公开(公告)号：US08760652B2

公开(公告)日：2014-06-24

申请号：US13654747

申请日：2012-10-18

Applicant: Postnova Analytics GmbH

Inventor： Dietheim Fröse ,  Roland Welz

IPC: G01N21/00

CPC classification number: G01N21/51 ,  G01N21/53 ,  G01N30/74 ,  G01N2021/4711 ,  G01N2201/064

Abstract: An apparatus for measuring the light scattering properties of a sample in a liquid medium, wherein the liquid medium with the sample is illuminated by a laser beam in a measuring cell transversely to the direction of filling the liquid medium in the measuring cell or transversely to the flow direction of the liquid medium within the measuring cell, comprising a laser, a cylindrical measuring cell, a first inner aperture system, a second outer aperture system and at least two detectors, wherein the detectors are arranged outside of the second outer aperture system so that they collect the light scattered on the sample within set, different angle ranges, wherein the first inner aperture system and the second outer aperture system are formed and arranged circularly and concentrically around the axis of the measuring cell. Use of the apparatus and a method that makes use of the apparatus are also disclosed.

Abstract translation: 一种用于测量液体介质中的样品的光散射性质的装置，其中具有样品的液体介质通过横向于在测量池中填充液体介质的方向的横向于横向于测量单元的测量单元中的激光束照射 测量单元内的液体介质的流动方向，包括激光器，圆柱形测量单元，第一内孔系统，第二外孔系统和至少两个检测器，其中检测器布置在第二外孔系统的外侧，因此 它们收集在集合的不同角度范围内散射在样品上的光，其中第一内孔系统和第二外孔系统被形成并围绕测量池的轴线圆周且同心地布置。 还公开了使用该装置和使用该装置的方法。

公开(公告)号：US10132782B2

公开(公告)日：2018-11-20

申请号：US15042398

申请日：2016-02-12

Applicant: Postnova Analytics GmbH

Inventor： Roland Welz ,  Thorsten Klein

IPC: G01N30/00 ,  B01D11/04 ,  G01N30/74

Abstract: The present invention relates to an apparatus for field-flow fractionation and to a method for separating samples by means of field-flow fractionation using this apparatus. The apparatuses of the invention comprise a separation channel which, in addition to a first outlet for sample-containing solvent, comprises a second outlet for sample-free solvent, wherein the second outlet is arranged in a region of the separation channel from which sample-free solvent may be removed during elution and a flow volume control device is arranged downstream of the second outlet. They are characterized in that the flow volume control device is a mass flow controller.

公开(公告)号：US20130100433A1

公开(公告)日：2013-04-25

申请号：US13654747

申请日：2012-10-18

Applicant: Postnova Analytics GmbH

Inventor： Diethelm Frose ,  Roland Welz

IPC: G01N21/51

CPC classification number: G01N21/51 ,  G01N21/53 ,  G01N30/74 ,  G01N2021/4711 ,  G01N2201/064

Abstract: An apparatus for measuring the light scattering properties of a sample in a liquid medium, wherein the liquid medium with the sample is illuminated by a laser beam in a measuring cell transversely to the direction of filling the liquid medium in the measuring cell or transversely to the flow direction of the liquid medium within the measuring cell, comprising a laser, a cylindrical measuring cell, a first inner aperture system, a second outer aperture system and at least two detectors, wherein the detectors are arranged outside of the second outer aperture system so that they collect the light scattered on the sample within set, different angle ranges, wherein the first inner aperture system and the second outer aperture system are formed and arranged circularly and concentrically around the axis of the measuring cell. Use of the apparatus and a method that makes use of the apparatus are also disclosed.

