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    System and method for acquiring breathing pattern signals from intracardiac electrograms and its use for heart failure therapy decision making and disease monitoring
    1.
    发明申请
    System and method for acquiring breathing pattern signals from intracardiac electrograms and its use for heart failure therapy decision making and disease monitoring 有权
    用于从心脏电图获取呼吸模式信号的系统和方法及其用于心力衰竭治疗决策和疾病监测

    公开(公告)号：US20050137487A1

    公开(公告)日：2005-06-23

    申请号：US10742683

    申请日：2003-12-19

    申请人： Qingsheng Zhu ,  John Hatlestad ,  Julio Spinelli ,  Ken Kenknight

    发明人： Qingsheng Zhu ,  John Hatlestad ,  Julio Spinelli ,  Ken Kenknight

    IPC分类号： A61B5/00 ,  A61B5/0402 ,  A61B5/0456 ,  A61B5/08

    CPC分类号： A61B5/0031 ,  A61B5/0456 ,  A61B5/0816

    摘要： An ICD processing system for acquiring breathing pattern signals from intracardiac electrograms obtained from implantable cardiac devices. The system may include both an implantable ICD device and an external processing system. Both the ICD module and the external processing system processing data to generate a representation for the respiration rate for a patient using intracardiac electrogram data obtained by the ICD device. The ICD module and the external processing module communicate with each other to pass collected patient data from the ICD module to the external processing system. The ICD module and the external processing module process the electrogram data to obtain an processed data representation of the respiration data which is used to estimate the respiration rate.

    摘要翻译： 一种ICD处理系统，用于从可植入心脏装置获得的心脏内电图获取呼吸模式信号。 该系统可以包括可植入ICD装置和外部处理系统。 ICD模块和外部处理系统两者都处理数据，以产生使用ICD设备获得的心内电描记图数据的患者呼吸率的表示。 ICD模块和外部处理模块相互通信，将收集的患者数据从ICD模块传递到外部处理系统。 ICD模块和外部处理模块处理电图数据以获得用于估计呼吸速率的呼吸数据的处理数据表示。

    System and method for acquiring breathing pattern signals from intracardiac electrograms and its use for heart failure therapy decision making and disease monitoring
    2.
    发明授权
    System and method for acquiring breathing pattern signals from intracardiac electrograms and its use for heart failure therapy decision making and disease monitoring 有权
    用于从心脏电图获取呼吸模式信号的系统和方法及其用于心力衰竭治疗决策和疾病监测

    公开(公告)号：US07184817B2

    公开(公告)日：2007-02-27

    申请号：US10742683

    申请日：2003-12-19

    申请人： Qingsheng Zhu ,  John Hatlestad ,  Julio Spinelli ,  Ken Kenknight

    发明人： Qingsheng Zhu ,  John Hatlestad ,  Julio Spinelli ,  Ken Kenknight

    IPC分类号： A61B5/402

    CPC分类号： A61B5/0031 ,  A61B5/0456 ,  A61B5/0816

    摘要： An ICD processing system for acquiring breathing pattern signals from intracardiac electrograms obtained from implantable cardiac devices. The system may include both an implantable ICD device and an external processing system. Both the ICD module and the external processing system processing data to generate a representation for the respiration rate for a patient using intracardiac electrogram data obtained by the ICD device. The ICD module and the external processing module communicate with each other to pass collected patient data from the ICD module to the external processing system. The ICD module and the external processing module process the electrogram data to obtain an processed data representation of the respiration data which is used to estimate the respiration rate.

    摘要翻译： 一种ICD处理系统，用于从可植入心脏装置获得的心脏内电图获取呼吸模式信号。 该系统可以包括可植入ICD装置和外部处理系统。 ICD模块和外部处理系统两者都处理数据，以产生使用ICD设备获得的心内电描记图数据的患者呼吸率的表示。 ICD模块和外部处理模块相互通信，将收集的患者数据从ICD模块传递到外部处理系统。 ICD模块和外部处理模块处理电图数据以获得用于估计呼吸速率的呼吸数据的处理数据表示。

    Implantable cardiac rhythm management system having multiple therapy modalities
    3.
    发明授权
    Implantable cardiac rhythm management system having multiple therapy modalities 有权
    具有多种治疗方式的植入式心律管理系统

    公开(公告)号：US07346393B2

    公开(公告)日：2008-03-18

    申请号：US10460975

    申请日：2003-06-12

    申请人： Julio Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

    发明人： Julio Spinelli ,  Qingsheng Zhu ,  Bruce H. Kenknight ,  Yinghong Yu ,  Jiang Ding

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3627

    摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.

