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公开(公告)号：US10960397B2
公开(公告)日：2021-03-30
申请号：US16916532
申请日：2020-06-30
发明人： Seth Fraden , Hakim Boukellal , Yanwei Jia , Seila Selimovic , Amy Rowat , Jeremy Agresti , David A. Weitz
摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
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公开(公告)号：US10675626B2
公开(公告)日：2020-06-09
申请号：US16573466
申请日：2019-09-17
发明人： Seth Fraden , Hakim Boukellal , Yanwei Jia , Seila Selimovic , Amy Rowat , Jeremy Agresti , David A. Weitz
摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
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公开(公告)号：US10357772B2
公开(公告)日：2019-07-23
申请号：US16105283
申请日：2018-08-20
发明人： Seth Fraden , Hakim Boukellal , Yanwei Jia , Seila Selimovic , Amy Rowat , Jeremy Agresti , David A. Weitz
摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
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公开(公告)号：US11618024B2
公开(公告)日：2023-04-04
申请号：US17184202
申请日：2021-02-24
发明人： Seth Fraden , Hakim Boukellal , Yanwei Jia , Seila Selimovic , Amy Rowat , Jeremy Agresti , David A. Weitz
摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
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公开(公告)号：US20190255530A1
公开(公告)日：2019-08-22
申请号：US16400401
申请日：2019-05-01
发明人： Seth Fraden , Hakim Boukellal , Yanwei Jia , Seila Selimovic , Amy Rowat , Jeremy Agresti , David A. Weitz
摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
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6.发明授权Manipulation of fluids, fluid components and reactions in microfluidic systems 有权在微流体系统中操纵流体，流体组分和反应公开(公告)号：US09588025B2
公开(公告)日：2017-03-07
申请号：US14737865
申请日：2015-06-12
发明人： Seth Fraden , Hakim Boukellal , Yanwei Jia , Seila Selimovic , Amy Rowat , Jeremy Agresti , David A. Weitz
CPC分类号： B01L3/502784 , B01L3/502746 , B01L2200/0673 , B01L2300/0861 , B01L2300/087 , B01L2300/0877 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , B01L2400/082 , F17D1/12 , G01N1/28 , G01N15/0272 , G01N15/1484 , G01N2015/0092 , Y10T137/0324 , Y10T137/0391 , Y10T137/0396 , Y10T137/2082 , Y10T137/218 , Y10T436/2575
摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
摘要翻译： 提供微流体结构和操作流体，流体组分和反应的方法。 在一个方面，这种结构和方法可以允许产生精确体积的液滴，其可被存储/保持在装置的精确区域。 在另一方面，本文所述的微流体结构和方法被设计用于在组件中容纳和定位组件，使得即使在操作之后也可以操纵组件并随后进行跟踪。 例如，细胞可以以本文所述的微流体结构的排列约束，以便于在其生长期间和/或在它们繁殖之后进行跟踪。
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7.发明申请MANIPULATION OF FLUIDS, FLUID COMPONENTS AND REACTIONS IN MICROFLUIDIC SYSTEMS 有权微流控系统中流体，流体组分和反应的操作公开(公告)号：US20150276562A1
公开(公告)日：2015-10-01
申请号：US14737865
申请日：2015-06-12
发明人： Seth Fraden , Hakim Boukellal , Yanwei Jia , Seila Selimovic , Amy Rowat , Jeremy Agresti , David A. Weitz
IPC分类号： G01N1/28
CPC分类号： B01L3/502784 , B01L3/502746 , B01L2200/0673 , B01L2300/0861 , B01L2300/087 , B01L2300/0877 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , B01L2400/082 , F17D1/12 , G01N1/28 , G01N15/0272 , G01N15/1484 , G01N2015/0092 , Y10T137/0324 , Y10T137/0391 , Y10T137/0396 , Y10T137/2082 , Y10T137/218 , Y10T436/2575
摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
摘要翻译： 提供了用于操纵流体，流体组分和反应的微流体结构和方法。 在一个方面，这种结构和方法可以允许产生精确体积的液滴，其可被存储/保持在装置的精确区域。 在另一方面，本文所述的微流体结构和方法被设计用于在组件中容纳和定位组件，使得即使在操作之后也可以操纵组件并随后进行跟踪。 例如，细胞可以以本文所述的微流体结构的排列约束，以便于在其生长期间和/或在它们繁殖之后进行跟踪。
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8.发明授权Manipulation of fluids, fluid components and reactions in microfluidic systems 有权在微流体系统中操纵流体，流体组分和反应公开(公告)号：US09068699B2
公开(公告)日：2015-06-30
申请号：US14070953
申请日：2013-11-04
发明人： Seth Fraden , Hakim Boukellal , Yanwei Jia , Seila Selimovic , Amy Rowat , Jeremy Agresti , David A. Weitz
CPC分类号： B01L3/502784 , B01L3/502746 , B01L2200/0673 , B01L2300/0861 , B01L2300/087 , B01L2300/0877 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , B01L2400/082 , F17D1/12 , G01N1/28 , G01N15/0272 , G01N15/1484 , G01N2015/0092 , Y10T137/0324 , Y10T137/0391 , Y10T137/0396 , Y10T137/2082 , Y10T137/218 , Y10T436/2575
摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
摘要翻译： 提供了用于操纵流体，流体组分和反应的微流体结构和方法。 在一个方面，这种结构和方法可以允许产生精确体积的液滴，其可被存储/保持在装置的精确区域。 在另一方面，本文所述的微流体结构和方法被设计用于在组件中容纳和定位组件，使得即使在操作之后也可以操纵组件并随后进行跟踪。 例如，细胞可以以本文所述的微流体结构的排列约束，以便于在其生长期间和/或在它们繁殖之后进行跟踪。
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公开(公告)号：US11224876B2
公开(公告)日：2022-01-18
申请号：US16400401
申请日：2019-05-01
发明人： Seth Fraden , Hakim Boukellal , Yanwei Jia , Seila Selimovic , Amy Rowat , Jeremy Agresti , David A. Weitz
摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
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公开(公告)号：US20190039071A1
公开(公告)日：2019-02-07
申请号：US16105283
申请日：2018-08-20
发明人： Seth Fraden , Hakim Boukellal , Yanwei Jia , Seila Selimovic , Amy Rowat , Jeremy Agresti , David A. Weitz
CPC分类号： B01L3/502784 , B01L3/502746 , B01L2200/0673 , B01L2300/0861 , B01L2300/087 , B01L2300/0877 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , B01L2400/082 , F17D1/12 , G01N1/28 , G01N15/0272 , G01N15/1484 , G01N2015/0092 , Y10T137/0324 , Y10T137/0391 , Y10T137/0396 , Y10T137/2082 , Y10T137/218 , Y10T436/2575
摘要： Microfluidic structures and methods for manipulating fluids, fluid components, and reactions are provided. In one aspect, such structures and methods can allow production of droplets of a precise volume, which can be stored/maintained at precise regions of the device. In another aspect, microfluidic structures and methods described herein are designed for containing and positioning components in an arrangement such that the components can be manipulated and then tracked even after manipulation. For example, cells may be constrained in an arrangement in microfluidic structures described herein to facilitate tracking during their growth and/or after they multiply.
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