利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.028 秒)

    Method and System for Multi-Scale Anatomical and Functional Modeling of Coronary Circulation
    3.
    发明申请
    Method and System for Multi-Scale Anatomical and Functional Modeling of Coronary Circulation 审中-公开
    冠状动脉循环多尺度解剖与功能建模方法与系统

    公开(公告)号：US20130132054A1

    公开(公告)日：2013-05-23

    申请号：US13672781

    申请日：2012-11-09

    申请人： Puneet Sharma ,  Lucian Mihai Itu ,  Bogdan Georgescu ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu

    发明人： Puneet Sharma ,  Lucian Mihai Itu ,  Bogdan Georgescu ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu

    IPC分类号： G06F19/12

    CPC分类号： G06F19/12 ,  G06F19/00 ,  G06F19/321 ,  G16H50/30 ,  G16H50/50

    摘要： A method and system for multi-scale anatomical and functional modeling of coronary circulation is disclosed. A patient-specific anatomical model of coronary arteries and the heart is generated from medical image data of a patient. A multi-scale functional model of coronary circulation is generated based on the patient-specific anatomical model. Blood flow is simulated in at least one stenosis region of at least one coronary artery using the multi-scale function model of coronary circulation. Hemodynamic quantities, such as fractional flow reserve (FFR), are computed to determine a functional assessment of the stenosis, and virtual intervention simulations are performed using the multi-scale function model of coronary circulation for decision support and intervention planning.

    摘要翻译： 公开了一种用于冠状循环多尺度解剖和功能建模的方法和系统。 冠状动脉和心脏的患者特异性解剖模型由患者的医学图像数据产生。 基于患者特异性解剖模型产生冠状动脉循环的多尺度功能模型。 使用冠状动脉循环的多尺度功能模型在至少一个冠状动脉的至少一个狭窄区域中模拟血流量。 计算血流动力学量，例如分数流量储备（FFR），以确定狭窄的功能评估，并使用冠状动脉循环的多尺度函数模型进行虚拟干预模拟，以进行决策支持和干预计划。

    Method and system for advanced measurements computation and therapy planning from medical data and images using a multi-physics fluid-solid heart model
    4.
    发明授权
    Method and system for advanced measurements computation and therapy planning from medical data and images using a multi-physics fluid-solid heart model 有权
    使用多物理流体 - 固体心脏模型的医学数据和图像进行高级测量计算和治疗计划的方法和系统

    公开(公告)号：US09129053B2

    公开(公告)日：2015-09-08

    申请号：US13757517

    申请日：2013-02-01

    申请人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

    发明人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

    IPC分类号： G06F19/00 ,  G06T19/00

    CPC分类号： G06F19/3437 ,  G06F19/00 ,  G06T19/00 ,  G06T2210/41 ,  G16H50/50

    摘要： Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.

    摘要翻译： 用于从医学图像和数据计算先进心脏测量的方法和系统; 并且公开了使用患者特定的多物理流体 - 固体心脏模型的治疗计划。 从医学图像患者数据生成左心室和右心室的患者特异性解剖模型。 基于左心室和右心室的患者特异性解剖模型和患者特异性临床数据生成患者特异性计算心脏模型。 计算模型包括生物力学，电生理学和血液动力学。 为了产生患者特异性计算心脏模型，电生理模型的初始患者特异性参数，生物力学模型的初始患者特异性参数和初始患者特异性计算流体动力学（CFD）边界条件被轻微估计。 使用初始患者特异性参数进行耦合的流体结构相互作用（FSI）模拟，并且基于耦合的FSI模拟来改进初始的患者特异性参数。 估计的模型参数然后构成可用于决策的新的高级测量。

    Method and System for Advanced Measurements Computation and Therapy Planning from Medical Data and Images Using a Multi-Physics Fluid-Solid Heart Model
    5.
    发明申请
    Method and System for Advanced Measurements Computation and Therapy Planning from Medical Data and Images Using a Multi-Physics Fluid-Solid Heart Model 有权
    使用多物理流体固体心脏模型的医学数据和图像的高级测量计算和治疗计划的方法和系统

    公开(公告)号：US20130197884A1

    公开(公告)日：2013-08-01

    申请号：US13757517

    申请日：2013-02-01

    申请人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

    发明人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

    IPC分类号： G06F19/00

    CPC分类号： G06F19/3437 ,  G06F19/00 ,  G06T19/00 ,  G06T2210/41 ,  G16H50/50

    摘要： Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.