Abstract translation: 一种用于测量液体介质中的样品的光散射性质的装置，其中具有样品的液体介质通过横向于在测量池中填充液体介质的方向的横向于横向于测量单元的测量单元中的激光束照射 测量单元内的液体介质的流动方向，包括激光器，圆柱形测量单元，第一内孔系统，第二外孔系统和至少两个检测器，其中检测器布置在第二外孔系统的外侧，因此 它们收集在集合的不同角度范围内散射在样品上的光，其中第一内孔系统和第二外孔系统被形成并围绕测量池的轴线圆周且同心地布置。 还公开了使用该装置和使用该装置的方法。

公开(公告)号：US20160238571A1

公开(公告)日：2016-08-18

申请号：US15042398

申请日：2016-02-12

Applicant: Postnova Analytics GmbH

Inventor： Roland Welz ,  Thorsten Klein

IPC: G01N30/00 ,  G01N21/41 ,  G01N15/14 ,  B01D11/04 ,  G01N30/74

CPC classification number: G01N30/0005 ,  B01D11/04 ,  G01N30/74 ,  G01N2030/003 ,  G01N30/32

Abstract: The present invention relates to an apparatus for field-flow fractionation and to a method for separating samples by means of field-flow fractionation using this apparatus. The apparatuses of the invention comprise a separation channel which, in addition to a first outlet for sample-containing solvent, comprises a second outlet for sample-free solvent, wherein the second outlet is arranged in a region of the separation channel from which sample-free solvent may be removed during elution and a flow volume control device is arranged downstream of the second outlet. They are characterized in that the flow volume control device is a mass flow controller.

Abstract translation: 本发明涉及一种用于现场流分级的装置以及使用该装置通过场流分级分离样品的方法。 本发明的装置包括分离通道，除了用于含样品的溶剂的第一出口之外，还包括用于无样品溶剂的第二出口，其中第二出口布置在分离通道的区域中， 在洗脱期间可以除去游离溶剂，并且流量控制装置布置在第二出口的下游。 其特征在于流量控制装置是质量流量控制器。

公开(公告)号：US20140066280A1

公开(公告)日：2014-03-06

申请号：US13821237

申请日：2012-05-21

Applicant: POSTNOVA ANALYTICS GMBH

Inventor： Roland Welz

IPC: B04B9/12 ,  B04B15/06

CPC classification number: B04B15/06 ,  B04B5/0442 ,  B04B9/12 ,  B04B11/02 ,  G01N30/0005 ,  G01N2030/002

Abstract: The current invention relates to an apparatus for performing a centrifugal field-flow fractionation. In particular, in the apparatus according to the invention, radial rotary shaft seals are used for sealing the rotating parts of the shaft for carrying out the centrifugal field-flow fractionation and the stationary parts. Furthermore, a separate line is introduced for reducing the pressure differential across these seals. In such way, the driving force driving sample fluid across the seals is reduced, thereby reducing leakage.

Abstract translation: 本发明涉及一种用于进行离心场流分级的装置。 特别地，在本发明的装置中，使用径向旋转轴密封件来密封轴的旋转部分，用于进行离心场流分离和静止部分。 此外，引入了一条单独的管线，以减少跨越这些密封件的压力差。 以这种方式，通过密封件驱动样品流体的驱动力减小，从而减少泄漏。

公开(公告)号：US09329082B2

公开(公告)日：2016-05-03

申请号：US14294450

申请日：2014-06-03

Applicant: Postnova Analytics GmbH

Inventor： Roland Welz

IPC: G01J1/42 ,  G01J1/08 ,  G01N15/02 ,  G01N21/51 ,  G01N21/47

CPC classification number: G01J1/42 ,  G01J1/08 ,  G01J2001/4295 ,  G01N15/0205 ,  G01N21/51 ,  G01N2021/4707 ,  G01N2021/4711

Abstract: The invention provides a method for measuring light scattered on a sample in a medium, in particular a fluid medium, that comprises the following steps: providing a rotatably arranged measuring cell with a substantially circular cross-section in a plane perpendicular to the axis of rotation for receiving the medium and the sample, rotating the measuring cell, preferably at least once by substantially 360°, about the axis of rotation, in particular by means of a drive, emitting a laser beam by means of a laser onto the sample located within the measuring cell in the plane perpendicular to the axis of rotation at different angles of rotation of the measuring cell, the measuring cell maintaining its position in the direction of the axis of rotation, detecting scattered light signals by means of at least two detectors arranged in a circle and concentrically to the center of rotation of the measuring cell and fixed within set, different angular ranges at different angles of rotation of the measuring cell, and determining a corrected signal value for each detector on the basis of the scattered light signals detected at different angles of rotation of the measuring cell for each detector. Furthermore, the invention provides an apparatus for measuring light scattered on a sample according to the method comprising a laser, a measuring cell and a detector.

