公开(公告)号：US06529543B1

公开(公告)日：2003-03-04

申请号：US09717779

申请日：2000-11-21

申请人： R. Rox Anderson ,  Yacov Domankevitz

发明人： R. Rox Anderson ,  Yacov Domankevitz

IPC分类号： H01S308

CPC分类号： A61B18/203 ,  A61B2018/00452 ,  A61B2018/2277

摘要： The invention features systems and tools for controlling the optical penetration depth of laser energy, e.g., when delivering laser energy to target tissue in a patient. The systems and tools control the optical penetration depth (OPD) by controlling the incident angle at which the laser energy is delivered to the target area of the patient. Embodiments of the invention include an optical coupler that permit a user to vary the incident angle and thereby selectably control the OPD of incident laser energy. Fabricating the optical coupler to have a refractive index greater than that of the target tissue can enhance the range of selectable OPDs. The laser energy, which is delivered to the desired depth, can cause alteration of the target tissue by, e.g., heating, ablation, and/or photochemical reaction.

摘要翻译： 本发明的特征在于用于控制激光能量的光学穿透深度的系统和工具，例如当将激光能量传送到患者中的目标组织时。 系统和工具通过控制激光能量输送到患者的目标区域的入射角来控制光学穿透深度（OPD）。 本发明的实施例包括允许用户改变入射角并由此可选地控制入射激光能量的OPD的光耦合器。 制造光学耦合器以具有比目标组织的折射率更大的折射率可以增强可选OPD的范围。 输送到所需深度的激光能量可以通过例如加热，消融和/或光化学反应来引起靶组织的改变。

公开(公告)号：US6126655A

公开(公告)日：2000-10-03

申请号：US132878

申请日：1998-08-11

申请人： Yacov Domankevitz ,  R. Rox Anderson

发明人： Yacov Domankevitz ,  R. Rox Anderson

IPC分类号： A61B18/20 ,  A61B18/22 ,  A61B18/24 ,  A61B17/36

CPC分类号： A61B18/22 ,  A61B18/20 ,  A61B18/201 ,  A61B18/24 ,  A61B2018/2272

摘要： The invention features a probe for selectively delivering laser radiation to a first tissue having a first index of refraction relative to a second tissue having a second index of refraction less than the first index. The probe includes a laser transmitting medium having an optical axis and a tissue-contacting surface. In some embodiments, the optical axis contacts the tissue-contacting surface at an angle that is less than the critical angle for an interface between the tissue-contacting surface and the first tissue and greater than or equal to the critical angle for an interface between the tissue-contacting surface and the second tissue, wherein during operation the probe directs the laser radiation along the optical axis to the tissue-contacting surface. In other embodiments, the optical axis forms an angle with the tissue-contacting surface, and during operation the probe directs the laser radiation along the optical axis to the tissue-contacting surface, transmits a first amount of laser energy through the tissue-contacting surface when contacting the first tissue, and transmits a second amount of laser energy through the tissue-contacting surface when contacting the second tissue, wherein the angle is selected such that the first amount of laser energy is at least twice the second amount of laser energy. The invention also features related methods for selectively delivering laser radiation to tissue based on refractive index.

摘要翻译： 本发明的特征在于一种用于选择性地将激光辐射递送到具有相对于具有小于第一指数的第二折射率的第二组织的第一折射率的第一组织的探针。 探针包括具有光轴和组织接触表面的激光传输介质。 在一些实施例中，光轴以小于组织接触表面和第一组织之间的界面的临界角度的角度接触组织接触表面，并且大于或等于临界角之间的界面 组织接触表面和第二组织，其中在操作期间，探针将沿着光轴的激光辐射引导到组织接触表面。 在其它实施例中，光轴与组织接触表面形成一角度，并且在操作期间，探针将沿着光轴的激光辐射引导到组织接触表面，将第一量的激光能量透过组织接触表面 当接触所述第一组织时，并且当接触所述第二组织时，透射所述组织接触表面的第二量的激光能量，其中所述角度被选择为使得所述第一激光能量的量是所述第二激光能量的至少两倍。 本发明还涉及基于折射率选择性地将激光辐射递送到组织的相关方法。

