摘要:
A method and system for estimating the volume of blood ejected from the left ventricle of the heart to a succeeding chamber/conduit, or vice-versa, while imaging the intersection of such structures is described. The process utilizes either the M-mode to estimate volume differences in a view of the ventricle over time or Doppler processing techniques to obtain flow profiles across intersections (e.g., valves), or blood vessels, which are then utilized to calculate output. This process can be combined with ECG guidance/triggering to measure/track changes in output from beat to beat, or during the course of an evaluation or therapeutic procedure. This process can be specifically used for the placement of permanent pacemaker electrodes.
摘要:
An imaging system is provided with an ultrasound catheter and a controller coupled to the ultrasound catheter. The catheter includes a localizer sensor configured to generate positional information for the ultrasound catheter, and an imaging ultrasound sensor having a restricted field of view. The controller co-registers images from the imaging ultrasound sensor with positional information from the localizer sensor.
摘要:
A system and method for limiting a temperature induced in a body by an ultrasound imaging catheter are provided. The method includes receiving, at an isolation box, an imaging signal from an imaging catheter, receiving, at an isolation box, a signal indicative of a temperature of tissue adjacent to the imaging catheter, removing power to the imaging catheter at the isolation box if the signal indicates the temperature of tissue adjacent to the imaging catheter exceeds a known value, and sending the imaging signal from the catheter to a processor if the signal indicates the temperature of tissue adjacent to the imaging catheter is less than the limit.
摘要:
A method and system for enhancing Doppler spectrum displays is described. Two or more colors are utilized to represent the power scale in the spectral Doppler display. Doppler signals from stronger reflectors of ultrasound, such as cardiac muscle or vessel walls, can then be assigned a different color than Doppler signals from weaker reflectors, such as blood, allowing for better understanding and interpretation of the Doppler spectra.
摘要:
An intra-cardiac imaging system that includes an ultrasound catheter that can image the left heart from within the right heart. The catheter has a proximal end, a distal end, and a lumen extending therebetween. The distal end includes an acoustic window longitudinally oriented and having a length of at least ten millimeters. A linear ultrasound transducer having an active surface is longitudinally mounted inside the lumen of the catheter at the distal end of the catheter adjacent the acoustic window. The active surface of the ultrasound transducer is directed toward the acoustic window, is approximately the same length as the acoustic window, and is capable of transmitting an ultrasound signal at a frequency of about 1.5 MHz to about 9 MHz.
摘要:
The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding domains for two different binding sites of LRP6 and compositions and methods of use thereof.
摘要:
The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics.
摘要:
The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL4 and as diagnostics.
摘要:
An all-optical cross-connect switching system provides optical switching that may reduce processing requirements by three orders of magnitude over conventional techniques by associating at least one optical detector with an optical beam steering element. In one embodiment, a first beam steering element, having a reflective surface in optical association with a first optical fiber array, and a second beam steering element, having a reflective surface in optical association with a second optical fiber array, are optically arranged to direct an optical beam from a first optical fiber in the first optical fiber array to a second optical fiber in the second optical fiber array. The optical detector provides information about a first position of the optical beam on the second beam steering element. Based on this information, the angle of the first beam steering element may be adjusted to cause the optical beam to change to a second position on the second beam steering element.