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    Medical apparatus employing flexible light structures and methods for manufacturing same
    1.
    发明申请
    Medical apparatus employing flexible light structures and methods for manufacturing same 审中-公开
    采用柔性灯结构的医疗器械及其制造方法

    公开(公告)号：US20070002582A1

    公开(公告)日：2007-01-04

    申请号：US11323319

    申请日：2005-12-30

    申请人： Phillip Burwell ,  James Chen ,  Zihong Guo ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jennifer Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    发明人： Phillip Burwell ,  James Chen ,  Zihong Guo ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jennifer Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    IPC分类号： A61B1/06

    CPC分类号： A61N5/062 ,  A61N2005/0652

    摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

    摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

    LIGHT GENERATING DEVICE FOR INTRAVASCULAR USE
    2.
    发明申请
    LIGHT GENERATING DEVICE FOR INTRAVASCULAR USE 审中-公开
    光生成装置用于静脉内使用

    公开(公告)号：US20080033519A1

    公开(公告)日：2008-02-07

    申请号：US11834572

    申请日：2007-08-06

    申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    IPC分类号： A61N1/05 ,  A61M29/02 ,  F21S2/00

    CPC分类号： A61N5/062 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0652

    摘要： Light sources are incorporated into a guidewire for enabling the ability to render light therapy be added to catheters that do not have that capability. In one exemplary embodiment, a solid guidewire includes a conductive core, and light sources are added to compartments formed in a distal end of the guidewire. In another exemplary embodiment, a light source array is included in a distal end of a hollow guidewire. A plurality of openings are formed into the walls of the hollow guidewire surrounding the array, enabling light to pass through the openings. Conductors extend from the array though the hollow center of the guidewire, to a proximal end of the hollow guidewire. The hollow guidewire can be coated with a conductive material, so that the coating on the guidewire serves as a conductor.

    摘要翻译： 光源被结合到导丝中，以使能够将光疗法添加到不具有该能力的导管的能力。 在一个示例性实施例中，实心导线包括导电芯，并且将光源添加到形成在导丝的远端中的隔室。 在另一示例性实施例中，光源阵列包括在中空导丝的远端中。 多个开口形成在围绕阵列的中空导丝的壁中，使得光能够穿过开口。 导体通过导丝的中空中心从阵列延伸到中空导丝的近端。 中空导丝可以用导电材料涂覆，使得导丝上的涂层用作导体。

    Light generating device to intravascular use
    3.
    发明申请
    Light generating device to intravascular use 有权
    发光装置用于血管内使用

    公开(公告)号：US20050228260A1

    公开(公告)日：2005-10-13

    申请号：US10799357

    申请日：2004-03-12

    申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    IPC分类号： A61B18/22 ,  A61M20060101 ,  A61N1/00 ,  A61N5/00 ,  A61N5/06 ,  A61N5/10

    CPC分类号： A61N5/0601 ,  A61B2018/2261 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652 ,  A61N2005/1003

    摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

    摘要翻译： 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

    LIGHT GENERATING DEVICE FOR INTRAVASCULAR USE
    4.
    发明申请
    LIGHT GENERATING DEVICE FOR INTRAVASCULAR USE 有权
    光生成装置用于静脉内使用

    公开(公告)号：US20080027517A1

    公开(公告)日：2008-01-31

    申请号：US11773555

    申请日：2007-07-05

    申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

    IPC分类号： A61N5/06

    CPC分类号： A61N5/0601 ,  A61B2018/2261 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652 ,  A61N2005/1003

    摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

    摘要翻译： 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

    Device for distal protection and treatment of blood vessels
    5.
    发明申请
    Device for distal protection and treatment of blood vessels 审中-公开
    远端保护和治疗血管的装置

    公开(公告)号：US20050131510A1

    公开(公告)日：2005-06-16

    申请号：US10888572

    申请日：2004-07-09

    申请人： James Chen ,  David Shine ,  Gary Lichttenegger ,  Zihong Guo ,  Phillip Burwell ,  Steven Daly

    发明人： James Chen ,  David Shine ,  Gary Lichttenegger ,  Zihong Guo ,  Phillip Burwell ,  Steven Daly

    IPC分类号： A61B17/22 ,  A61M20060101 ,  A61N1/05 ,  A61N5/06

    CPC分类号： A61N5/062 ,  A61B2017/22051 ,  A61N5/0601 ,  A61N2005/0652

    摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source and distal protection device comprising a shape memory polymer. Yet another device is a catheter having two balloons and a sleeve extending therebetween. Within the sleeve, the catheter includes a light source and an expanding member.