公开(公告)号：US6129723A

公开(公告)日：2000-10-10

申请号：US563556

申请日：1995-11-28

申请人： R. Rox Anderson ,  Yacov Domankevitz

发明人： R. Rox Anderson ,  Yacov Domankevitz

IPC分类号： A61C1/00 ,  A61F9/01 ,  A61N5/06

CPC分类号： A61C1/0046 ,  A61F9/00804 ,  A61F2009/00872

摘要： An apparatus and method for superficially ablating and/or photochemically altering a substrate, e.g., a biological tissue, having a first refractive index, e.g., to a desired configuration, including a laser energy source which provides laser energy to an energy coupling wave generator which generates laser energy waves from the laser energy, the generator having a surface adapted to contact and form an interface with the substrate and having a second refractive index higher than the first refractive index, wherein laser energy entering the wave generator impinges on the surface at an angle of incidence greater than or equal to a critical angle for total internal reflection when the surface is not contacting the substrate, and wherein the wave generator couples the laser energy waves, e.g., refracted or evanescent waves, into the substrate at the interface to superficially ablate the substrate when contacting the substrate.

摘要翻译： 一种用于表面烧蚀和/或光化学改变具有第一折射率的基底（例如生物组织）的设备和方法，所述生物组织具有第一折射率，例如到期望的配置，包括向能量耦合波发生器提供激光能量的激光能量源， 从激光能量产生激光能量波，发生器具有适于接触并形成与衬底的界面并具有高于第一折射率的第二折射率的表面，其中进入波发生器的激光能量在 当表面不接触衬底时，入射角大于或等于全内反射的临界角，并且其中波发生器将表面上的界面处的激光能量波例如折射或ev逝波耦合到衬底中 在接触基底时烧蚀基底。

公开(公告)号：US06350261B1

公开(公告)日：2002-02-26

申请号：US09547299

申请日：2000-04-11

申请人： Yacov Domankevitz ,  R. Rox Anderson

发明人： Yacov Domankevitz ,  R. Rox Anderson

IPC分类号： A61B1818

CPC分类号： A61B18/22 ,  A61B18/20 ,  A61B18/201 ,  A61B18/24 ,  A61B2018/2272

摘要： The invention features methods and systems for selectively delivering or coupling laser radiation into a first material or substrate, e.g., a first biological tissue, having a first index of refraction and not into a second material or substrate, e.g., a second biological tissue, having a second index of refraction. The system determines whether a target area corresponds to the first material or the second material by monitoring the reflection of a probe beam incident on the target area through an optical coupler at a non-normal incident angle. The monitored reflection of the probe beam is a control signal for a feedback controller that causes a treatment beam to be delivered to the target area based on the monitored reflection.

摘要翻译： 本发明的特征在于用于选择性地将激光辐射输送或耦合到第一材料或基底（例如，具有第一折射率的第一生物组织）的方法和系统，而不是第二材料或基底，例如第二生物组织，其具有 第二折射率。 该系统通过以非正常入射角通过光耦合器监测入射在目标区域上的探测光束的反射来确定目标区域是否对应于第一材料或第二材料。 探测光束的监视反射是反馈控制器的控制信号，该反馈控制器基于所监视的反射将治疗光束输送到目标区域。

公开(公告)号：US07942153B2

公开(公告)日：2011-05-17

申请号：US11931232

申请日：2007-10-31

申请人： Dieter Manstein ,  R. Rox Anderson

发明人： Dieter Manstein ,  R. Rox Anderson

IPC分类号： A61B19/00

CPC分类号： A61B18/203 ,  A61B2018/00005 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/208

摘要： The present invention provides improved methods and apparatus for skin treatment. The apparatus includes multiple sources of optical energy or several blades that are scanned along a region of skin to form micro-line patterns of damaged tissue. The micro-lines are small in at least one dimension, having a width of less than about 1 mm, and the wounded regions promote beneficial results by stimulation of wound healing and tissue remodeling.

