-
公开(公告)号:US5698391A
公开(公告)日:1997-12-16
申请号:US357396
申请日:1994-12-16
申请人: Phillip Dan Cook , David J. Ecker , Jacqueline Wyatt , Thomas W. Bruice , Kevin Anderson , Ronnie Hanecak , Timothy Vickers , Peter Davis , Susan M. Freier , Yogesh S. Sanghvi , Vickie Brown-Driver
发明人: Phillip Dan Cook , David J. Ecker , Jacqueline Wyatt , Thomas W. Bruice , Kevin Anderson , Ronnie Hanecak , Timothy Vickers , Peter Davis , Susan M. Freier , Yogesh S. Sanghvi , Vickie Brown-Driver
CPC分类号: C12Q1/6811 , G01N33/5308
摘要: Methods useful for the determination of oligomers which have specific activity for a target molecule from a pool of primarily randomly assembled oligomers are provided. The disclosed methods involve repeated syntheses of increasingly simplified sets of oligomers coupled with selection procedures for determining oligomers having the highest activity. Freedom from the use of enzymes allows the application of these methods to any molecules which can be oligomerized in a controlled fashion.
摘要翻译: 提供了用于测定从主要随机组装的低聚物库中的靶分子具有比活性的低聚物的方法。 所公开的方法涉及重复合成越来越简单的低聚体组合,以及用于确定具有最高活性的寡聚体的选择程序。 不使用酶允许将这些方法应用于可以以受控方式低聚的任何分子。
-
2.
公开(公告)号:US20070015723A1
公开(公告)日:2007-01-18
申请号:US11436901
申请日:2006-05-17
申请人: Ronnie Hanecak , Kevin Anderson , C. Bennett , Ming-Yi Chiang , Vickie Brown-Driver , David Ecker , Timothy Vickers , Jacqueline Wyatt
发明人: Ronnie Hanecak , Kevin Anderson , C. Bennett , Ming-Yi Chiang , Vickie Brown-Driver , David Ecker , Timothy Vickers , Jacqueline Wyatt
IPC分类号: A61K48/00
CPC分类号: A61K31/70 , A61K38/00 , C07H21/00 , C12N15/1133 , C12N15/1137 , C12N15/115 , C12N15/117 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12Q1/701 , C12Y207/07049 , C12Y301/01004 , C12N2310/3521
摘要: Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus or phospholipase A2 or to modulate the telomere length of a chromosome are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.
摘要翻译: 修饰的寡核苷酸具有保守的GAT4序列和足够数量的侧翼核苷酸以显着抑制病毒或磷脂酶A 2的活性或调节染色体的端粒长度 被提供。 还提供了G 4四重寡核苷酸结构。 还提供了与升高的磷脂酶A 2 2水平相关的病毒相关疾病和疾病的预防,诊断和治疗方法。 还提供了调节染色体端粒长度的方法; 相信端粒长度的调节在细胞的衰老过程中和恶性细胞生长的控制中起作用。
-
3.
公开(公告)号:US20050261228A1
公开(公告)日:2005-11-24
申请号:US11089191
申请日:2005-03-23
申请人: C. Bennett , Brenda Baker , Susan Freier , Susan Gregory , Ronnie Hanecak , Kevin Anderson , Ming-Yi Chiang , Vickie Brown-Driver , David Ecker , Timothy Vickers , Jacqueline Wyatt , Eric Marcusson , Nicholas Dean , Sanjay Bhanot , Elizabeth Ackermann , Lex Cowsert
发明人: C. Bennett , Brenda Baker , Susan Freier , Susan Gregory , Ronnie Hanecak , Kevin Anderson , Ming-Yi Chiang , Vickie Brown-Driver , David Ecker , Timothy Vickers , Jacqueline Wyatt , Eric Marcusson , Nicholas Dean , Sanjay Bhanot , Elizabeth Ackermann , Lex Cowsert
IPC分类号: A61K38/00 , A61K48/00 , C07H21/04 , C12N15/113 , C12N15/85
CPC分类号: C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要: Compounds, compositions and methods are provided for modulating the expression of Interleukin 12 p35 subunit. The compositions comprise chemically modified antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin 12 p35 subunit. Methods of using these compounds for modulation of Interleukin 12 p35 subunit expression and for treatment of diseases associated with expression of Interleukin 12 p35 subunit are provided.