    摘要翻译： 用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。 第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。 如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。 第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括光源和包括形状记忆聚合物的远端保护装置。 另一个装置是具有两个气囊的导管和在它们之间延伸的套管。 在套管内，导管包括光源和扩张构件。

    Light generating device that self centers within a lumen to render photodynamic therapy
    6.
    发明申请
    Light generating device that self centers within a lumen to render photodynamic therapy 审中-公开
    自发中心在光腔内产生光动力治疗的发光装置

    公开(公告)号：US20050128742A1

    公开(公告)日：2005-06-16

    申请号：US10888567

    申请日：2004-07-08

    申请人： James Chen ,  Zihong Guo ,  Gary Lichttenegger ,  David Shine ,  Phillip Burwell

    发明人： James Chen ,  Zihong Guo ,  Gary Lichttenegger ,  David Shine ,  Phillip Burwell

    IPC分类号： A61B20060101 ,  A61N5/06 ,  A61N5/067 ,  A61N5/10 ,  F21S2/00

    CPC分类号： A61N5/0601 ,  A61M2025/1047 ,  A61N5/062 ,  A61N2005/0652 ,  A61N2005/1003

    摘要： A light generating device for illuminating tissue adjacent to a body lumen while a distal end of the device is centered in the lumen, to render photodynamic therapy. The device can either occlude or displace bodily fluid, both without the use of a balloon. In one embodiment, a flushing lumen has a port adjacent to an array of light sources, to displace bodily fluid that might otherwise absorb light. Another embodiment employs a centering member that moves between a first position and a second position. The centering member centers the device in the lumen and preferably is formed of a shape memory material. In yet another embodiment, the device includes an outer sheath and an inner member that are independently positionable, enabling the centering member to be selectively positionable. The centering member can be non porous, such that the centering member also occludes fluid flow.

    摘要翻译： 一种发光装置，用于在装置的远端位于管腔中心的同时照射邻近体腔的组织，以进行光动力学治疗。 该装置可以封闭或移动体液，而不使用气球。 在一个实施例中，冲洗内腔具有与光源阵列相邻的端口，以移位否则可能吸收光的体液。 另一实施例采用在第一位置和第二位置之间移动的定心构件。 定心构件将装置居中在内腔中，并且优选地由形状记忆材料形成。 在另一个实施例中，该装置包括可独立定位的外护套和内部构件，使得定心构件能够选择性地定位。 定心构件可以是非多孔的，使得定心构件也阻塞流体流动。

    Light delivery apparatus
    7.
    发明申请
    Light delivery apparatus 审中-公开
    发光装置

    公开(公告)号：US20070142880A1

    公开(公告)日：2007-06-21

    申请号：US11594570

    申请日：2006-11-07

    申请人： William Barnard ,  Phillip Burwell ,  James Chen ,  Julene Christophersen ,  William Gembala ,  David Shine

    发明人： William Barnard ,  Phillip Burwell ,  James Chen ,  Julene Christophersen ,  William Gembala ,  David Shine

    IPC分类号： A61N5/06

    CPC分类号： A61N5/0603 ,  A61N5/0601 ,  A61N5/062

    摘要： A light delivery apparatus to provide light treatment to a patient includes a catheter assembly having a light source that transmit light towards a target site within a patient. A balloon surrounds the light source and has a plurality of tissue engaging elements movable between first positions and second positions. In one embodiment, each element extends radially inward in the first position and radially outward in the second position. An insertion tool is used to deliver the light delivery apparatus. During use, the light delivery apparatus is rotationally locked with the insertion tool for improved steering, navigation, and aiming of emitted light.

    摘要翻译： 为患者提供光治疗的光输送装置包括导管组件，所述导管组件具有将光发射到患者内的目标部位的光源。 气囊围绕光源并且具有可在第一位置和第二位置之间移动的多个组织接合元件。 在一个实施例中，每个元件在第一位置处径向向内延伸并且在第二位置中径向向外延伸。 插入工具用于输送光输送装置。 在使用期间，光输送装置与插入工具旋转地锁定，以改善对发射光的转向，导航和瞄准。