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公开(公告)号：US20160010136A1
公开(公告)日：2016-01-14
申请号：US14773059
申请日：2014-03-13
发明人： Roger A. Nassar
CPC分类号： C12Q1/04 , B82Y15/00 , G01N21/78 , G01N33/54313 , Y02A50/53 , Y02A50/58 , Y02A50/59 , Y02A50/60
摘要： Methods of detecting biologicals in samples is provided herein. The detection is based on the formation of aggregates. The disclosed compositions include labeling particles and/or aggregating particles. The labeling particles and the aggregating particles may each include a receptor bound to the particle. The receptor can be either directly attached to the particle or indirectly attached to the particle through a linker. One method of detection may be visual and another may include advanced quantification of the formed aggregates.
摘要翻译： 本文提供了检测样品中生物体的方法。 检测是基于聚集体的形成。 所公开的组合物包括标记颗粒和/或聚集颗粒。 标记颗粒和聚集颗粒可以各自包括与颗粒结合的受体。 受体可以直接连接到颗粒上，或者通过连接体间接连接到颗粒上。 一种检测方法可以是视觉的，另一种可以包括形成的聚集体的高级定量。
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公开(公告)号：US11505648B2
公开(公告)日：2022-11-22
申请号：US15567232
申请日：2016-04-20
发明人： Roger A. Nassar
IPC分类号： C08G65/334 , C08G65/00 , C08G65/332 , C08G65/337 , C08G65/329 , C08G65/333
摘要： The present disclosure provides amphiphilic fluorinated surfactant molecules for lowering the surface tension of aqueous, hydrocarbon, or solid phases in the presence of a fluorophilic continuous phase and for selectively interacting with biological and/or chemical molecules.
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公开(公告)号：US11578351B2
公开(公告)日：2023-02-14
申请号：US16846509
申请日：2020-04-13
发明人： Roger A. Nassar
IPC分类号： C12Q1/04 , G01N21/78 , G01N33/543 , B82Y15/00
摘要： Methods of detecting biologicals in samples is provided herein. The detection is based on the formation of aggregates. The disclosed compositions include labeling particles and/or aggregating particles. The labeling particles and the aggregating particles may each include a receptor bound to the particle. The receptor can be either directly attached to the particle or indirectly attached to the particle through a linker. One method of detection may be visual and another may include advanced quantification of the formed aggregates.
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公开(公告)号：US20220135962A1
公开(公告)日：2022-05-05
申请号：US17435345
申请日：2020-04-17
发明人： Roger A. Nassar , Robert E. Lintner
IPC分类号： C12N11/04 , C12N11/087
摘要： The present invention is directed to synthesizing and using fluid-insoluble material complexes that capture biologicals and remove them from samples in microscopic scale fluids, such as in droplets, wells, and micro-wells. The present invention also pertains to the option of detecting the captured biologicals, to the option of modifying the captured biologicals, and to the option of controllably releasing the captured biologicals.
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公开(公告)号：US10105681B2
公开(公告)日：2018-10-23
申请号：US14773024
申请日：2014-03-13
发明人： Roger A. Nassar
IPC分类号： C07K1/22 , C12N7/02 , B01J20/24 , C12N11/10 , A61M1/36 , C12N11/02 , C12N11/06 , C12N11/08 , C12N11/14 , B01J20/26 , C12N7/00 , C02F3/10
摘要： Material complexes that capture biologicals and methods of synthesizing and using such complexes composed of fluid-insoluble material and a receptor are provided herewith. The fluid-insoluble material has reactive functionality on its surface, including hydroxyl, amino, mercapto or epoxy functionality material. The material can be agarose, sand, textile, or any combination thereof. The receptor is selected from the group consisting of mono- and poly-saccharides, heparin, or any combination thereof. Also provided are methods whereby releasing the captured biologicals is controllable.
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公开(公告)号：US20180112036A1
公开(公告)日：2018-04-26
申请号：US15567232
申请日：2016-04-20
发明人： Roger A. Nassar
IPC分类号： C08G65/334 , C08G65/333 , C08G65/329 , C08G65/332
CPC分类号： C08G65/3348 , C08G65/007 , C08G65/329 , C08G65/3322 , C08G65/3328 , C08G65/33303 , C08G65/33317 , C08G65/337
摘要： The present disclosure provides amphiphilic fluorinated surfactant molecules for lowering the surface tension of aqueous, hydrocarbon, or solid phases in the presence of a fluorophilic continuous phase and for selectively interacting with biological and/or chemical molecules.
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公开(公告)号：US20170361324A1
公开(公告)日：2017-12-21
申请号：US15628513
申请日：2017-06-20
IPC分类号： B01L9/00 , G01N35/00 , G01N1/28 , G01N33/483
CPC分类号： B01L9/00 , B01L2300/02 , G01N1/28 , G01N33/483 , G01N35/00722 , G02B21/16 , G02B21/28 , G02B21/30 , G02B21/34 , H04N5/2252
摘要： A viewer device for observing and recording images of materials, such as chemical and biological materials is described. The viewer device includes a housing that provides a chamber for receiving a sample or a sample container that contains a sample of a material (e.g., chemical or biological material). The housing includes a viewing window for observing the sample, a port through which the sample or the sample container can be introduced to or removed from the chamber, and a coupling mechanism configured to removably and replaceably couple the housing to an observational device, such as a camera equipped device.
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公开(公告)号：US20230356168A1
公开(公告)日：2023-11-09
申请号：US17786441
申请日：2020-12-18
发明人： Robert E. Lintner , Roger A. Nassar
CPC分类号： B01J13/0052 , B01J13/14 , C08J3/03 , C08J3/241 , C08J3/096 , C08J2300/106
摘要： The present invention is generally directed to beads, methods of making said beads, and methods of functionalizing said beads with one or more functional groups to form functionalized beads, such as universal functionalized beads, wherein the functional group can be a chemical group. In some embodiments, the beads can be gel beads.
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公开(公告)号：US11123708B2
公开(公告)日：2021-09-21
申请号：US16130785
申请日：2018-09-13
发明人： Roger A. Nassar
IPC分类号： B01J20/24 , C12N7/00 , C12N11/10 , A61M1/36 , C07K1/22 , C12N11/02 , C12N11/06 , C12N11/08 , C12N11/14 , B01J20/26 , C02F3/10
摘要： Material complexes that capture biologicals and methods of synthesizing and using such complexes composed of fluid-insoluble material and a receptor are provided herewith. The fluid-insoluble material has reactive functionality on its surface, including hydroxyl, amino, mercapto or eposy functionality material. The material can be agarose, sand, textile, or any combination thereof. The receptor is selected from the group consisting of mono-and poly-saccharides, heparin, or any combination thereof. Also provide are methods whereby releasing the captured biologicals and is controllable.
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公开(公告)号：US20200239929A1
公开(公告)日：2020-07-30
申请号：US16846509
申请日：2020-04-13
发明人： Roger A. Nassar
IPC分类号： C12Q1/04 , G01N33/543 , G01N21/78
摘要： Methods of detecting biologicals in samples is provided herein. The detection is based on the formation of aggregates. The disclosed compositions include labeling particles and/or aggregating particles. The labeling particles and the aggregating particles may each include a receptor bound to the particle. The receptor can be either directly attached to the particle or indirectly attached to the particle through a linker. One method of detection may be visual and another may include advanced quantification of the formed aggregates.
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