Pharmaceutical Combinations
    2.
    发明申请
    Pharmaceutical Combinations 审中-公开
    药物组合

    公开(公告)号:US20160339023A1

    公开(公告)日:2016-11-24

    申请号:US15107232

    申请日:2014-12-19

    IPC分类号: A61K31/506 A61K31/496

    摘要: A pharmaceutical combination comprising (a) an ALK inhibitor, or a pharmaceutically acceptable salt thereof, and (b) at least one HDMA-2/p53 receptor inhibitor or a pharmaceutically acceptable salt, or at least one BRaf inhibitor or a pharmaceutically acceptable salt, and optionally a pharmaceutically acceptable carrier, for simultaneous, separate or sequential administration; the uses of such combination in the treatment of cancer; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

    摘要翻译: 一种药物组合,其包含(a)ALK抑制剂或其药学上可接受的盐,和(b)至少一种HDMA-2 / p53受体抑制剂或其药学上可接受的盐,或至少一种BRaf抑制剂或药学上可接受的盐, 和任选的药学上可接受的载体,用于同时,分别或连续施用; 这种组合在治疗癌症中的用途; 以及治疗患有增殖性疾病的受试者的方法,包括施用治疗有效量的这种组合。

    PHARMACEUTICAL COMPOSITIONS
    3.
    发明申请
    PHARMACEUTICAL COMPOSITIONS 审中-公开
    药物组合物

    公开(公告)号:US20160331751A1

    公开(公告)日:2016-11-17

    申请号:US15106886

    申请日:2014-12-19

    摘要: The disclosure relates to a pharmaceutical combination of a mdm2/4 inhibitor, namely (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one or (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one, and a cyclin dependent kinase 4/6 (CDK4/6) inhibitor 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide. In addition, the disclosure relates to a pharmaceutical combination product. The disclosure also relates to corresponding pharmaceutical formulations, uses and treatment methods comprising said mdm2/4 inhibitor or a cyclin dependent kinase 4/6 (CDK4/6) inhibitor.

    摘要翻译: 本公开涉及mdm2 / 4抑制剂的药物组合,即(S)-1-(4-氯 - 苯基)-7-异丙氧基-6-甲氧基-2-(4- {甲基 - [4-(4 - 甲基-3-氧代 - 哌嗪-1-基) - 反式 - 环己基甲基] - 氨基} - 苯基)-1,4-二氢-2H-异喹啉-3-酮或(S)-5-(5-氯 - -1-甲基-2-氧代-1,2-二氢 - 吡啶-3-基)-6-(4-氯 - 苯基)-2-(2,4-二甲氧基 - 嘧啶-5-基)-1-异丙基 -5,6-二氢-1H-吡咯并[3,4-d]咪唑-4-酮和细胞周期蛋白依赖性激酶4/6(CDK4 / 6)抑制剂7-环戊基-2-(5-哌嗪-1-基) 吡啶-2-基氨基)-7H-吡咯并[2,3-d]嘧啶-6-甲酸二甲基酰胺。 此外,本公开涉及药物组合产品。 本公开还涉及包含所述mdm2 / 4抑制剂或细胞周期蛋白依赖性激酶4/6(CDK4 / 6)抑制剂的相应药物制剂,用途和治疗方法。

    Mobile phone holder
    4.
    外观设计

    公开(公告)号:USD1045841S1

    公开(公告)日:2024-10-08

    申请号:US29948678

    申请日:2024-06-21

    申请人: Fang Li

    设计人: Fang Li

    摘要: FIG. 1 is a perspective view of a mobile phone holder showing my new design;
    FIG. 2 is another perspective view thereof;
    FIG. 3 is a front view thereof;
    FIG. 4 is a rear view thereof;
    FIG. 5 is a left side view thereof;
    FIG. 6 is a right side view thereof;
    FIG. 7 is a top view thereof;
    FIG. 8 is a bottom view thereof; and,
    FIG. 9 is a perspective view of the mobile phone holder, shown in another using configuration.
    The dash-dash broken lines in the drawings depict portions of the mobile phone holder that form no part of the claimed design.

