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公开(公告)号：US20210386986A1
公开(公告)日：2021-12-16
申请号：US17344362
申请日：2021-06-10
发明人： Chi Hwan Lee , Yoon Yeo , Dong Rip Kim
IPC分类号： A61M37/00
摘要： Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.
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公开(公告)号：US11793982B2
公开(公告)日：2023-10-24
申请号：US17344362
申请日：2021-06-10
发明人： Chi Hwan Lee , Yoon Yeo , Dong Rip Kim
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2205/0244
摘要： Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.
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公开(公告)号：US20210353923A1
公开(公告)日：2021-11-18
申请号：US17277427
申请日：2019-09-27
发明人： Chi Hwan Lee , Dong Rip Kim
IPC分类号： A61M37/00
摘要： Devices for intracellular and intratissue nanoinjection of biomolecules into a living body and methods of producing the devices. Such a device includes a flexible substrate and nanoneedles extending from a surface of the flexible substrate, and can be produced by providing a first substrate having pillars extending from a surface thereof, locally reducing diameters of the pillars at locations thereof adjacent the first substrate, embedding distal ends of the pillars in a flexible substrate, and sufficiently expanding the flexible substrate to cause the pillars to fracture at the locations thereof adjacent the first substrate and detach therefrom to define nanoneedles extending from the flexible substrate.
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公开(公告)号：US11518675B2
公开(公告)日：2022-12-06
申请号：US17126316
申请日：2020-12-18
摘要： Nanoassembly methods for producing quasi-3D plasmonic films with periodic nanoarrays of nano-sized surface features. A sacrificial layer is deposited on a surface of a donor substrate having periodic nanoarrays of nanopattern features formed thereon. A plasmon film is deposited onto the sacrificial layer and a dielectric spacer is deposited on the plasmon film. The donor substrate having the sacrificial layer, plasmon film, and dielectric spacer thereon is immersed in a bath of etchant to selectively remove the sacrificial layer such that the plasmon film and the dielectric spacer thereon adhere to the surface of the donor substrate. The dielectric spacer and the plasmon film are mechanically separated from the donor substrate to define a quasi-three dimensional (3D) plasmonic film having periodic nanoarrays of nano-sized surface features defined by the nanopattern features of the donor substrate surface. The quasi-3D plasmonic film is then applied to a receiver substrate.
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公开(公告)号：US20220223457A1
公开(公告)日：2022-07-14
申请号：US17613804
申请日：2020-05-29
发明人： Chi Hwan Lee
摘要： Interfacial delamination processes for physically separating a film structure from a substrate, and processes of fabricating a thin-film electronic device. The processes entail providing the substrate with an electrically-conductive separation layer on a surface of the substrate and optionally providing a pin hole free barrier layer on the electrically-conductive separation layer, forming a film structure on the electrically-conductive separation layer or, if present, the barrier layer, to yield a multilayer structure, and separating the film structure from the substrate by subjecting the multilayer structure to interfacial debonding that comprises contacting at least an interface between the film structure and the electrically-conductive separation layer or, if present, the barrier layer, with water or an electrolyte solution.
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公开(公告)号：US11802043B2
公开(公告)日：2023-10-31
申请号：US18061052
申请日：2022-12-02
CPC分类号： B82B3/0014 , G02B5/008 , B82Y30/00 , B82Y40/00 , G02B2207/101
摘要： Nanoassembly methods for producing quasi-3D plasmonic films with periodic nanoarrays of nano-sized surface features. A sacrificial layer is deposited on a surface of a donor substrate having periodic nanoarrays of nanopattern features formed thereon. A plasmon film is deposited onto the sacrificial layer and a dielectric spacer is deposited on the plasmon film. The donor substrate having the sacrificial layer, plasmon film, and dielectric spacer thereon is immersed in a bath of etchant to selectively remove the sacrificial layer such that the plasmon film and the dielectric spacer thereon adhere to the surface of the donor substrate. The dielectric spacer and the plasmon film are mechanically separated from the donor substrate to define a quasi-three dimensional (3D) plasmonic film having periodic nanoarrays of nano-sized surface features defined by the nanopattern features of the donor substrate surface. The quasi-3D plasmonic film is then applied to a receiver substrate.