    摘要翻译： 一种用于提供多种治疗方式的心律管理系统。 例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。 选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。 可以使用各种手动和自动方法来选择操作模式。 此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

    Method and device for preventing plaque formation in coronary arteries
    5.
    发明申请
    Method and device for preventing plaque formation in coronary arteries 失效
    用于预防冠状动脉斑块形成的方法和装置

    公开(公告)号：US20050283099A1

    公开(公告)日：2005-12-22

    申请号：US11203756

    申请日：2005-08-15

    申请人： Qingsheng Zhu ,  Avram Scheiner ,  Julio Spinelli

    发明人： Qingsheng Zhu ,  Avram Scheiner ,  Julio Spinelli

    IPC分类号： A61N1/05 ,  A61N1/32 ,  A61H1/02

    CPC分类号： A61N1/326 ,  A61N1/0587

    摘要： A method and device for preventing plaque build-up in a coronary artery includes providing an electrical field generating device, and generating an electrical field in the coronary artery to prevent plaque build-up in the coronary artery. The method further includes sensing the heart rhythm and generating the electrical field after a depolarization wave in the heart. The electrical field is generated by circuitry, in one embodiment implanted circuitry, connected to leads which are epicardially or intracardially positioned on the heart.

    摘要翻译： 用于防止冠状动脉斑块积聚的方法和装置包括提供电场产生装置，并且在冠状动脉中产生电场以防止冠状动脉中的斑块积聚。 该方法还包括感测心脏节律并在心脏中去极化波之后产生电场。 电场由电路产生，在一个实施例中，植入电路连接到心外膜或心内置于心脏上的引线。

    Maximum pacing rate limiter implemented using the evoked response—T-wave interval
    6.
    发明授权
    Maximum pacing rate limiter implemented using the evoked response—T-wave interval 失效
    使用诱发响应T波间隔实现最大起搏速率限制器

    公开(公告)号：US07953486B2

    公开(公告)日：2011-05-31

    申请号：US11225712

    申请日：2005-09-13

    申请人： Douglas R. Daum ,  Geng Zhang ,  Qingsheng Zhu ,  Gerrard M. Carlson ,  Julio Spinelli

    发明人： Douglas R. Daum ,  Geng Zhang ,  Qingsheng Zhu ,  Gerrard M. Carlson ,  Julio Spinelli

    IPC分类号： A61N1/365

    CPC分类号： A61N1/365

    摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.

    摘要翻译： 与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。 最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。 最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。 在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率 到起搏器。

    Core body temperature monitoring in heart failure patients
    7.
    发明授权
    Core body temperature monitoring in heart failure patients 有权
    核心体温监测心力衰竭患者

    公开(公告)号：US07479107B2

    公开(公告)日：2009-01-20

    申请号：US11258432

    申请日：2005-10-25

    申请人： Qingsheng Zhu ,  Julio Spinelli

    发明人： Qingsheng Zhu ,  Julio Spinelli

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14539 ,  A61B5/0008 ,  A61B5/024 ,  A61B5/076 ,  A61B5/145

    摘要： An implanted heart monitor includes sensors that measure various aspects of the heart failure patient's heart. A remote heart monitoring system connects the implanted heart monitor to a care provider, such as a physician. The data provided by the implanted heart monitor permits the care provider to obtain valuable data on the heart in order to make health care decisions affecting the heart failure patient's treatment. In many cases, the measurement of core body temperature and other patient data will enable the care provider to alter the patient's treatment to address the patient's condition. The implanted heart monitor can communicate over a wireless communication link with an external monitor. The implanted heart monitor may be implemented as part of a pacing device (i.e., pace maker) or may be a separate unit devoted to monitoring functions. The external monitor communicates with a monitoring station over a communication link. The monitoring station can operate as a centralized data collection unit, collecting data from multiple external monitors and multiple implanted heart monitors. Various other aspects of a heart failure patient's heart and/or body can be monitored, such as heart rate, blood pH levels, blood CO2 levels, and any other indications of the heart failure patient's activity. Various predetermined thresholds may be set to trigger alarms and/or data reports.

