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1.发明申请AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR BETA-SECRETASE MODULATION 审中-公开AMINO-5-（6-MEMBERED）异环糊精化合物及其用于BETA-分泌酶调节的用途公开(公告)号：US20090042908A1
公开(公告)日：2009-02-12
申请号：US12248996
申请日：2008-10-10
申请人： Ping Zhou , Michael Sotirios Malamas , Yanfang Li , Albert Jean Robichaud , Dominick Anthony Quagliato
发明人： Ping Zhou , Michael Sotirios Malamas , Yanfang Li , Albert Jean Robichaud , Dominick Anthony Quagliato
IPC分类号： A61K31/497 , A61K31/4439 , A61K31/444 , A61P25/28 , A61P25/00 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译： 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法
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2.发明授权Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation 失效氨基-5-（6元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途公开(公告)号：US07452885B2
公开(公告)日：2008-11-18
申请号：US11478098
申请日：2006-06-29
申请人： Ping Zhou , Michael Sotirios Malamas , Yanfang Li , Albert Jean Robichaud , Dominick Anthony Quagliato
发明人： Ping Zhou , Michael Sotirios Malamas , Yanfang Li , Albert Jean Robichaud , Dominick Anthony Quagliato
IPC分类号： C07D403/04 , A61K31/4439
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。
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![Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of β-secretase](/abs-image/US/2008/09/09/US07423158B2/abs.jpg.150x150.jpg)
3.发明授权Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of β-secretase 失效用于抑制β-分泌酶的氨基-5- [4-（二氟甲氧基）苯基] -5-苯基咪唑啉酮化合物公开(公告)号：US07423158B2
公开(公告)日：2008-09-09
申请号：US11526511
申请日：2006-09-25
申请人： Michael Sotirios Malamas , James Joseph Erdei , William Floyd Fobare , Dominick Anthony Quagliato , Schuyler Adam Antane , Albert Jean Robichaud
发明人： Michael Sotirios Malamas , James Joseph Erdei , William Floyd Fobare , Dominick Anthony Quagliato , Schuyler Adam Antane , Albert Jean Robichaud
IPC分类号： A61K31/4168 , C07D233/44
CPC分类号： C07D233/88 , C07D401/12 , C07D409/12
摘要： The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的2-氨基-5- [4-（二氟甲氧基）苯基] -5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白的方法 沉积物和神经原纤维缠结。
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公开(公告)号：US20100204245A1
公开(公告)日：2010-08-12
申请号：US12763612
申请日：2010-04-20
申请人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, JR. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud
发明人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, JR. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud
IPC分类号： A61K31/497 , C07D401/06 , A61K31/4439 , C07D401/12 , A61K31/444 , A61K31/506 , A61P25/28 , C12N5/071
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D417/14
摘要： The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的氨基 - 吡啶化合物本发明还提供了其用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的方法。
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![Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase](/abs-image/US/2010/05/25/US07723368B2/abs.jpg.150x150.jpg)
5.发明授权Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase 失效用于抑制β-分泌酶的氨基-5- [4-（二氟甲氧基）苯基] -5-苯基咪唑啉酮化合物公开(公告)号：US07723368B2
公开(公告)日：2010-05-25
申请号：US12053086
申请日：2008-03-21
申请人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim , Schuyler Adam Antane
发明人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim , Schuyler Adam Antane
IPC分类号： A61K31/4166 , A61K31/4168 , C07D233/30
CPC分类号： C07D233/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供了用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的化合物和方法。
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![Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone Compounds For The Inhibition Of Beta-secretase](/abs-image/US/2010/07/01/US20100168194A1/abs.jpg.150x150.jpg)
6.发明申请Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone Compounds For The Inhibition Of Beta-secretase 审中-公开氨基-5- [4-（二氟甲氧基）苯基] -5-苯基咪唑酮化合物抑制β-分泌酶公开(公告)号：US20100168194A1
公开(公告)日：2010-07-01
申请号：US12721086
申请日：2010-03-10
申请人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim , Schuyler Adam Antane
发明人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim , Schuyler Adam Antane
IPC分类号： A61K31/4166 , C07D233/30 , A61P25/28
CPC分类号： C07D233/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供了用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的化合物和方法。
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![AMINO-5-[4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE](/abs-image/US/2009/02/19/US20090048320A1/abs.jpg.150x150.jpg)
7.发明申请AMINO-5-[4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE 失效氨基-5- [4-（二氟甲基）苯基] -5-苯基咪唑烷酮化合物用于抑制β-分泌酶公开(公告)号：US20090048320A1
公开(公告)日：2009-02-19
申请号：US12053086
申请日：2008-03-21
申请人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim
发明人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , Koi Michele Morris , William R. Solvibile , Ji-In Kim
IPC分类号： A61K31/4168 , C07D233/46 , C12N9/00 , A61P25/28
CPC分类号： C07D233/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds and methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的化合物和方法。
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公开(公告)号：US07732457B2
公开(公告)日：2010-06-08
申请号：US11344432
申请日：2006-01-31
申请人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, Jr. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud
发明人： Michael Sotirios Malamas , William Floyd Fobare , William Ronald Solvibile, Jr. , Frank Eldridge Lovering , Jeffrey Scott Condon , Albert Jean Robichaud
IPC分类号： A61K31/506 , C07D401/14
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D417/14
摘要： The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的氨基 - 吡啶化合物本发明还提供了其用于抑制和分泌（BACE）和治疗和淀粉样沉积物和神经原纤维缠结的方法。
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![AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS AS BETA-SECRETASE INHIBITORS](/abs-image/US/2009/02/12/US20090042964A1/abs.jpg.150x150.jpg)
9.发明申请AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS AS BETA-SECRETASE INHIBITORS 审中-公开氨基-5- [取代-4-（二氟甲基）苯基] -5-苯基咪唑烷酮化合物作为β-分泌酶抑制剂公开(公告)号：US20090042964A1
公开(公告)日：2009-02-12
申请号：US12052098
申请日：2008-03-20
申请人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , William R. Solvibile , Koi Michele Morris , Schuyler Adam Antane , Ji-In Kim , Robert Emmett McDevitt
发明人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , William R. Solvibile , Koi Michele Morris , Schuyler Adam Antane , Ji-In Kim , Robert Emmett McDevitt
IPC分类号： A61K31/4168 , C07D233/32 , A61P25/00
CPC分类号： C07D233/88
摘要： The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译： 本发明提供式I的2-氨基-5- [取代-4-（二氟甲氧基）苯基] -5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β 淀粉样沉积物和神经原纤维缠结。
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10.发明授权Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands 有权取代的3-磺基吲唑衍生物作为5-羟色胺-6配体公开(公告)号：US07723329B2
公开(公告)日：2010-05-25
申请号：US11504350
申请日：2006-08-14
申请人： Hassan Mahmoud Elokdah , Alexander Alexei Greenfield , Kevin Liu , Robert Emmett McDevitt , Geraldine Ruth McFarlane , Cristina Grosanu , Jennifer Rebecca Lo , Yanfang Li , Albert Jean Robichaud , Ronald Charles Bernotas
发明人： Hassan Mahmoud Elokdah , Alexander Alexei Greenfield , Kevin Liu , Robert Emmett McDevitt , Geraldine Ruth McFarlane , Cristina Grosanu , Jennifer Rebecca Lo , Yanfang Li , Albert Jean Robichaud , Ronald Charles Bernotas
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/416 , C07D413/02 , C07D231/56
CPC分类号： C07D231/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12
摘要： The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译： 本发明提供式I化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。
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