公开(公告)号：US20210166927A1

公开(公告)日：2021-06-03

申请号：US17153156

申请日：2021-01-20

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Linfan Li ,  Xiaoyu Zhou

IPC: H01J49/00 ,  H01J49/04

Abstract: The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed.

公开(公告)号：US10008375B2

公开(公告)日：2018-06-26

申请号：US14426591

申请日：2014-01-10

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Yue Ren ,  Jiangjiang Liu ,  Linfan Li

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/16 ,  H01J49/42

CPC classification number: H01J49/0409 ,  H01J49/0431 ,  H01J49/0459 ,  H01J49/167 ,  H01J49/4205

Abstract: The invention generally relates to systems for analyzing a sample and methods of use thereof. In certain aspects, the invention provides systems that include an ionization probe and a mass analyzer. The probe includes a hollow body that has a distal tip. The probe also includes a substrate that is at least partially disposed within the body and positioned prior to the distal tip so that sample extracted from the substrate flows into the body prior to exiting the distal tip. The probe also includes an electrode that operably interacts with sample extracted from the substrate.

公开(公告)号：US20160181077A1

公开(公告)日：2016-06-23

申请号：US14909269

申请日：2014-08-06

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Linfan Li ,  Xiaoyu Zhou

IPC: H01J49/00 ,  H01J49/04

CPC classification number: H01J49/0031 ,  H01J49/0013 ,  H01J49/004 ,  H01J49/0422

Abstract: The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed.

Abstract translation: 本发明一般涉及使用微型质谱仪的样品分析。 在某些实施方案中，本发明提供涉及产生第一分析物的离子和第二分析物的离子的方法。 这些离子以不连续的样品引入界面在转移期间保持打开的方式通过不连续的样品引入界面转移到质谱仪的第一离子阱中。 关闭不连续的样品引入界面，并将离子顺序地转移到质谱仪的第二离子阱上，在其中依次分析它们。

公开(公告)号：US10930481B2

公开(公告)日：2021-02-23

申请号：US14909269

申请日：2014-08-06

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Linfan Li ,  Xiaoyu Zhou

IPC: H01J49/00 ,  H01J49/04

Abstract: The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed.

公开(公告)号：US20150325423A1

公开(公告)日：2015-11-12

申请号：US14426591

申请日：2014-01-10

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Zheng Ouyang ,  Yue Ren ,  Jiangjiang Liu ,  Linfan Li

IPC: H01J49/16 ,  H01J49/42 ,  H01J49/04

CPC classification number: H01J49/0409 ,  H01J49/0431 ,  H01J49/0459 ,  H01J49/167 ,  H01J49/4205

Abstract: The invention generally relates to systems for analyzing a sample and methods of use thereof. In certain aspects, the invention provides systems that include an ionization probe and a mass analyzer. The probe includes a hollow body that has a distal tip. The probe also includes a substrate that is at least partially disposed within the body and positioned prior to the distal tip so that sample extracted from the substrate flows into the body prior to exiting the distal tip. The probe also includes an electrode that operably interacts with sample extracted from the substrate.

Abstract translation: 本发明一般涉及用于分析样品的系统及其使用方法。 在某些方面，本发明提供了包括电离探针和质量分析器的系统。 探针包括具有远端的中空体。 探针还包括至少部分地设置在体内并且定位在远侧末端之前的基底，使得从基底抽出的样品在离开远侧末端之前流入体内。 探针还包括与从衬底提取的样品可操作地相互作用的电极。