摘要翻译： 本发明提供了用于皮肤治疗的改进方法和装置。 该装置包括沿着皮肤区域扫描的多个光能源或几个叶片，以形成受损组织的微线图案。 微细线在至少一个维度上是小的，具有小于约1mm的宽度，受伤的区域通过刺激伤口愈合和组织重塑来促进有益的结果。

公开(公告)号：US06706032B2

公开(公告)日：2004-03-16

申请号：US09878155

申请日：2001-06-07

申请人： James C. Weaver ,  R. Rox Anderson ,  Terry O Herndon ,  T. R. Gowrishankar ,  Elizabeth A. Gift ,  Salvador Gonzalez

发明人： James C. Weaver ,  R. Rox Anderson ,  Terry O Herndon ,  T. R. Gowrishankar ,  Elizabeth A. Gift ,  Salvador Gonzalez

IPC分类号： A61M3100

CPC分类号： A61N1/325 ,  A61M5/427 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/044 ,  A61N1/30

摘要： The present invention relates to methods and devices used for the formation of microconduits in a tissue. The term “microconduit” refers to a small opening, channel, or hole into, or through, a tissue, that allows transfer of materials by liquid flow, and by electrophoresis, the microconduit being formed upon impact of a plurality of accelerated microparticles with the surface of the tissue. A method is described for forming at least one microconduit in tissue including the steps of: accelerating a plurality of microparticles to a velocity that causes the microparticles to penetrate a region of tissue surface upon impingement of the microparticles on the tissue surface; and directing the microparticle towards the region of tissue surface, thereby causing the microparticles to penetrate the tissue and form a microconduit in the tissue. According to an embodiment, microparticles are accelerated by being hit with a moving, solid surface. In another embodiment, microparticles are accelerated by a flowing gas or liquid. Also described are methods and devices for using microconduits to deliver therapeutic molecules and ions into tissue, or for extraction of chemical analytes out of tissue. Also described is a method of nail piercing to accommodate jewelry.

摘要翻译： 本发明涉及用于在组织中形成微管的方法和装置。 术语“微管道”是指通过液体流动允许材料转移并通过电泳的组织中的或通过组织的小的开口，通道或孔，在多个加速的微粒撞击时形成的微管， 组织表面。 描述了一种用于在组织中形成至少一个微管的方法，包括以下步骤：将多个微粒加速到使微粒在组织表面上碰撞时穿透组织表面区域的速度; 并将微粒引向组织表面的区域，从而使微粒穿透组织并在组织中形成微管。 根据一个实施例，通过用移动的固体表面击打微粒被加速。 在另一个实施方案中，微粒被流动的气体或液体加速。 还描述了使用微管道将治疗分子和离子递送到组织中或从组织中提取化学分析物的方法和装置。 还描述了一种钉子穿孔以适应首饰的方法。

公开(公告)号：US5879326A

公开(公告)日：1999-03-09

申请号：US845627

申请日：1997-04-25

申请人： Ned Allen Godshall ,  R. Rox Anderson

发明人： Ned Allen Godshall ,  R. Rox Anderson

IPC分类号： A61B17/00 ,  A61B17/20 ,  A61M35/00 ,  A61M37/00 ,  A61M31/00

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61M35/00 ,  A61B2017/00761 ,  A61M2037/0007 ,  A61M2037/0046 ,  A61M2037/0053

摘要： A method and apparatus for mechanically disrupting a layer of skin having a known thickness without substantially disrupting underlying dermis layers below the layer of skin in question so as to facilitate the delivery of compounds across the disrupted layer. The apparatus includes a cutter having a plurality of microprotrusions having a height chosen with respect to the layer of skin that is to be disrupted and a stop for preventing the apparatus from penetrating the skin beyond a predetermined distance. In the preferred embodiment of the present invention, the microprotrusions include blades that generate cuts in the layer of skin. The cuts are generated by moving the apparatus parallel to the surface of the skin either at the time of application, during the normal movements of the individual wearing the apparatus, or both. In the preferred embodiment of the present invention, the appropriate length of blade is determined for each individual and delivery site on that individual.