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公开(公告)号：US20220004026A1
公开(公告)日：2022-01-06
申请号：US17365734
申请日：2021-07-01
摘要： A device includes a contact lens, a corneal sensor that includes a circular trace of conduction paths located at or near an outer peripheral edge of the contact lens that surrounds an unobstructed area at a center region of the contact lens, and a connection wire coupled to the corneal sensor and configured to electrically couple to an external data acquisition system. Methods of fabricating the device may include providing a thin device that includes a sensor and a connection wire coupled to the sensor, transferring the sensor to a curvilinear inner surface of a contact lens, feeding the connection wire through the inner surface of the contact lens and out of an outer surface of the contact lens, and performing electrochemical polymerization of a conducting polymer material over the sensor to anchor the sensor to the inner surface of the contact lens.
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公开(公告)号：US11000082B2
公开(公告)日：2021-05-11
申请号：US15902039
申请日：2018-02-22
发明人： Chi Hwan Lee , Min Ku Kim
IPC分类号： A61F2/58 , A41D19/00 , A41D1/00 , A41D31/00 , B32B1/00 , B32B25/14 , G01L1/20 , G01L1/22 , A61F2/76 , A61F2/50 , G01K7/16 , G01N27/22
摘要： Electronic assistive gloves for covering artificial prosthetic or robotic hands. The glove includes a base layer formed to fit on the artificial hand, a plurality of sensors carried by the base layer, and an encapsulation layer covering the base layer and formed of a material that mimics human skin.
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公开(公告)号：US12075564B2
公开(公告)日：2024-08-27
申请号：US17823021
申请日：2022-08-29
IPC分类号： H05K1/03 , A61B5/27 , D06B11/00 , D06M11/65 , D06M11/83 , D06M15/693 , D06M23/08 , H01B3/28 , H05K1/09 , H05K3/14 , D06M101/06 , D06M101/32 , D06M101/38
CPC分类号： H05K1/038 , A61B5/27 , D06B11/0059 , D06M11/65 , D06M11/83 , D06M15/693 , D06M23/08 , H01B3/28 , H05K1/092 , H05K3/14 , A61B2503/40 , A61B2562/0215 , A61B2562/0285 , D06M2101/06 , D06M2101/32 , D06M2101/38 , D10B2201/02 , D10B2331/04 , D10B2331/10 , D10B2401/16 , H05K2201/10151
摘要： Electronic textiles and methods of fabrication electronic textiles. Nanoparticles of a conductive material are sprayed along a conductive path into a fabric material so as to penetrate into the fabric. A layer of a second conductor material is coated over the nanoparticles along the conductive path. A layer of an insulator material is coated over the layer of the second conductor material so as to encapsulate the conductive path and form a trace. An electrode configured to contact a subject wearing the fabric material includes a layer of a third conductor material coated over the layer of the second conductor and electrically coupled with the conductive path. An electrical connector is secured to the fabric material and electrically coupled with the conductive path. The nanoparticles are sprayed onto the fabric material using a dual regime spray process implemented with a dual regime spray system.
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公开(公告)号：US20220363860A1
公开(公告)日：2022-11-17
申请号：US17742186
申请日：2022-05-11
发明人： Craig J. Goergen , Chi Hwan Lee , Bongjoong Kim , Kwan-Soo Lee
摘要： Poroelastic materials, methods of making such materials, biosensors comprising such materials, and methods of making and using such biosensors. According to one aspect, a poroelastic material is formed by a process that includes depositing a prepolymer composition on a substrate, annealing the prepolymer composition in a pressurized steam environment at a temperature and for a duration sufficient to form a porous medium having a solid matrix formed of a polymer derived from the prepolymer composition, infiltrating the porous medium with a liquid that includes electrically conductive nanomaterials such that the electrically conductive nanomaterials are located within pores of the porous medium, and evaporating the liquid such that the electrically conductive nanomaterials remain in and/or connected through the pores of the porous medium.
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