    摘要翻译： 用于从医学图像和数据计算先进心脏测量的方法和系统; 并且公开了使用患者特定的多物理流体 - 固体心脏模型的治疗计划。 从医学图像患者数据生成左心室和右心室的患者特异性解剖模型。 基于左心室和右心室的患者特异性解剖模型和患者特异性临床数据生成患者特异性计算心脏模型。 计算模型包括生物力学，电生理学和血液动力学。 为了产生患者特异性计算心脏模型，电生理模型的初始患者特异性参数，生物力学模型的初始患者特异性参数和初始患者特异性计算流体动力学（CFD）边界条件被轻微估计。 使用初始患者特异性参数进行耦合的流体结构相互作用（FSI）模拟，并且基于耦合的FSI模拟来改进初始的患者特异性参数。 估计的模型参数然后构成可用于决策的新的高级测量。

    Method and system for hemodynamic assessment of aortic coarctation from medical image data
    6.
    发明授权
    Method and system for hemodynamic assessment of aortic coarctation from medical image data 有权
    医学图像数据主动脉缩窄血流动力学评估方法与系统

    公开(公告)号：US09135699B2

    公开(公告)日：2015-09-15

    申请号：US13826307

    申请日：2013-03-14

    申请人： Kristof Ralovich ,  Lucian Mihai Itu ,  Viorel Mihalef ,  Puneet Sharma ,  Razvan Ioan Ionasec ,  Dime Vitanovski ,  Waldemar Krawtschuk ,  Dorin Comaniciu

    发明人： Kristof Ralovich ,  Lucian Mihai Itu ,  Viorel Mihalef ,  Puneet Sharma ,  Razvan Ioan Ionasec ,  Dime Vitanovski ,  Waldemar Krawtschuk ,  Dorin Comaniciu

    IPC分类号： G06K9/00 ,  G06T7/00

    CPC分类号： G06T7/0012 ,  G06T2207/10076 ,  G06T2207/10096 ,  G06T2207/30104

    摘要： A method and system for non-invasive hemodynamic assessment of aortic coarctation from medical image data, such as magnetic resonance imaging (MRI) data is disclosed. Patient-specific lumen anatomy of the aorta and supra-aortic arteries is estimated from medical image data of a patient, such as contrast enhanced MRI. Patient-specific aortic blood flow rates are estimated from the medical image data of the patient, such as velocity encoded phase-contrasted MRI cine images. Patient-specific inlet and outlet boundary conditions for a computational model of aortic blood flow are calculated based on the patient-specific lumen anatomy, the patient-specific aortic blood flow rates, and non-invasive clinical measurements of the patient. Aortic blood flow and pressure are computed over the patient-specific lumen anatomy using the computational model of aortic blood flow and the patient-specific inlet and outlet boundary conditions.

    摘要翻译： 公开了一种用于从医学图像数据（如磁共振成像（MRI））数据进行主动脉缩窄的非侵入性血流动力学评估的方法和系统。 从患者的医学图像数据估计主动脉和超主动脉血管的患者特异性内腔解剖结构，例如对比度增强的MRI。 根据患者的医学图像数据估计患者特异性主动脉血流速率，例如速度编码的相位对比MRI电影图像。 基于患者特异性内腔解剖，患者特异性主动脉血流速率和患者的非侵入性临床测量，计算主动脉血流计算模型的患者特异性入口和出口边界条件。 使用主动脉血流计算模型和患者特定的入口和出口边界条件，计算患者特异性内腔解剖结构的主动脉血流和压力。

    Method and System for Hemodynamic Assessment of Aortic Coarctation from Medical Image Data
    7.
    发明申请
    Method and System for Hemodynamic Assessment of Aortic Coarctation from Medical Image Data 有权
    医学图像数据主动脉缩窄血流动力学评估方法与系统

    公开(公告)号：US20130243294A1

    公开(公告)日：2013-09-19

    申请号：US13826307

    申请日：2013-03-14

    申请人： Kristof Ralovich ,  Lucian Mihai Itu ,  Viorel Mihalef ,  Puneet Sharma ,  Razvan Ioan Ionasec ,  Dime Vitanovski ,  Waldemar Krawtschuk ,  Dorin Comaniciu

    发明人： Kristof Ralovich ,  Lucian Mihai Itu ,  Viorel Mihalef ,  Puneet Sharma ,  Razvan Ioan Ionasec ,  Dime Vitanovski ,  Waldemar Krawtschuk ,  Dorin Comaniciu

    IPC分类号： G06T7/00

    CPC分类号： G06T7/0012 ,  G06T2207/10076 ,  G06T2207/10096 ,  G06T2207/30104

    摘要： A method and system for non-invasive hemodynamic assessment of aortic coarctation from medical image data, such as magnetic resonance imaging (MRI) data is disclosed. Patient-specific lumen anatomy of the aorta and supra-aortic arteries is estimated from medical image data of a patient, such as contrast enhanced MRI. Patient-specific aortic blood flow rates are estimated from the medical image data of the patient, such as velocity encoded phase-contrasted MRI cine images. Patient-specific inlet and outlet boundary conditions for a computational model of aortic blood flow are calculated based on the patient-specific lumen anatomy, the patient-specific aortic blood flow rates, and non-invasive clinical measurements of the patient. Aortic blood flow and pressure are computed over the patient-specific lumen anatomy using the computational model of aortic blood flow and the patient-specific inlet and outlet boundary conditions.

