公开(公告)号：US6001916A

公开(公告)日：1999-12-14

申请号：US170917

申请日：1998-10-13

申请人： James L. Walker ,  Pravin Kukkala

发明人： James L. Walker ,  Pravin Kukkala

IPC分类号： C08F2/16 ,  C08F255/02 ,  C08F263/04 ,  C08F265/04 ,  C09J151/00

CPC分类号： C08F265/04 ,  C08F255/026 ,  C08F263/04 ,  C09J151/003

摘要： A process for the production of ethylene vinyl acetate based polymer emulsions having solids levels greater than about 65% by weight comprising the steps of:i) providing a polymer seed selected from the group consisting of vinyl acetate, ethylene vinyl acetate, acrylic, vinyl-acrylic and styrene (meth) acrylic having a particle size of 0.15 to 2.5 microns;ii) polymerizing vinyl acetate and ethylene monomers in the presence of 5 to 15% by weight of the final emulsion of said polymer seed;said polymerization of step (ii) being carried out in the presence of a surfactant system comprising polyvinyl alcohol and a nonionic emulsifier.

摘要翻译： 一种制备具有大于约65重量％的固体含量的乙烯 - 乙酸乙烯酯基聚合物乳液的方法，包括以下步骤：i）提供选自乙酸乙烯酯，乙烯 - 乙酸乙烯酯，丙烯酸，乙烯基 - 丙烯酸和苯乙烯（甲基）丙烯酸，其粒径为0.15〜2.5微米; ii）在5至15重量％的所述聚合物种子的最终乳液的存在下聚合乙酸乙烯酯和乙烯单体; 所述步骤（ii）的聚合在包含聚乙烯醇和非离子乳化剂的表面活性剂体系的存在下进行。

公开(公告)号：US5916968A

公开(公告)日：1999-06-29

申请号：US918173

申请日：1997-08-25

申请人： Deepak Hariharan ,  Roman Bradel ,  Rama Chandran ,  Pravin Kukkala

发明人： Deepak Hariharan ,  Roman Bradel ,  Rama Chandran ,  Pravin Kukkala

IPC分类号： A61K9/70 ,  A61L15/58 ,  A61L15/64 ,  C08G18/28 ,  C08G18/60 ,  C08G18/62 ,  C08G18/64 ,  C08G18/72 ,  C09J133/00 ,  C09J151/00 ,  C09J105/00 ,  C09J133/08

CPC分类号： A61K9/7053 ,  C08G18/2805 ,  C08G18/603 ,  C08G18/6204 ,  C08G18/6484 ,  C08G18/728 ,  C08G2170/40 ,  C08G2230/00

摘要： A graft copolymer for use as an adhesive for drug delivery patches or dressings that is resistant to dissolution in the presence of skin penetration enhancers comprises copolymerized acrylic and, optionally, vinyl monomers, to form a backbone polymer, to which are grafted polymeric moieties that do not absorb greater than 3% by weight of a skin-penetration enhancer under thermodynamic equilibrium at 25.degree. C. if independently introduced into an excess of the enhancer. Preferably, the grafted polymers are selected from the classes of polybutylene, polysaccharide, poly(ethyleneoxide/propyleneoxide), and polyamide polymers, and specific grafted polymers will depend on the specific enhancers used in a particular drug delivery system.

摘要翻译： 用作药物递送贴剂或敷料的粘合剂的接枝共聚物，其在皮肤渗透增强剂存在下耐溶解，包括共聚丙烯酸和任选的乙烯基单体以形成主链聚合物，其中接枝的聚合物部分 如果独立地引入过量的增强剂中，则在25℃的热力学平衡下不吸收大于3重量％的皮肤渗透增强剂。 优选地，接枝聚合物选自聚丁烯，多糖，聚（环氧乙烷/环氧丙烷）和聚酰胺聚合物的类型，特定的接枝聚合物将取决于特定药物递送系统中使用的特异性增强剂。

公开(公告)号：US5939505A

公开(公告)日：1999-08-17

申请号：US991355

申请日：1997-12-16

申请人： Pravin Kukkala

发明人： Pravin Kukkala

IPC分类号： C08L23/08 ,  C08F2/00 ,  C08F2/30 ,  C08F2/44 ,  C08F210/02 ,  C08F218/08 ,  C08L31/04 ,  C08L51/00 ,  C09J123/08

CPC分类号： C08F210/02 ,  C08F218/08 ,  C09J123/08

摘要： In a process for the polymerization of aqueous ethylene vinyl acetate emulsions wherein the polymerization is carried out in the presence of a stabilizing system comprising polyvinyl alcohol and a surfactant, the improvement which comprises using a stabilizing system consisting essentially of 2 to 8% polyvinyl alcohol and 0.25 to 4% of at least one surface-active compound comprising the addition products of 50 to 70 moles of ethylene oxide adducted to straight-chained or branch-chained alkanols or alkylphenols containing 6 to 22 carbon atoms in the alkyl group and having an HLB value equal to or greater than 18.0, the amounts being based on total vinyl acetate.

摘要翻译： 在聚乙烯乙酸乙烯酯水溶液的聚合方法中，其中聚合在包含聚乙烯醇和表面活性剂的稳定体系的存在下进行，其改进包括使用基本上由2至8％的聚乙烯醇和 0.25至4％的至少一种表面活性化合物，其包含加成产物的50-70摩尔环氧乙烷加成直链或支链链烷醇或烷基中含有6至22个碳原子的烷基酚，并具有HLB 值等于或大于18.0，该量基于总乙酸乙烯酯。

公开(公告)号：US5858549A

公开(公告)日：1999-01-12

申请号：US783350

申请日：1997-01-07

申请人： Andrew J. Kielbania, Jr. ,  Pravin Kukkala ,  Sharon Lee ,  John C. Leighton

发明人： Andrew J. Kielbania, Jr. ,  Pravin Kukkala ,  Sharon Lee ,  John C. Leighton

IPC分类号： C08K5/21 ,  C08L33/02 ,  C08L67/00 ,  C08L101/02 ,  C09D167/00 ,  B32B27/08 ,  C08F283/00 ,  C08G69/48 ,  C08L75/00

CPC分类号： C08K5/21 ,  C09D167/00 ,  Y10T428/24628 ,  Y10T428/31725 ,  Y10T428/31794

摘要： (Hydroxyalkyl)urea crosslinking agents and compositions which utilize such crosslinking agents are disclosed. The crosslinking agents contain a single urea group, at least two hydroxyl groups, and have at least two carbon atoms disposed between the urea group and each of the hydroxyl groups. The compositions contain a poly-functional molecule which contains at least two functional groups selected from the group consisting of carboxyl, anhydride and amine.

摘要翻译： （羟烷基）脲交联剂和利用这种交联剂的组合物。 交联剂含有单个脲基团，至少两个羟基，并且在尿素基团和每个羟基之间具有至少两个碳原子。 所述组合物含有含有至少两个选自羧基，酸酐和胺的官能团的多官能分子。