公开(公告)号：US20190022415A1

公开(公告)日：2019-01-24

申请号：US16116388

申请日：2018-08-29

Applicant: Pyramid Technical Consultants Inc.

Inventor： Raymond Paul Boisseau ,  William P. Nett ,  John S. Gordon ,  Sashidar Kollipara ,  Yuriy Kozlov

IPC: A61N5/10

CPC classification number: A61N5/1067 ,  A61N5/1043 ,  A61N5/1071 ,  A61N2005/1087

Abstract: The present disclosure is directed to systems and methods for real-time control of a charged particle pencil beam system during therapeutic treatment of a patient. In an aspect, the present disclosure is directed to measuring an actual shape, an actual intensity distribution, and an actual location at isocenter of the charged particle pencil beam. The actual data is compared to model treatment data in real time to determine if a statistically significant variance occurs in which case the charged particle pencil beam can be stopped mid-treatment for correction and/or analysis.

公开(公告)号：US10195465B2

公开(公告)日：2019-02-05

申请号：US15840604

申请日：2017-12-13

Applicant: Pyramid Technical Consultants Inc.

Inventor： John Stuart Gordon ,  Raymond Paul Boisseau

IPC: A61N5/10

Abstract: A control system for fine tuning or spreading a charged particle pencil beam includes a low-inductance, low-power compensation or fine-tuning magnet assembly. The feedback loop that includes the compensation magnet assembly has a faster response rate than the feedback loop that includes the scan nozzle. The compensation or fine-tuning magnet assembly is preferably disposed upstream of the scan nozzle magnet(s) with respect to the beam path to make rapid but minor adjustments to the beam position between iterations of the scan nozzle.

公开(公告)号：US20200298022A1

公开(公告)日：2020-09-24

申请号：US16358044

申请日：2019-03-19

Applicant: Pyramid Technical Consultants Inc.

Inventor： John Gordon ,  Andrew Dart ,  Raymond Paul Boisseau

IPC: A61N5/10

Abstract: A pencil beam system includes a charged particle beam generator, a transport beamline apparatus, a scan nozzle, a fast deflector electromagnet, and a controller. After a therapeutic dose is delivered to a first target spot, the fast deflector electromagnet generates a first magnetic field that causes the net deflection of the charged particle beam to transition from the first target spot to an adjacent target spot. After the charged particle beam is directed to the adjacent target spot, the controller simultaneously adjusts the first magnetic field and the scan nozzle magnetic field to reduce and eliminate the contribution of the first magnetic field to the net deflection. The fast deflector electromagnet is deliberately designed with limited magnetic field and limited deflecting power to provide a higher slew rate, faster settling and less hysteresis contribution to beam position as compared to the scan nozzle electromagnets.

公开(公告)号：US10300304B2

公开(公告)日：2019-05-28

申请号：US15904571

申请日：2018-02-26

Applicant: Pyramid Technical Consultants Inc.

Inventor： William P. Nett ,  John Gordon ,  Raymond Paul Boisseau

IPC: H01J37/244 ,  A61N5/00 ,  A61N5/10 ,  H01J37/24

Abstract: An assembly for preventing an overdose of a charged particle beam during therapy to a patient includes a pixelated detector apparatus and a controller. The controller includes, for each pixel: a current integrator circuit that converts the local measured current into a total local detected charge integrated from a start time, the integrator circuit outputting an integrator voltage that corresponds to the total local detected charge; and a discriminator circuit that compares the integrator voltage with a reference voltage, the reference voltage corresponding to a maximum acceptable dose for the patient. A logic circuit generates an overdose fault signal if, at any of the pixels, the integrator voltage is higher than the reference voltage.

公开(公告)号：US20180289984A1

公开(公告)日：2018-10-11

申请号：US15904571

申请日：2018-02-26

Applicant: Pyramid Technical Consultants Inc.

Inventor： William P. Nett ,  John Gordon ,  Raymond Paul Boisseau

IPC: A61N5/10 ,  H01J37/244 ,  H01J37/24

CPC classification number: A61N5/1064 ,  A61N5/1071 ,  A61N2005/1087 ,  H01J37/243 ,  H01J37/244 ,  H01J2237/24564 ,  H01J2237/2485

Abstract: An assembly for preventing an overdose of a charged particle beam during therapy to a patient includes a pixelated detector apparatus and a controller. The controller includes, for each pixel: a current integrator circuit that converts the local measured current into a total local detected charge integrated from a start time, the integrator circuit outputting an integrator voltage that corresponds to the total local detected charge; and a discriminator circuit that compares the integrator voltage with a reference voltage, the reference voltage corresponding to a maximum acceptable dose for the patient. A logic circuit generates an overdose fault signal if, at any of the pixels, the integrator voltage is higher than the reference voltage.

公开(公告)号：US20170319873A1

公开(公告)日：2017-11-09

申请号：US15146541

申请日：2016-05-04

Applicant: Pyramid Technical Consultants Inc.

