公开(公告)号：US20150064782A1

公开(公告)日：2015-03-05

申请号：US14390378

申请日：2013-04-02

申请人： LS9, INC.

发明人： Derek L. Greenfield ,  Andreas W. Schirmer ,  Elizabeth J. Clarke ,  Eli S. Groban ,  Bernardo M. Da Costa ,  Zhihao Hu

IPC分类号： C12N15/70 ,  C12P7/64

CPC分类号： C12N15/70 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1288 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12P7/04 ,  C12P7/6409 ,  C12P7/6436 ,  C12Y101/011 ,  C12Y103/01009 ,  C12Y103/0101 ,  C12Y203/01039 ,  C12Y203/01041 ,  C12Y203/01179 ,  C12Y203/0118 ,  C12Y207/08007 ,  C12Y402/01059 ,  C12Y503/03014 ,  C12Y604/01002

摘要： The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.

摘要翻译： 本发明涉及组合物和方法，包括多核苷酸序列，氨基酸序列，重组宿主细胞和重组宿主细胞培养物，其工程改造以产生脂肪酸衍生物组合物，其包含脂肪酸，脂肪醇，脂肪醛，脂肪酸酯，烷烃，末端烯烃，内部 烯烃或酮。 脂肪酸衍生物组合物在细胞外产生比相应的野生型或非工程化宿主细胞更高的滴度，产量或生产力。

公开(公告)号：US20180010137A1

公开(公告)日：2018-01-11

申请号：US15650285

申请日：2017-07-14

申请人： REG Life Sciences, LLC

发明人： Derek L. GREENFIELD ,  Andreas W. Schirmer ,  Elizabeth J. CLARKE ,  Eli S. GROBAN ,  Bernardo M. Da Costa ,  Zhihao Hu ,  Kevin Holden ,  Noah Helman

IPC分类号： C12N15/70 ,  C12P7/64 ,  C12P7/04 ,  C12N9/02 ,  C12N9/90 ,  C12N9/88 ,  C12N9/12 ,  C12N9/10 ,  C12N9/04 ,  C12N9/00

CPC分类号： C12N15/70 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1288 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12P7/04 ,  C12P7/6409 ,  C12P7/6436 ,  C12Y101/011 ,  C12Y103/01009 ,  C12Y103/0101 ,  C12Y203/01039 ,  C12Y203/01041 ,  C12Y203/01179 ,  C12Y203/0118 ,  C12Y207/08007 ,  C12Y402/01059 ,  C12Y503/03014 ,  C12Y604/01002

摘要： The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.

公开(公告)号：US20240150774A1

公开(公告)日：2024-05-09

申请号：US18344219

申请日：2023-06-29

申请人： Genomatica, Inc.

发明人： Derek L. GREENFIELD ,  Andreas W. Schirmer ,  Elizabeth J. Clarke ,  Eli S. Groban ,  Bernardo M. Da Costa ,  Zhihao Hu ,  Kevin Holden ,  Noah Helman

IPC分类号： C12N15/70 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90 ,  C12P7/04 ,  C12P7/6409 ,  C12P7/6436

CPC分类号： C12N15/70 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1288 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12P7/04 ,  C12P7/6409 ,  C12P7/6436 ,  C12Y101/011 ,  C12Y103/01009 ,  C12Y103/0101 ,  C12Y203/01039 ,  C12Y203/01041 ,  C12Y203/01179 ,  C12Y203/0118 ,  C12Y207/08007 ,  C12Y402/01059 ,  C12Y503/03014 ,  C12Y604/01002

摘要： The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.