摘要翻译： 用于机械地破坏具有已知厚度的皮肤层的方法和装置，而不会基本上破坏所讨论的皮肤层下面的潜在的真皮层，以便促进化合物穿过破碎层。 该装置包括具有多个微突起的切割器，所述多个微突起具有相对于被破坏的皮肤层选择的高度，以及用于防止装置穿透皮肤超过预定距离的止挡件。 在本发明的优选实施例中，微突起物包括在皮肤层中产生切口的刀片。 切割是通过在施加时平行于皮肤表面移动装置，在佩戴装置的个体的正常运动期间或两者之间产生的。 在本发明的优选实施例中，为该个体上的每个个体和递送部位确定适当长度的叶片。

公开(公告)号：US5649923A

公开(公告)日：1997-07-22

申请号：US225259

申请日：1994-04-08

申请人： Kenton W. Gregory ,  R. Rox Anderson

发明人： Kenton W. Gregory ,  R. Rox Anderson

IPC分类号： A61B18/20 ,  A61B17/00 ,  A61B17/22 ,  A61B18/22 ,  A61B18/24 ,  A61B19/00 ,  A61D7/00 ,  A61F2/00 ,  G02B6/032 ,  A61B17/36

CPC分类号： G02B6/032 ,  A61B18/24 ,  A61B18/245 ,  A61B2017/00853 ,  A61B2017/22038 ,  A61B2017/22072 ,  A61B2018/206 ,  A61B2018/2261 ,  A61B2090/3933 ,  A61F2210/0019

摘要： A method for conducting laser energy to a site includes steps of bringing the proximal end of a flexible tube near the site, filling at least a proximal portion of the tube with a liquid by introducing the liquid into the tube, allowing a portion of the liquid to flow out from the proximal end of the tube toward the site, and directing laser energy from a laser energy source into the distal end of the tube, whereby a portion of the laser energy emerges from the proximal end of the tube at the site. Also, such a method in which the liquid is a radiographic contrast medium. Also, such a method for removing an obstruction from a blood vessel in an animal. Also, apparatus for delivering laser energy to a site includes a flexible tube, a liquid, the tube having an opening in a first end through which the liquid can pass, means for providing a flow of the liquid into the tube, and a source of laser energy operationally associated with a second end of the tube, wherein the tube and the liquid are adapted to cooperate, when the tube contains the liquid, to conduct laser energy from the source and to emit a portion of the laser energy from the first end of the liquid-containing tube.

摘要翻译： 用于向现场进行激光能量的方法包括以下步骤：使柔性管的近端靠近现场，通过将液体引入管中来填充液体的至少近端部分，允许液体的一部分 从管的近端向现场流出，并将来自激光能量源的激光能量引导到管的远端，由此一部分激光能量从位于管的近端处出现。 此外，这种液体是射线照相造影剂的方法。 此外，这种用于从动物的血管中除去阻塞物的方法。 而且，向场地传递激光能量的装置包括柔性管，液体，该管在第一端具有液体可以通过的开口，用于提供液体流入管的装置和 激光能量与管的第二端可操作地相关联，其中管和液体适于在管包含液体时协作以从源引入激光能量并从第一端发射一部分激光能量 的含液管。