    Method and system for a comprehensive analysis of low frequency oscillation
    5.
    发明授权
    Method and system for a comprehensive analysis of low frequency oscillation 有权
    低频振荡综合分析方法与系统

    公开(公告)号:US08898027B2

    公开(公告)日:2014-11-25

    申请号:US12996896

    申请日:2009-09-04

    IPC分类号: G01R23/00 H02J3/24

    CPC分类号: H02J3/24

    摘要: A method and a system for a comprehensive analysis of low frequency oscillation. The method includes: firstly, initiating a wide area measurement system WAMS (71) to perform real-time monitoring; transmitting real-time low frequency oscillation information to a dynamic early-warning system (72) periodically; then converting the low frequency oscillation information received by the dynamic early-warning system (72) into an input file for stability calculation with small disturbance, and performing related calculation; finally, transmitting the calculated result back to the wide area measurement system WAMS (71) and a human-machine system interface for output. The system includes: the wide area measurement system WAMS (71), the dynamic early-warning system (72), a system for stability calculation with small disturbance (73) and an output system (74).

    摘要翻译: 一种综合分析低频振荡的方法和系统。 该方法包括:首先启动广域测量系统WAMS(71)进行实时监控; 周期性地将实时低频振荡信息发送到动态预警系统(72); 然后将由动态预警系统(72)接收的低频振荡信息转换成具有小干扰的用于稳定性计算的输入文件,并执行相关计算; 最后,将计算结果传送回广域测量系统WAMS(71)和人机界面进行输出。 该系统包括:广域测量系统WAMS(71),动态预警系统(72),小干扰稳定计算系统(73)和输出系统(74)。

    USING MOTION GESTURES TO SEND, SAVE, DELETE, AND REJECT A MESSAGE
    6.
    发明申请
    USING MOTION GESTURES TO SEND, SAVE, DELETE, AND REJECT A MESSAGE 审中-公开
    使用运动手段发送,保存,删除和拒绝信息

    公开(公告)号:US20140125593A1

    公开(公告)日:2014-05-08

    申请号:US13670428

    申请日:2012-11-06

    申请人: Fang Li

    发明人: Fang Li

    IPC分类号: G06F3/033

    CPC分类号: G06F3/04883

    摘要: A method for providing a user interface includes creating a representative image of a media content, displaying the representative image on a screen, making the representative image a movable object on the screen, monitoring a motion gesture to move the representative image, and performing a corresponding action based on the motion gesture. The action includes saving, deleting, sending, or rejecting a message including the representative image and the media content or a link to the media content.

    摘要翻译: 提供用户界面的方法包括:创建媒体内容的代表图像,在屏幕上显示代表图像,使代表图像成为屏幕上的可移动对象,监视运动手势以移动代表图像,并执行相应的 基于动作姿态的动作。 该操作包括保存,删除,发送或拒绝包括代表图像和媒体内容的消息或到媒体内容的链接。

    Polariscope stress measurement tool and method of use
    7.
    发明授权
    Polariscope stress measurement tool and method of use 失效
    Polariscope应力测量工具及使用方法

    公开(公告)号:US08537342B2

    公开(公告)日:2013-09-17

    申请号:US13571481

    申请日:2012-08-10

    IPC分类号: G01B11/16 G01J4/00

    摘要: The present invention provides a tool for and method of using an infrared transmission technique to extract the full stress components of the in-plane residual stresses in thin, multi crystalline silicon wafers including in situ measurement of residual stress for large cast wafers. The shear difference method is used to obtain full stress components by integrating the shear stress map from the boundaries. System ambiguity at the boundaries is resolved completely by introducing a new analytical function. A new anisotropic stress optic law is provided, and stress optic coefficients are calibrated for different crystal grain orientations and stress orientations.

    摘要翻译: 本发明提供了一种使用红外透射技术提取薄多晶硅晶片中的平面内残余应力的全应力分量的工具和方法,包括原位测量大型晶圆的残余应力。 剪切差法用于通过从边界积分剪切应力图来获得全应力分量。 通过引入新的分析功能,完全解决了边界的系统模糊。 提供了新的各向异性应力光学定律,并且针对不同的晶粒取向和应力取向校准了应力光学系数。

    Uses of modified ELR-CXC chemokine G31P to treat cancer
    9.
    发明授权
    Uses of modified ELR-CXC chemokine G31P to treat cancer 有权
    使用改良的ELR-CXC趋化因子G31P治疗癌症

    公开(公告)号:US08299019B2

    公开(公告)日:2012-10-30

    申请号:US13048290

    申请日:2011-03-15

    IPC分类号: A61K38/00

    CPC分类号: A61K38/2053

    摘要: Described herein is the use of a modified human chemokine, GS-CXCL8(3-72)K11R/G31P or G31P in the treatment of a number of cancers, including but by no means limited to prostate cancer, liver cancer and melanoma.

    摘要翻译: 本文描述了修饰的人趋化因子GS-CXCL8(3-72)K11R / G31P或G31P在治疗许多癌症中的用途,包括但不限于前列腺癌,肝癌和黑素瘤。