公开(公告)号：US20190170614A1

公开(公告)日：2019-06-06

申请号：US16266874

申请日：2019-02-04

申请人： Pulse Health LLC

发明人： Martin Krauss ,  Maura Mahon ,  Andrew King ,  Steve Cooper ,  James Ingle ,  Gerald Thomas ,  David Barsic ,  Neal Andrews ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC分类号： G01N1/22 ,  A61B5/08 ,  G01N33/52 ,  G01N21/64 ,  G01N33/497 ,  G01D11/24 ,  G01N33/64

摘要： An analysis cartridge the includes a main body portion and a filter assembly. The main body portion includes an upper portion that defines an upper chamber and a lower portion that defines a fluid chamber. The filter assembly is movable along a filter assembly path between a first position and a second position. The filter assembly has an opening defined therethrough. In the first position, the opening partially defines the upper chamber and in the second position the opening partially defines the fluid chamber.

公开(公告)号：US20190041332A1

公开(公告)日：2019-02-07

申请号：US16050459

申请日：2018-07-31

申请人： Pulse Health LLC

发明人： Gerald Thomas ,  Charles Noll ,  Juven Lara ,  Brian Young ,  Craig Carlsen ,  Bruce Branchaud ,  James Ingle

IPC分类号： G01N21/64

摘要： Methods, systems and reagents are provided for detecting and quantifying carbonyl containing moieties in a variety of sample types.

公开(公告)号：US20170199125A1

公开(公告)日：2017-07-13

申请号：US15351406

申请日：2016-11-14

申请人： Pulse Health LLC

发明人： Steve Cooper ,  Neal Andrews ,  Maura Mahon ,  Rachel Dreilinger ,  David Barsic ,  Weston Myler ,  Martin Krauss ,  Scot Herbst ,  James Ingle ,  Gerald Thomas ,  Rich Myers ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC分类号： G01N21/64 ,  G01N1/22 ,  G01N33/64

CPC分类号： G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

摘要： A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.

公开(公告)号：US20170284905A1

公开(公告)日：2017-10-05

申请号：US15408276

申请日：2017-01-17

申请人： Pulse Health LLC

发明人： Martin Krauss ,  Maura Mahon ,  Andrew King ,  Steve Cooper ,  James Ingle ,  Gerald Thomas ,  David Barsic ,  Neal Andrews ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC分类号： G01N1/22 ,  G01N33/64 ,  G01D11/24 ,  G01N33/52 ,  G01N21/64 ,  G01N33/497

CPC分类号： G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

摘要： An analysis cartridge the includes a main body portion and a filter assembly. The main body portion includes an upper portion that defines an upper chamber and a lower portion that defines a fluid chamber. The filter assembly is movable along a filter assembly path between a first position and a second position. The filter assembly has an opening defined therethrough. In the first position, the opening partially defines the upper chamber and in the second position the opening partially defines the fluid chamber.

公开(公告)号：US09546930B2

公开(公告)日：2017-01-17

申请号：US14754594

申请日：2015-06-29

申请人： Pulse Health LLC

发明人： Martin Krauss ,  Maura Mahon ,  Andrew E. King ,  Steve Cooper ,  James Ingle ,  Gerald Thomas ,  David Barsic ,  Neal Andrews ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC分类号： G01N21/78 ,  G01N21/76 ,  G01N21/64 ,  G01N21/62 ,  G01N1/22 ,  G01N33/497 ,  G01D11/24 ,  G01N33/52

CPC分类号： G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

摘要： An analysis cartridge the includes a main body portion and a filter assembly. The main body portion includes an upper portion that defines an upper chamber and a lower portion that defines a fluid chamber. The filter assembly is movable along a filter assembly path between a first position and a second position. The filter assembly has an opening defined therethrough. In the first position, the opening partially defines the upper chamber and in the second position the opening partially defines the fluid chamber.

摘要翻译： 分析盒包括主体部分和过滤器组件。 主体部分包括限定上室的上部和限定流体室的下部。 过滤器组件可沿着过滤器组件路径在第一位置和第二位置之间移动。 过滤器组件具有通过其限定的开口。 在第一位置，开口部分地限定上室，并且在第二位置，开口部分地限定流体室。

公开(公告)号：US09494495B2

公开(公告)日：2016-11-15

申请号：US14754608

申请日：2015-06-29

申请人： Pulse Health LLC

发明人： Steve Cooper ,  Neal Andrews ,  Maura Mahon ,  Rachel Dreilinger ,  David Barsic ,  Weston Myler ,  Martin Krauss ,  Scot Herbst ,  James Ingle ,  Gerald Thomas ,  Rick Myers ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC分类号： G01N21/64 ,  G01N21/62 ,  G01N33/52 ,  G01N33/48 ,  G01N1/22 ,  G01N33/497 ,  G01D11/24

CPC分类号： G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

摘要： A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.