Abstract translation: 本发明提供一种用于测量在介质，特别是流体介质中的样品上散射的光的方法，该方法包括以下步骤：在垂直于旋转轴线的平面中提供具有基本圆形横截面的可旋转布置的测量单元 用于接收介质和样品，特别是借助于驱动器，将测量单元，优选至少一次旋转约360°旋转轴线，通过激光将激光束发射到位于 所述测量单元在垂直于所述测量单元的不同旋转角度的旋转轴线的平面中，所述测量单元保持其在所述旋转轴线的方向上的位置，通过布置在所述测量单元中的至少两个检测器来检测散射光信号 圆圈并同心对准测量单元的旋转中心并固定在不同的角度范围内，在不同的旋转角度 基于在每个检测器的测量单元的不同旋转角度检测的散射光信号，确定每个检测器的校正信号值。 此外，本发明提供了一种根据包括激光，测量单元和检测器的方法测量在样品上散射的光的装置。

公开(公告)号：US20140354990A1

公开(公告)日：2014-12-04

申请号：US14294450

申请日：2014-06-03

Applicant: Postnova Analytics GmbH

Inventor： Roland Welz

IPC: G01J1/42 ,  G01J1/08 ,  G01N15/02

CPC classification number: G01J1/42 ,  G01J1/08 ,  G01J2001/4295 ,  G01N15/0205 ,  G01N21/51 ,  G01N2021/4707 ,  G01N2021/4711

Abstract: The invention provides a method for measuring light scattered on a sample in a medium, in particular a fluid medium, that comprises the following steps: providing a rotatably arranged measuring cell with a substantially circular cross-section in a plane perpendicular to the axis of rotation for receiving the medium and the sample, rotating the measuring cell, preferably at least once by substantially 360°, about the axis of rotation, in particular by means of a drive, emitting a laser beam by means of a laser onto the sample located within the measuring cell in the plane perpendicular to the axis of rotation at different angles of rotation of the measuring cell, the measuring cell maintaining its position in the direction of the axis of rotation, detecting scattered light signals by means of at least two detectors arranged in a circle and concentrically to the centre of rotation of the measuring cell and fixed within set, different angular ranges at different angles of rotation of the measuring cell, and determining a corrected signal value for each detector on the basis of the scattered light signals detected at different angles of rotation of the measuring cell for each detector. Furthermore, the invention provides an apparatus for measuring light scattered on a sample according to the method comprising a laser, a measuring cell and a detector.

Abstract translation: 本发明提供一种用于测量在介质，特别是流体介质中的样品上散射的光的方法，该方法包括以下步骤：在垂直于旋转轴线的平面中提供具有基本圆形横截面的可旋转布置的测量单元 用于接收介质和样品，特别是借助于驱动器，将测量单元，优选至少一次旋转约360°旋转轴线，通过激光将激光束发射到位于 所述测量单元在垂直于所述测量单元的不同旋转角度的旋转轴线的平面中，所述测量单元保持其在所述旋转轴线的方向上的位置，通过布置在所述测量单元中的至少两个检测器来检测散射光信号 圆圈并同心对准测量单元的旋转中心并固定在不同的角度范围内，在不同的旋转角度 基于在每个检测器的测量单元的不同旋转角度检测的散射光信号，确定每个检测器的校正信号值。 此外，本发明提供了一种根据包括激光，测量单元和检测器的方法测量在样品上散射的光的装置。