摘要翻译: 提供化合物,组合物和方法用于调节白细胞介素12p35亚基的表达。 组合物包含靶向编码白细胞介素12p35亚基的核酸的化学修饰的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节白介素12p35亚基表达和治疗与白细胞介素12p35亚基表达相关的疾病的方法。
-
公开(公告)号:US20070010562A1
公开(公告)日:2007-01-11
申请号:US10486748
申请日:2002-08-13
申请人: Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hebert , John Kiely , Ingo Kober , Manfred Kogl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
发明人: Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hebert , John Kiely , Ingo Kober , Manfred Kogl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
IPC分类号: A61K31/4436 , A61K31/44 , C07D409/04 , C07D213/72
CPC分类号: C07D213/74 , C07B2200/11 , C07D261/08 , C07D277/42
摘要: The present invention relates to compounds according to the general formula (1) which bind to the NR1H4 receptor and act as agonists, antagonists or mixed agonists/antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and the production of medicaments using said compounds.
摘要翻译: 本发明涉及结合NR1H4受体并且作为NR1H4受体的激动剂,拮抗剂或混合激动剂/拮抗剂的根据通式(1)的化合物。 本发明还涉及通过所述化合物结合所述核受体和使用所述化合物生产药物来治疗疾病和/或病症。
-
公开(公告)号:US07098336B2
公开(公告)日:2006-08-29
申请号:US10217141
申请日:2002-08-13
申请人: Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
发明人: Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
IPC分类号: C07D239/42 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号: C07D261/08 , C07B2200/11 , C07D213/74 , C07D239/42 , C07D409/04
摘要: The invention provides compounds according to the general formula (1) which bind to the NR1H4 receptor and act as agonists, antagonists or mixed agonists/antagonists of the NR1H4 receptor. The invention further provides methods of treating diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compounds.
摘要翻译: 本发明提供了结合NR 1 H 4受体并且作为NR 1 H 4受体的激动剂,拮抗剂或混合激动剂/拮抗剂的根据通式(1)的化合物。 本发明还提供了通过化合物与核受体结合并使用该化合物生产药物来治疗疾病和/或病症的方法。
-
公开(公告)号:US07034046B2
公开(公告)日:2006-04-25
申请号:US10185721
申请日:2002-07-01
申请人: Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
发明人: Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
IPC分类号: A61K31/42 , C07D261/08
CPC分类号: C07D261/08 , C07B2200/11 , C07D213/74 , C07D239/42 , C07D409/04
摘要: The present invention relates to compounds according to the general formula (I) which bind to the nuclear receptor, NR1H4, and act as agonists and antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds.
-
公开(公告)号:US06974830B2
公开(公告)日:2005-12-13
申请号:US10185731
申请日:2002-07-01
申请人: Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
发明人: Ulrike Bauer , Zach Cheruvallath , Ulrich Deuschle , Elena Dneprovskaia , Tim Gahman , Kristina Giegrich , Ronnie Hanecak , Normand Hébert , John Kiely , Ingo Kober , Manfred Kögl , Harald Kranz , Claus Kremoser , Matthew Lee , Kerstin Otte , Carlton Sage , Manish Sud
IPC分类号: A61K31/42 , A61K31/506 , A61P3/04 , A61P9/00 , A61P35/00 , C07D213/74 , C07D239/42 , C07D261/08 , C07D277/38 , A61K31/426 , C07D277/20
CPC分类号: C07D261/08 , C07B2200/11 , C07D213/74 , C07D239/42 , C07D409/04
摘要: The present invention relates to compounds according to the general formula (I) which bind to the NR1H4 receptor and act as agonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compounds.
摘要翻译: 本发明涉及结合NR1H4受体并作为NR1H4受体激动剂的通式(I)的化合物。 本发明还涉及通过化合物与核受体的结合和使用该化合物的药物的生产来治疗疾病和/或病症。
-
-
-
-
-
-