    摘要翻译： 公开了一种用于从医学图像数据（如磁共振成像（MRI））数据进行主动脉缩窄的非侵入性血流动力学评估的方法和系统。 从患者的医学图像数据估计主动脉和超主动脉血管的患者特异性内腔解剖结构，例如对比度增强的MRI。 根据患者的医学图像数据估计患者特异性主动脉血流速率，例如速度编码的相位对比MRI电影图像。 基于患者特异性内腔解剖，患者特异性主动脉血流速率和患者的非侵入性临床测量，计算主动脉血流计算模型的患者特异性入口和出口边界条件。 使用主动脉血流计算模型和患者特定的入口和出口边界条件，计算患者特异性内腔解剖结构的主动脉血流和压力。

    Method and system for comprehensive patient-specific modeling of the heart
    9.
    发明授权
    Method and system for comprehensive patient-specific modeling of the heart 有权
    心脏综合患者特异性建模的方法和系统

    公开(公告)号：US08682626B2

    公开(公告)日：2014-03-25

    申请号：US13091076

    申请日：2011-04-20

    申请人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

    发明人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

    IPC分类号： G06G7/48

    CPC分类号： G06T13/20 ,  G06F19/321 ,  G06T2210/24 ,  G06T2210/41 ,  G16H50/50

    摘要： A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.

    摘要翻译： 公开了一种用于针对4D医学图像数据的整个心脏解剖结构，动力学，血流动力学和流体结构相互作用的患者特异性建模的方法和系统。 通过从患者的4D医学图像数据估计心脏的生理模型的患者特异性参数来确定心脏的解剖学和动力学。 患者特异性解剖学和动力学被用作3D Navier-Stokes求解器的输入，该解算器在整个心脏周期中导出由局部解剖结构约束的现实血液动力学。 流体结构相互作用是通过在给定的时间步长模拟血液流动而在心脏周期上迭代地确定的，并且基于模拟的血液流量计算心脏结构的变形，使得心脏结构的变形用于模拟 血液流动在下一个时间步。 代表解剖学，动力学，血液动力学和流体结构相互作用的心脏综合患者特异性模型可用于心脏的非侵入性评估和诊断，以及虚拟治疗计划和心血管疾病管理。 全面的患者特异性模型的参数被改变或扰动以模拟各种条件或治疗选择，然后重新计算患者特异性模型以预测条件或治疗选择的影响。

    Method and system for patient-specific hemodynamic assessment of virtual stent implantation
    10.
    发明授权
    Method and system for patient-specific hemodynamic assessment of virtual stent implantation 有权
    虚拟支架植入患者特异性血液动力学评估方法与系统

    公开(公告)号：US08983809B2

    公开(公告)日：2015-03-17

    申请号：US13311989

    申请日：2011-12-06

    申请人： Puneet Sharma ,  Viorel Mihalef ,  Razvan Ioan Ionasec ,  Bogdan Georgescu ,  Dorin Comaniciu

    发明人： Puneet Sharma ,  Viorel Mihalef ,  Razvan Ioan Ionasec ,  Bogdan Georgescu ,  Dorin Comaniciu

    IPC分类号： G06F17/50 ,  G06F19/00 ,  A61F2/90

    CPC分类号： G06F19/3437 ,  A61F2/90 ,  G06F19/00 ,  G06F2217/00 ,  G16H50/50

    摘要： A method and system for assessment of virtual stent implantation in an aortic aneurysm is disclosed. A patient-specific 4D anatomical model of the aorta is generated from the 4D medical imaging data. A model representing mechanical properties of the aorta wall is adjusted to reflect changes due to aneurysm growth at a plurality of time stages. A stable deformation configuration of the aorta is generated for each time stages by performing fluid structure interaction (FSI) simulations using the patient-specific 4D anatomical model at each time stage based on the adjusted model representing the mechanical properties of the aorta wall at each time stage. Virtual stent implantation is performed for each stable deformation configuration of the aorta and FSI simulations are performed for each virtual stent implantation.

    摘要翻译： 公开了一种用于评估主动脉瘤中虚拟支架植入的方法和系统。 从4D医学成像数据生成主动脉的患者特定的4D解剖模型。 调整表示主动脉壁的机械特性的模型，以反映在多个时间段由于动脉瘤生长引起的变化。 通过使用每个时间阶段使用患者特定的4D解剖模型的流体结构相互作用（FSI）模拟，基于每次代表主动脉壁的机械性质的调整模型，对每个时间阶段产生主动脉的稳定变形构型 阶段。 对于主动脉的每个稳定变形构型执行虚拟支架植入，并且对于每个虚拟支架植入进行FSI模拟。