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公开(公告)号：US10008375B2
公开(公告)日：2018-06-26
申请号：US14426591
申请日：2014-01-10
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , Yue Ren , Jiangjiang Liu , Linfan Li
CPC classification number: H01J49/0409 , H01J49/0431 , H01J49/0459 , H01J49/167 , H01J49/4205
Abstract: The invention generally relates to systems for analyzing a sample and methods of use thereof. In certain aspects, the invention provides systems that include an ionization probe and a mass analyzer. The probe includes a hollow body that has a distal tip. The probe also includes a substrate that is at least partially disposed within the body and positioned prior to the distal tip so that sample extracted from the substrate flows into the body prior to exiting the distal tip. The probe also includes an electrode that operably interacts with sample extracted from the substrate.
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2.发明申请SYSTEMS AND METHODS FOR ANALYZING AN EXTRACTED SAMPLE USING AN IMMISCIBLE EXTRACTION SOLVENT 审中-公开使用无溶剂萃取溶剂分析提取样品的系统和方法公开(公告)号：US20160351381A1
公开(公告)日：2016-12-01
申请号：US15113945
申请日：2015-01-30
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Zheng Ouyang , Jiangjiang Liu , Yuen Ren , Morgan McLuckey
CPC classification number: H01J49/167 , B01D11/04 , C12Q1/46 , G01N2333/918 , H01J49/0431
Abstract: The invention generally relates to systems and methods for analyzing an extracted sample using an immiscible extraction solvent. In certain embodiments, the invention provides a system for analyzing an analyte in a sample. The system includes an ionization probe and a mass spectrometer. The ionization probe includes a hollow body that optionally includes a distal tip. The hollow body is configured such that there is no substrate within the body and no electrode disposed on a surface of the body. An electrode is at least partially disposed within the hollow body.
Abstract translation: 本发明一般涉及使用不混溶的提取溶剂分析提取的样品的系统和方法。 在某些实施方案中，本发明提供用于分析样品中的分析物的系统。 该系统包括电离探针和质谱仪。 电离探针包括可选地包括远端的中空体。 中空体被构造成使得在体内不存在基底，并且没有电极设置在身体的表面上。 电极至少部分地设置在中空体内。
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公开(公告)号：US09116154B2
公开(公告)日：2015-08-25
申请号：US14561531
申请日：2014-12-05
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
Abstract translation: 本发明一般涉及用于质谱分析样品的系统和方法。 在某些实施方案中，本发明提供了一种质谱探针，其包括连接到高电压源的至少一种多孔材料，其中多孔材料与溶剂流离散。
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公开(公告)号：US20150122987A1
公开(公告)日：2015-05-07
申请号：US14561531
申请日：2014-12-05
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
Abstract translation: 本发明一般涉及用于质谱分析样品的系统和方法。 在某些实施方案中，本发明提供了一种质谱探针，其包括连接到高电压源的至少一种多孔材料，其中多孔材料与溶剂流离散。
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公开(公告)号：US08890063B2
公开(公告)日：2014-11-18
申请号：US13727177
申请日：2012-12-26
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
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Patent Agency Ranking
公开(公告)号：US08859959B2
公开(公告)日：2014-10-14
申请号：US13727173
申请日：2012-12-26
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
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公开(公告)号：US11867684B2
公开(公告)日：2024-01-09
申请号：US17584100
申请日：2022-01-25
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/492 , G01N1/28 , G01N1/286 , G01N33/48714 , G01N33/48785 , G01N33/491 , H01J49/0009 , H01J49/0027 , H01J49/16 , G01N1/10 , G01N2001/2893
Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.
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8.发明授权公开(公告)号：US09500572B2
公开(公告)日：2016-11-22
申请号：US13784094
申请日：2013-03-04
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/492 , G01N1/10 , G01N1/28 , G01N1/286 , G01N33/48714 , G01N33/48785 , G01N33/491 , G01N2001/2893 , H01J49/0009 , H01J49/0027 , H01J49/16
Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof. In certain embodiments, the invention provides a fluid dispenser that includes a fluid chamber. A portion of an inner wall of the chamber includes an internal standard. The chamber is configured such that fluid introduced to the chamber must interact with the portion of the chamber wall that includes the internal standard prior to flowing through an outlet of the chamber. The dispenser additionally includes a member coupled to the chamber such that it can control movement of fluid within the chamber.
Abstract translation: 本发明一般涉及一种包括内部标准的样品分配器及其使用方法。 在某些实施例中，本发明提供一种包括流体室的流体分配器。 室的内壁的一部分包括内标。 腔室被配置成使得引入腔室的流体必须在流过腔室的出口之前与包括内部标准的腔室壁的部分相互作用。 分配器还包括联接到室的构件，使得其可以控制腔室内的流体的运动。
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公开(公告)号：US08859958B2
公开(公告)日：2014-10-14
申请号：US13727167
申请日：2012-12-26
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
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公开(公告)号：US08816275B2
公开(公告)日：2014-08-26
申请号：US14023531
申请日：2013-09-11
Applicant: Purdue Research Foundation
Inventor： Zheng Ouyang , He Wang , Nicholas E. Manicke , Robert Graham Cooks , Qian Yang , Jiangjiang Liu
CPC classification number: G01N33/6848 , G01N1/00 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0431 , H01J49/16 , H01J49/168
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
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