公开(公告)号：US10676763B2

公开(公告)日：2020-06-09

申请号：US15326844

申请日：2015-07-17

申请人： REG Life Sciences, LLC

发明人： Andreas W. Schirmer ,  Noah Helman ,  Haibo Wang ,  Zhihao Hu ,  Vikranth Arlagadda ,  Alma Itzel Ramos-Solis ,  Elizabeth Clarke

IPC分类号： C12P7/18 ,  C12N9/16 ,  C12N9/00 ,  C12N15/52 ,  C12N9/18 ,  C12N9/02 ,  C12N9/04 ,  C12N15/63

摘要： The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.

公开(公告)号：US20180010137A1

公开(公告)日：2018-01-11

申请号：US15650285

申请日：2017-07-14

申请人： REG Life Sciences, LLC

发明人： Derek L. GREENFIELD ,  Andreas W. Schirmer ,  Elizabeth J. CLARKE ,  Eli S. GROBAN ,  Bernardo M. Da Costa ,  Zhihao Hu ,  Kevin Holden ,  Noah Helman

IPC分类号： C12N15/70 ,  C12P7/64 ,  C12P7/04 ,  C12N9/02 ,  C12N9/90 ,  C12N9/88 ,  C12N9/12 ,  C12N9/10 ,  C12N9/04 ,  C12N9/00

CPC分类号： C12N15/70 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1288 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12P7/04 ,  C12P7/6409 ,  C12P7/6436 ,  C12Y101/011 ,  C12Y103/01009 ,  C12Y103/0101 ,  C12Y203/01039 ,  C12Y203/01041 ,  C12Y203/01179 ,  C12Y203/0118 ,  C12Y207/08007 ,  C12Y402/01059 ,  C12Y503/03014 ,  C12Y604/01002

摘要： The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.

公开(公告)号：US09879239B2

公开(公告)日：2018-01-30

申请号：US14424387

申请日：2013-03-15

申请人： REG Life Sciences, LLC.

发明人： Andrew M. Shumaker ,  Bernardo M. Da Costa ,  Kevin Holden ,  Louis G. Hom ,  Tarah S. Baron ,  Noah Helman

IPC分类号： C12N9/18 ,  C12N9/10 ,  C12P7/64

CPC分类号： C12N9/18 ,  C12N9/1007 ,  C12P7/6436 ,  C12Y201/01015

摘要： The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.