公开(公告)号：US5556612A

公开(公告)日：1996-09-17

申请号：US213126

申请日：1994-03-15

申请人： R. Rox Anderson ,  Luciann Hruza ,  Nikiforos Kollias

发明人： R. Rox Anderson ,  Luciann Hruza ,  Nikiforos Kollias

IPC分类号： C07D487/22 ,  A61K8/00 ,  A61K8/35 ,  A61K8/49 ,  A61K31/047 ,  A61K31/12 ,  A61K31/185 ,  A61K31/195 ,  A61K31/35 ,  A61K31/352 ,  A61K31/44 ,  A61K31/443 ,  A61K31/60 ,  A61K41/00 ,  A61K45/00 ,  A61P17/00 ,  A61Q17/04 ,  A61Q19/04 ,  C07D311/16 ,  C07D405/04 ,  C07D493/04 ,  A61K7/40 ,  A61K7/42

CPC分类号： A61Q19/04 ,  A61K41/0066 ,  A61K8/35 ,  A61K8/498 ,  Y10S514/863

摘要： Method for treating a proliferative skin disorder, such as psoriasis, in a human patient having affected and non-affected areas of skin. The method comprises the steps of: (1) topically applying a sunscreen providing photo-protection to the affected and non-affected areas of skin; (2) waiting for a time period sufficient for the skin of the affected areas to be substantially sloughed off; and, (3) exposing the affected and non-affected areas of skin of the patient to a selected level of optical radiation. The level of radiation is chosen to be sufficient to treat the affected areas of skin and insufficient to cause significant damage to the non-affected areas of skin. The method enhances effectiveness and safety of treatment by providing preferential photo-protection to the non-affected skin areas, and may be used for phototherapy, photochemotherapy, or photodynamic therapy.

摘要翻译： 在患有受影响和未受影响的皮肤区域的人类患者中治疗增殖性皮肤病症如牛皮癣的方法。 该方法包括以下步骤：（1）向受影响和不受影响的皮肤区域局部施加提供光保护的防晒剂; （2）等待受影响地区皮肤充分剥离的时间; 和（3）将患者的受影响和不受影响的皮肤区域暴露于选定的光辐射水平。 选择辐射水平足以治疗受影响的皮肤区域，并且不足以对非受影响的皮肤区域造成显着损伤。 该方法通过向非受影响的皮肤区域提供优惠的光保护来提高治疗的有效性和安全性，并可用于光疗，光化疗或光动力疗法。

公开(公告)号：US20110137230A1

公开(公告)日：2011-06-09

申请号：US12967396

申请日：2010-12-14

申请人： Gregory B. Altshuler ,  Michael Smotrich ,  Henry H. Zenzie ,  Michael Z. Smirnov ,  R. Rox Anderson ,  Dieter Manstein ,  Eliot Battle

发明人： Gregory B. Altshuler ,  Michael Smotrich ,  Henry H. Zenzie ,  Michael Z. Smirnov ,  R. Rox Anderson ,  Dieter Manstein ,  Eliot Battle

IPC分类号： A61B18/20

CPC分类号： A61B18/203 ,  A61B2017/00172 ,  A61B2018/00452 ,  A61B2018/00476

摘要： A method and apparatus are provided for performing a medical procedure on a patient, for example a dermatological procedure, by use of electromagnetic radiation (EMR) having a relatively low peak power, and in particular a peak power low enough so as not to result in a phase change in the heater or chromophore absorbing radiation which would result in a significant reduction in its absorption, and of relatively long duration which is generally greater than, sometimes significantly greater than, the thermal relaxation time of the irradiated target.

摘要翻译： 提供了一种方法和装置，用于通过使用具有相对低的峰值功率的电磁辐射（EMR），特别是足够低的峰值功率来对患者执行医疗程序，例如皮肤病学程序，以便不会导致 吸收辐射的加热器或发色团的相变将导致其吸收的显着降低，并且相对长的持续时间通常大于有时显着大于照射的靶的热松弛时间。