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    Systems and methods for quantifying an analyte extracted from a sample
    1.
    发明授权
    Systems and methods for quantifying an analyte extracted from a sample 有权

    公开(公告)号：US11875983B2

    公开(公告)日：2024-01-16

    申请号：US17979972

    申请日：2022-11-03

    Applicant: Purdue Research Foundation

    Inventor： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

    IPC: H01J49/16 ,  H01J49/04 ,  C12Q1/6806

    CPC classification number: H01J49/167 ,  C12Q1/6806 ,  Y10T436/24 ,  Y10T436/255

    Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

    SYSTEMS AND METHODS FOR QUANTIFYING AN ANALYTE EXTRACTED FROM A SAMPLE
    4.
    发明申请
    SYSTEMS AND METHODS FOR QUANTIFYING AN ANALYTE EXTRACTED FROM A SAMPLE 审中-公开
    从样品中提取分析物的系统和方法

    公开(公告)号：US20160201051A1

    公开(公告)日：2016-07-14

    申请号：US15064865

    申请日：2016-03-09

    Applicant: Purdue Research Foundation

    Inventor： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

    IPC: C12N15/10 ,  H01J49/04 ,  H01J49/16 ,  C12Q1/68

    CPC classification number: H01J49/167 ,  C12Q1/6806 ,  Y10T436/24 ,  Y10T436/255

    Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

    Abstract translation: 本发明一般涉及用于量化从样品中提取的分析物的系统和方法。 在某些实施方案中，本发明提供了将溶剂引入毛细管中的方法，将毛细管引入包含样品的容器中，使得将样品的一部分引入毛细管中，使样品和溶剂在毛细管内移动以诱导 在样品和溶剂中循环，从而使分析物从样品中提取并进入溶剂中，分析从样品中提取的分析物，并对分析物进行定量。 在某些实施方案中，在不知道样品和/或溶剂的体积的情况下进行定量步骤。

    SYSTEMS AND METHODS FOR QUANTIFYING AN ANALYTE EXTRACTED FROM A SAMPLE
    5.
    发明公开
    SYSTEMS AND METHODS FOR QUANTIFYING AN ANALYTE EXTRACTED FROM A SAMPLE 审中-公开

    公开(公告)号：US20240162026A1

    公开(公告)日：2024-05-16

    申请号：US18526244

    申请日：2023-12-01

    Applicant: Purdue Research Foundation

    Inventor： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

    IPC: H01J49/16 ,  C12Q1/6806

    CPC classification number: H01J49/167 ,  C12Q1/6806 ,  Y10T436/24 ,  Y10T436/255

    Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

    Systems and methods for quantifying an analyte extracted from a sample
    7.
    发明授权
    Systems and methods for quantifying an analyte extracted from a sample 有权

    公开(公告)号：US10269550B2

    公开(公告)日：2019-04-23

    申请号：US15064865

    申请日：2016-03-09

    Applicant: Purdue Research Foundation

    Inventor： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

    IPC: H01J49/04 ,  H01J49/16 ,  C12N15/10 ,  C12Q1/68 ,  C12Q1/6806

    Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

    SYSTEMS AND METHODS FOR ANALYZING AN EXTRACTED SAMPLE
    8.
    发明申请
    SYSTEMS AND METHODS FOR ANALYZING AN EXTRACTED SAMPLE 有权
    用于分析提取样品的系统和方法

    公开(公告)号：US20150325423A1

    公开(公告)日：2015-11-12

    申请号：US14426591

    申请日：2014-01-10

    Applicant: PURDUE RESEARCH FOUNDATION

    Inventor： Zheng Ouyang ,  Yue Ren ,  Jiangjiang Liu ,  Linfan Li

    IPC: H01J49/16 ,  H01J49/42 ,  H01J49/04

    CPC classification number: H01J49/0409 ,  H01J49/0431 ,  H01J49/0459 ,  H01J49/167 ,  H01J49/4205

    Abstract: The invention generally relates to systems for analyzing a sample and methods of use thereof. In certain aspects, the invention provides systems that include an ionization probe and a mass analyzer. The probe includes a hollow body that has a distal tip. The probe also includes a substrate that is at least partially disposed within the body and positioned prior to the distal tip so that sample extracted from the substrate flows into the body prior to exiting the distal tip. The probe also includes an electrode that operably interacts with sample extracted from the substrate.

    Abstract translation: 本发明一般涉及用于分析样品的系统及其使用方法。 在某些方面，本发明提供了包括电离探针和质量分析器的系统。 探针包括具有远端的中空体。 探针还包括至少部分地设置在体内并且定位在远侧末端之前的基底，使得从基底抽出的样品在离开远侧末端之前流入体内。 探针还包括与从衬底提取的样品可操作地相互作用的电极。

    SYSTEMS AND METHODS FOR QUANTIFYING AN ANALYTE EXTRACTED FROM A SAMPLE
    9.
    发明公开
    SYSTEMS AND METHODS FOR QUANTIFYING AN ANALYTE EXTRACTED FROM A SAMPLE 审中-公开

    公开(公告)号：US20230230827A1

    公开(公告)日：2023-07-20

    申请号：US17979972

    申请日：2022-11-03

    Applicant: Purdue Research Foundation

    Inventor： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

    IPC: H01J49/16 ,  C12Q1/6806

    CPC classification number: H01J49/167 ,  C12Q1/6806 ,  Y10T436/24 ,  Y10T436/255

    Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

    Systems and methods for quantifying an analyte extracted from a sample
    10.
    发明授权
    Systems and methods for quantifying an analyte extracted from a sample 有权

    公开(公告)号：US11495448B2

    公开(公告)日：2022-11-08

    申请号：US16985553

    申请日：2020-08-05

    Applicant: Purdue Research Foundation

    Inventor： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

    IPC: H01J49/04 ,  H01J49/16 ,  C12Q1/6806

    Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

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