    摘要翻译： 植入心脏监测器包括测量心力衰竭患者心脏的各个方面的传感器。 远程心脏监测系统将植入的心脏监测器连接到护理提供者，例如医师。 由植入式心脏监测器提供的数据允许护理提供者在心脏上获得有价值的数据，以便使医疗保健决定影响心力衰竭患者的治疗。 在许多情况下，核心体温和其他患者数据的测量将使护理人员能够改变患者的治疗以解决病人的状况。 植入的心脏监测器可以通过无线通信链路与外部监视器进行通信。 植入心脏监视器可以被实现为起搏装置（即，起搏器）的一部分，或者可以是专用于监视功能的单独单元。 外部监视器通过通信链路与监控站进行通信。 监控站可以作为集中数据采集单元运行，从多个外部监视器和多个植入心脏监视器收集数据。 可以监测心力衰竭患者的心脏和/或身体的各种其他方面，例如心率，血液pH值，血液二氧化碳水平以及心力衰竭患者活动的任何其他指征。 可以设置各种预定阈值以触发报警和/或数据报告。

    System and method for remote expert-system medical device programming
    8.
    发明申请
    System and method for remote expert-system medical device programming 有权
    远程专家系统医疗设备编程的系统和方法

    公开(公告)号：US20080077031A1

    公开(公告)日：2008-03-27

    申请号：US11985995

    申请日：2007-11-19

    申请人： Julio Spinelli ,  Qingsheng Zhu

    发明人： Julio Spinelli ,  Qingsheng Zhu

    IPC分类号： A61B5/0452

    CPC分类号： A61N1/37282 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456 ,  G06Q50/22 ,  G16H40/40

    摘要： One embodiment includes a system for prescribing therapeutic treatment for a patient via communications over a network, including an implantable medical device (IMD) to be implanted in the patient to record a patient characteristic, the implantable medical device being programmable and configured to communicate via wireless communications with the IMD and to communicate securely over the network, the medical device programming computer including a user interface. The embodiment includes a server to communicate securely over the network with the medical device programming computer, the server including at least a first expert prescription system comprising at least one physician's prescription and at least one expert-system to compare the at least one patient characteristic to the at least one physician's prescription to issue a parameter to be programmed into the IMD based on the comparison.

    摘要翻译： 一个实施例包括一种用于通过网络进行通信来对患者进行治疗性治疗的系统，包括要植入患者中的可植入医疗装置（IMD）以记录患者特征，所述可植入医疗装置是可编程的并且经配置以经由无线 与IMD的通信并且通过网络安全地通信，医疗设备编程计算机包括用户界面。 该实施例包括通过网络与医疗设备编程计算机安全地通信的服务器，该服务器至少包括第一专家处方系统，该第一专家处方系统包括至少一个医师的处方和至少一个专家系统，以将至少一个患者特征与 所述至少一位医生处方根据比较发布要编程到IMD中的参数。

    Core body temperature monitoring in heart failure patients
    10.
    发明申请
    Core body temperature monitoring in heart failure patients 有权

    公开(公告)号：US20060047191A1

    公开(公告)日：2006-03-02

    申请号：US11258432

    申请日：2005-10-25

    申请人： Qingsheng Zhu ,  Julio Spinelli

    发明人： Qingsheng Zhu ,  Julio Spinelli

    IPC分类号： A61B5/05 ,  A61B5/02 ,  A61B5/00

    CPC分类号： A61B5/14539 ,  A61B5/0008 ,  A61B5/024 ,  A61B5/076 ,  A61B5/145

    摘要： An implanted heart monitor includes sensors that measure various aspects of the heart failure patient's heart. A remote heart monitoring system connects the implanted heart monitor to a care provider, such as a physician. The data provided by the implanted heart monitor permits the care provider to obtain valuable data on the heart in order to make health care decisions affecting the heart failure patient's treatment. In many cases, the measurement of core body temperature and other patient data will enable the care provider to alter the patient's treatment to address the patient's condition. The implanted heart monitor can communicate over a wireless communication link with an external monitor. The implanted heart monitor may be implemented as part of a pacing device (i.e., pace maker) or may be a separate unit devoted to monitoring functions. The external monitor communicates with a monitoring station over a communication link. The monitoring station can operate as a centralized data collection unit, collecting data from multiple external monitors and multiple implanted heart monitors. Various other aspects of a heart failure patient's heart and/or body can be monitored, such as heart rate, blood pH levels, blood CO2 levels, and any other indications of the heart failure patient's activity. Various predetermined thresholds may be set to trigger alarms and/or data reports.