/00
摘要： Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.
摘要翻译： 公开了用于制备作为通过N10位置连接的PBD分子的缀合物的缀合物和化合物，以及缀合物用于治疗包括癌症在内的增殖性疾病的用途。
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公开(公告)号：US20110256157A1
公开(公告)日：2011-10-20
申请号：US13087575
申请日：2011-04-15
申请人： Philip Wilson Howard , Luke Masterson , Arnaud Tiberghien , John A. Flygare , Janet L. Gunzner , Paul Polakis , Andrew Polson , Helga E. Raab , Susan D. Spencer
发明人： Philip Wilson Howard , Luke Masterson , Arnaud Tiberghien , John A. Flygare , Janet L. Gunzner , Paul Polakis , Andrew Polson , Helga E. Raab , Susan D. Spencer
IPC分类号： A61K39/395 , B65D85/84 , C07K5/062 , C07K17/02 , C07D487/04
CPC分类号： C07D487/04 , A61K47/6849 , A61K47/6855 , A61K47/6869 , C07D519/00
摘要： Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.
摘要翻译： 公开了用于制备作为通过N10位置连接的PBD分子的缀合物的缀合物和化合物，以及缀合物用于治疗包括癌症在内的增殖性疾病的用途。
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3.发明授权Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds 有权蒽环类衍生物缀合物，其制备方法及其作为抗肿瘤化合物的用途公开(公告)号：US08389697B2
公开(公告)日：2013-03-05
申请号：US13360212
申请日：2012-01-27
申请人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
发明人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
IPC分类号： C07H15/24
CPC分类号： C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
摘要： The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
摘要翻译： 本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。
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4.发明申请ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS 有权蒽醌衍生物偶联物，其制备方法及其作为抗微生物化合物的用途公开(公告)号：US20120130059A1
公开(公告)日：2012-05-24
申请号：US13360212
申请日：2012-01-27
申请人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
发明人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
IPC分类号： C07H15/26 , C07H15/252
CPC分类号： C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
摘要： The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
摘要翻译： 本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。
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5.发明申请ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS 有权蒽醌衍生物偶联物，其制备方法及其作为抗微生物化合物的用途公开(公告)号：US20100034837A1
公开(公告)日：2010-02-11
申请号：US12502433
申请日：2009-07-14
申请人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
发明人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina
IPC分类号： A61K31/704 , C07H15/24 , C07K16/46 , C07K14/00 , A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
摘要： The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
摘要翻译： 本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。
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6.发明授权Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds 有权蒽环类衍生物缀合物，其制备方法及其作为抗肿瘤化合物的用途公开(公告)号：US08900589B2
公开(公告)日：2014-12-02
申请号：US12502433
申请日：2009-07-14
申请人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina , Robert L. Cohen
发明人： Italo Beria , Michele Caruso , John A. Flygare , Vittoria Lupi , Rita Perego , Paul Polakis , Andrew Polson , Matteo Salsa , Susan D. Spencer , Barbara Valsasina , Robert L. Cohen
CPC分类号： C07K16/2863 , A61K47/64 , A61K47/6809 , C07K2317/76
摘要： The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin; methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors.
摘要翻译： 本发明涉及治疗有用的蒽环类与载体的缀合物，例如天然或合成来源的多克隆和单克隆抗体，蛋白质或肽; 其制备方法，含有它们的药物组合物及其在治疗某些哺乳动物肿瘤中的用途。
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公开(公告)号：US07994135B2
公开(公告)日：2011-08-09
申请号：US11833954
申请日：2007-08-03
申请人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
发明人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
CPC分类号： C07K16/32 , A61K38/00 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K7/02 , C07K2317/24 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y02A50/491 , Y02A50/492 , Y10T428/13
摘要： Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
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公开(公告)号：US20090081660A1
公开(公告)日：2009-03-26
申请号：US12079586
申请日：2008-03-26
申请人： Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth J. Hillan , Hartmut Koeppen , Heidi S. Phillips , Paul Polakis , Susan D. Spencer , Victoria Smith , P. Mickey Williams , Thomas D. Wu , Zemin Zhang
发明人： Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth J. Hillan , Hartmut Koeppen , Heidi S. Phillips , Paul Polakis , Susan D. Spencer , Victoria Smith , P. Mickey Williams , Thomas D. Wu , Zemin Zhang
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/40 , C07K2317/73 , G01N33/57407
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20090075279A1
公开(公告)日：2009-03-19
申请号：US12156180
申请日：2008-05-29
申请人： Gretchen Frantz , Kenneth J. Hillan , Heidi Phillips , Paul Polakis , Susan D. Spencer , P. Mickey Williams , Thomas D. Wu , Zemin Wang
发明人： Gretchen Frantz , Kenneth J. Hillan , Heidi Phillips , Paul Polakis , Susan D. Spencer , P. Mickey Williams , Thomas D. Wu , Zemin Wang
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： C07K14/4748 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/30 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20090017473A1
公开(公告)日：2009-01-15
申请号：US12156218
申请日：2008-05-29
申请人： Gretchen Frantz , Kenneth J. Hillan , Heidi Phillips , Paul Polakis , Susan D. Spencer , P. Mickey Williams , Thomas D. Wu , Zemin Zhang
发明人： Gretchen Frantz , Kenneth J. Hillan , Heidi Phillips , Paul Polakis , Susan D. Spencer , P. Mickey Williams , Thomas D. Wu , Zemin Zhang
IPC分类号： G01N33/574
CPC分类号： C07K14/4748 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/30 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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