Inventor： Raymond Paul Boisseau ,  John Gordon ,  William P. Nett ,  Kan Ota

IPC: A61N5/10

CPC classification number: A61N5/1067 ,  A61N5/1043 ,  A61N5/1048 ,  A61N2005/1074 ,  A61N2005/1087

Abstract: A control system for providing a closed loop, real time control of a charged particle pencil beam is disclosed. The system includes a first detector apparatus, a second detector apparatus, a first orthogonal magnetic deflector apparatus, a second orthogonal magnetic deflector apparatus, and a controller. The controller compares the measured position and beam angle of the beam with a model position and beam angle of a model beam to determine an offset error and a beam angle error. The first orthogonal magnetic deflector apparatus includes a pair of electromagnets to correct a first component of the offset and beam angle errors. The second orthogonal magnetic deflector apparatus includes a pair of electromagnets to correct a second component of the offset and beam angle errors. The beam can be iteratively adjusted during patient therapy or short pauses in patient therapy.

公开(公告)号：US20150087885A1

公开(公告)日：2015-03-26

申请号：US14493098

申请日：2014-09-22

Applicant: Pyramid Technical Consultants, Inc.

Inventor： Raymond Paul Boisseau ,  William P. Nett ,  John S. Gordon ,  Sashidar Kollipara ,  Yuriy Kozlov

IPC: A61N5/10

CPC classification number: A61N5/1067 ,  A61N5/1043 ,  A61N5/1071 ,  A61N2005/1087

Abstract: The present disclosure is directed to systems and methods for real-time control of a charged particle pencil beam system during therapeutic treatment of a patient. In an aspect, the present disclosure is directed to measuring an actual shape, an actual intensity distribution, and an actual location at isocenter of the charged particle pencil beam. The actual data is compared to model treatment data in real time to determine if a statistically significant variance occurs in which case the charged particle pencil beam can be stopped mid-treatment for correction and/or analysis.

Abstract translation: 本公开涉及用于在患者的治疗性治疗期间实时控制带电粒子笔束系统的系统和方法。 在一方面，本公开涉及测量带电粒子束的等角点处的实际形状，实际强度分布和实际位置。 将实际数据与实时模型处理数据进行比较，以确定是否发生统计显着的方差，在这种情况下，带电粒子笔束可以停止中间处理以进行校正和/或分析。

公开(公告)号：US10456598B2

公开(公告)日：2019-10-29

申请号：US16116388

申请日：2018-08-29

Applicant: Pyramid Technical Consultants Inc.

Inventor： Raymond Paul Boisseau ,  William P. Nett ,  John S. Gordon ,  Sashidar Kollipara ,  Yuriy Kozlov

IPC: A61N5/10

Abstract: The present disclosure is directed to systems and methods for real-time control of a charged particle pencil beam system during therapeutic treatment of a patient. In an aspect, the present disclosure is directed to measuring an actual shape, an actual intensity distribution, and an actual location at isocenter of the charged particle pencil beam. The actual data is compared to model treatment data in real time to determine if a statistically significant variance occurs in which case the charged particle pencil beam can be stopped mid-treatment for correction and/or analysis.

公开(公告)号：US10183178B2

公开(公告)日：2019-01-22

申请号：US15146541

申请日：2016-05-04

Applicant: Pyramid Technical Consultants Inc.

Inventor： Raymond Paul Boisseau ,  John Gordon ,  William P. Nett ,  Kan Ota

IPC: A61N5/10

Abstract: A control system for providing a closed loop, real time control of a charged particle pencil beam is disclosed. The system includes a first detector apparatus, a second detector apparatus, a first orthogonal magnetic deflector apparatus, a second orthogonal magnetic deflector apparatus, and a controller. The controller compares the measured position and beam angle of the beam with a model position and beam angle of a model beam to determine an offset error and a beam angle error. The first orthogonal magnetic deflector apparatus includes a pair of electromagnets to correct a first component of the offset and beam angle errors. The second orthogonal magnetic deflector apparatus includes a pair of electromagnets to correct a second component of the offset and beam angle errors. The beam can be iteratively adjusted during patient therapy or short pauses in patient therapy.

公开(公告)号：US10092777B2

公开(公告)日：2018-10-09

申请号：US15593027

申请日：2017-05-11

Applicant: Pyramid Technical Consultants Inc.

Inventor： Raymond Paul Boisseau ,  William P. Nett ,  John S. Gordon ,  Sashidar Kollipara ,  Yuriy Kozlov

IPC: A61N5/10 ,  G01N23/22 ,  H01J37/09

Abstract: The present disclosure is directed to systems and methods for real-time control of a charged particle pencil beam system during therapeutic treatment of a patient. In an aspect, the present disclosure is directed to measuring an actual shape, an actual intensity distribution, and an actual location at isocenter of the charged particle pencil beam. The actual data is compared to model treatment data in real time to determine if a statistically significant variance occurs in which case the charged particle pencil beam can be stopped mid-treatment for correction and/or analysis.