摘要:
A pharmaceutical combination comprising (a) a compound of formula (I), or pharmaceutically acceptable salts thereof; and (b) one or more at least one compound targeting, decreasing or inhibiting the intrinsic ATPase activity of Hsp90 and/or degrading, targeting, decreasing or inhibiting the Hsp90 client proteins via the ubiquitin proteosome pathway; the uses of such combination in the treatment or prevention of proliferative diseases; and methods of treating a subject suffering.
摘要:
A pharmaceutical combination comprising (a) an ALK inhibitor, or a pharmaceutically acceptable salt thereof, and (b) at least one HDMA-2/p53 receptor inhibitor or a pharmaceutically acceptable salt, or at least one BRaf inhibitor or a pharmaceutically acceptable salt, and optionally a pharmaceutically acceptable carrier, for simultaneous, separate or sequential administration; the uses of such combination in the treatment of cancer; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.
摘要:
The disclosure relates to a pharmaceutical combination of a mdm2/4 inhibitor, namely (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one or (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one, and a cyclin dependent kinase 4/6 (CDK4/6) inhibitor 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide. In addition, the disclosure relates to a pharmaceutical combination product. The disclosure also relates to corresponding pharmaceutical formulations, uses and treatment methods comprising said mdm2/4 inhibitor or a cyclin dependent kinase 4/6 (CDK4/6) inhibitor.
摘要:
FIG. 1 is a perspective view of a mobile phone holder showing my new design; FIG. 2 is another perspective view thereof; FIG. 3 is a front view thereof; FIG. 4 is a rear view thereof; FIG. 5 is a left side view thereof; FIG. 6 is a right side view thereof; FIG. 7 is a top view thereof; FIG. 8 is a bottom view thereof; and, FIG. 9 is a perspective view of the mobile phone holder, shown in another using configuration. The dash-dash broken lines in the drawings depict portions of the mobile phone holder that form no part of the claimed design.
摘要:
A method and a system for a comprehensive analysis of low frequency oscillation. The method includes: firstly, initiating a wide area measurement system WAMS (71) to perform real-time monitoring; transmitting real-time low frequency oscillation information to a dynamic early-warning system (72) periodically; then converting the low frequency oscillation information received by the dynamic early-warning system (72) into an input file for stability calculation with small disturbance, and performing related calculation; finally, transmitting the calculated result back to the wide area measurement system WAMS (71) and a human-machine system interface for output. The system includes: the wide area measurement system WAMS (71), the dynamic early-warning system (72), a system for stability calculation with small disturbance (73) and an output system (74).
摘要:
A method for providing a user interface includes creating a representative image of a media content, displaying the representative image on a screen, making the representative image a movable object on the screen, monitoring a motion gesture to move the representative image, and performing a corresponding action based on the motion gesture. The action includes saving, deleting, sending, or rejecting a message including the representative image and the media content or a link to the media content.
摘要:
The present invention provides a tool for and method of using an infrared transmission technique to extract the full stress components of the in-plane residual stresses in thin, multi crystalline silicon wafers including in situ measurement of residual stress for large cast wafers. The shear difference method is used to obtain full stress components by integrating the shear stress map from the boundaries. System ambiguity at the boundaries is resolved completely by introducing a new analytical function. A new anisotropic stress optic law is provided, and stress optic coefficients are calibrated for different crystal grain orientations and stress orientations.
摘要:
A limited protection method for charging/discharging current of hybrid electric vehicle battery and a device and a system thereof is disclosed. Said method includes: receiving a power requirement and determining an original torque based on the power requirement; judging a charge/discharge state of the battery and acquiring a limited torque from an actual current and a predefined torque; comparing said original torque with the limited torque to select the smaller one as a final output requirement. The embody of the invention can achieve the real-time limited protection for charge/discharge current of hybrid electric vehicle battery.
摘要:
Described herein is the use of a modified human chemokine, GS-CXCL8(3-72)K11R/G31P or G31P in the treatment of a number of cancers, including but by no means limited to prostate cancer, liver cancer and melanoma.
摘要:
Cutting fluids for brittle materials, e.g., silicon ingot, comprise, in weight percent: A. 70-99% polyalkylene glycol (PAG), e.g., polyethylene glycol; B. 0.01-10% PAG-grafted polycarboxylate; and C. 0-30% water. These cutting fluids are used with abrasive materials, e.g., silicon carbide (SiC), to form cutting slurries. The slurry is sprayed on the cutting tool, e.g., a wire saw, to cut a brittle work piece, e.g., a silicon ingot.
摘要翻译:用于脆性材料例如硅锭的切削液包含重量百分比:A.70-99%的聚亚烷基二醇(PAG),例如聚乙二醇; B. 0.01-10%PAG接枝的聚羧酸酯; 和0-30%的水。 这些切削液与研磨材料(例如碳化硅(SiC))一起使用以形成切割浆料。 将浆料喷涂在切割工具,例如线锯上,以切割脆性工件,例如硅锭。