摘要翻译： 一种呼吸分析系统，其包括在其上端具有分析盒的手柄组件。 手柄包括具有压力开口的主体部分和其中的压力换能器。 分析盒包括主体部分，其具有限定呼吸室的上部，限定流体室的下部和可在呼吸捕获位置和分析位置之间移动的过滤器组件。 过滤器组件具有通过其限定的开口。 在呼吸捕获位置，开口部分地限定呼吸室，并且在分析位置中，开口部分地限定流体室。 该系统还包括具有壳体的分析装置，门，控制电动机的控制器和位于壳体内部的荧光检测组件和旋转组件。 旋转组件包括具有漏斗部分的护罩，用于接纳分析盒。

公开(公告)号：US20150377868A1

公开(公告)日：2015-12-31

申请号：US14754608

申请日：2015-06-29

申请人： Pulse Health LLC

发明人： Steve Cooper ,  Neal Andrews ,  Maura Mahon ,  Rachel Dreilinger ,  David Barsic ,  Weston Myler ,  Martin Krauss ,  Scot Herbst ,  James Ingle ,  Gerald Thomas ,  Rick Myers ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC分类号： G01N33/52

CPC分类号： G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

摘要： A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.

公开(公告)号：US20190257757A1

公开(公告)日：2019-08-22

申请号：US16403309

申请日：2019-05-03

申请人： Pulse Health LLC

发明人： Gerald Thomas ,  Juven Lara ,  Brian Young ,  Charles Noll ,  Craig Carlsen ,  James Ingle

IPC分类号： G01N21/64 ,  A61B5/097 ,  G01N30/74 ,  G01N30/36 ,  G01N30/34 ,  A61B5/08 ,  A61B5/00

摘要： Systems and methods directed to aldehyde detection are disclosed. An aldehyde detection system may capture aldehydes from a patient breath sample. Aldehydes of the breath sample may be used to form a mobile chromatography phase within an analysis device. The analysis device may include various modules configured to perform a high pressure liquid chromatography process that separates aldehydes according to size. A detection assembly may detect a relative value of the separated aldehydes. The analysis device may be configured to determine an aldehyde score or metric based on the detected aldehydes, which may assist in the diagnosis of certain medical conditions.

公开(公告)号：US20150377859A1

公开(公告)日：2015-12-31

申请号：US14754594

申请日：2015-06-29

申请人： Pulse Health LLC

发明人： Martin Krauss ,  Maura Mahon ,  Adrew E. King ,  Steve Cooper ,  James Ingle ,  Gerald Thomas ,  David Barsic ,  Neal Andrews ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC分类号： G01N33/497 ,  G01N21/64

CPC分类号： G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

摘要： An analysis cartridge the includes a main body portion and a filter assembly. The main body portion includes an upper portion that defines an upper chamber and a lower portion that defines a fluid chamber. The filter assembly is movable along a filter assembly path between a first position and a second position. The filter assembly has an opening defined therethrough. In the first position, the opening partially defines the upper chamber and in the second position the opening partially defines the fluid chamber.

摘要翻译： 分析盒包括主体部分和过滤器组件。 主体部分包括限定上室的上部和限定流体室的下部。 过滤器组件可沿着过滤器组件路径在第一位置和第二位置之间移动。 过滤器组件具有通过其限定的开口。 在第一位置，开口部分地限定上室，并且在第二位置，开口部分地限定流体室。

公开(公告)号：US20150377748A1

公开(公告)日：2015-12-31

申请号：US14754534

申请日：2015-06-29

申请人： Pulse Health LLC

发明人： Steve Cooper ,  Neal Andrews ,  Martin Krauss ,  Andrew E. King ,  Maura Mahon ,  Weston Myler ,  James Ingle ,  Gerald Thomas ,  Rachel Dreilinger ,  David Barsic ,  Rick Myers ,  Craig Carlsen ,  Scot Herbst ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC分类号： G01N1/22 ,  G01N21/64 ,  G01D11/24 ,  G01N33/497

CPC分类号： G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

摘要： A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.

摘要翻译： 一种呼吸分析系统，其包括在其上端具有分析盒的手柄组件。 手柄包括具有压力开口的主体部分和其中的压力换能器。 分析盒包括主体部分，其具有限定呼吸室的上部，限定流体室的下部和可在呼吸捕获位置和分析位置之间移动的过滤器组件。 过滤器组件具有通过其限定的开口。 在呼吸捕获位置，开口部分地限定呼吸室，并且在分析位置中，开口部分地限定流体室。 该系统还包括具有壳体的分析装置，门，控制电动机的控制器和位于壳体内部的荧光检测组件和旋转组件。 旋转组件包括具有用于接收分析盒的漏斗部分的护罩。