公开(公告)号：US20240290841A1

公开(公告)日：2024-08-29

申请号：US18581565

申请日：2024-02-20

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven Koester

IPC: H01L29/16 ,  A61B5/08 ,  A61L31/02 ,  C01B32/194 ,  G01N27/04 ,  G01N27/22 ,  G01N33/497 ,  H01L21/02 ,  H01L29/93

CPC classification number: H01L29/1606 ,  A61B5/082 ,  A61L31/024 ,  C01B32/194 ,  G01N27/045 ,  G01N27/228 ,  G01N33/497 ,  H01L29/93 ,  C01B2204/22 ,  G01N2027/222 ,  H01L21/02499 ,  H01L2229/00

Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included having a graphene varactor including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through non-covalent interactions between the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer includes one or more pillarenes, substituted pillarenes, calixarenes, substituted calixarenes, peralkylated cyclodextrins, substituted peralkylated cyclodextrins, pyrenes, or substituted pyrenes, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20190331661A1

公开(公告)日：2019-10-31

申请号：US16393177

申请日：2019-04-24

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester ,  Justin Theodore Nelson

IPC: G01N33/497 ,  G01N27/22 ,  G01N27/12

Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a it-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20220291198A1

公开(公告)日：2022-09-15

申请号：US17707214

申请日：2022-03-29

Applicant: Boston Scientific Scimed, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester ,  Justin Theodore Nelson

IPC: G01N33/497 ,  G01N27/12 ,  G01N27/22

Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20220334075A1

公开(公告)日：2022-10-20

申请号：US17719760

申请日：2022-04-13

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Steven Koester ,  Qun Su ,  Philippe Pierre Joseph Buhlmann ,  Xue Zhen ,  Justin Theodore Nelson ,  Gregory J. Sherwood

IPC: G01N27/22 ,  G01N33/497

Abstract: Embodiments herein relate to systems and methods for utilizing hysteresis as a mechanism of analysis of a sample. A system for analyzing a fluid sample is included having a controller circuit and a chemical sensor element. The chemical sensor element can include one or more discrete binding detectors that can include one or more graphene varactors. The system can include measurement circuitry having an electrical voltage generator configured to generate an applied voltage at a plurality of voltage values to be applied to the one or more graphene varactors. The system can include a measurement circuit having a capacitance sensor configured to measure capacitance of the discrete binding detectors resulting from the applied voltage. The system for analyzing the fluid sample can be configured to measure hysteresis effects related to capacitance versus voltage values obtained from the one or more graphene varactors. Other embodiments are also included herein.

公开(公告)号：US20220304589A1

公开(公告)日：2022-09-29

申请号：US17689760

申请日：2022-03-08

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Blair K. Troudt ,  Philippe Pierre Joseph Buhlmann ,  Steven Koester ,  Xue Zhen

IPC: A61B5/08 ,  C01B32/194 ,  B05D1/00 ,  A61B5/05 ,  G01N27/22

Abstract: Embodiments herein relate to chemical sensors based on the non-covalent surface modification of graphene with compounds containing hydrazine or hydroxylamine functional groups for the detection of aldehyde and ketone-bearing analytes. In an embodiment, a medical device is included having a graphene varactor included a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer can include one or more compounds having one or more hydrazine groups or hydroxylamine groups, substituted hydrazine or hydroxylamine groups, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20210369250A1

公开(公告)日：2021-12-02

申请号：US17328478

申请日：2021-05-24

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Philippe Pierre Joseph Buhlmann ,  Steven J. Koester ,  Justin Theodore Nelson ,  Xue Zhen

IPC: A61B10/00 ,  C01B32/194 ,  C01G7/00

Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included having a graphene varactor. The graphene varactor includes a graphene layer and at least one non-covalent modification layer disposed on an outer surface of the graphene layer. The non-covalent modification layer can include nanoparticles selected from a group that can include one or more metals, metal oxides, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20210147238A1

公开(公告)日：2021-05-20

申请号：US17096104

申请日：2020-11-12

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Steven J. Koester ,  Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Qun Su ,  Justin Theodore Nelson ,  Gregory J. Sherwood

IPC: C01B32/19 ,  C09D5/00 ,  C09D9/00 ,  C09D127/12 ,  G01N33/00 ,  G01N27/22

Abstract: Embodiments herein relate to methods and systems for applying a transfer material layer to graphene during a graphene fabrication process. In an embodiment, a method of producing a graphene sensor element is included. The method includes forming a graphene layer on a growth substrate and applying a fluoropolymer coating layer over the graphene layer. The method includes removing the growth substrate and transferring the graphene and fluoropolymer coating layers onto a transfer substrate, where the graphene layer is disposed on the transfer substrate and the fluoropolymer layer is disposed on the graphene layer. The method also includes removing the fluoropolymer coating layer. Other embodiments are also included herein.

公开(公告)号：US20200337566A1

公开(公告)日：2020-10-29

申请号：US16860529

申请日：2020-04-28

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Gregory Kermit Peterson ,  Elizabeth Rose Lusczek ,  Gregory Joseph Beilman ,  Kristine Elizabeth Mulier ,  Philippe Pierre Joseph Buhlmann

IPC: A61B5/02 ,  A61B5/0205 ,  A61B5/08 ,  A61B5/145 ,  A61B5/20 ,  A61B5/00 ,  G01N33/497 ,  G01N33/50

Abstract: Embodiments herein relate to systems, devices, and methods for assessing hemorrhage and other conditions and treating patients suffering from the same. In an embodiment, a method for detecting hemorrhage in a patient is included. The method can include obtaining a breath sample from the subject and contacting it with a chemical sensor element, the chemical sensor element including a plurality of discrete graphene varactors; sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set; and classifying the sample data set into one or more preestablished hemorrhage classifications. Other embodiments are included herein.

公开(公告)号：US20190257825A1

公开(公告)日：2019-08-22

申请号：US16280635

申请日：2019-02-20

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Xue V. Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester ,  Yao Zhang ,  Justin Theodore Nelson

IPC: G01N33/53

Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.

公开(公告)号：US11923419B2

公开(公告)日：2024-03-05

申请号：US16996537

申请日：2020-08-18

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester

IPC: H01L29/16 ,  A61B5/08 ,  A61L31/02 ,  C01B32/194 ,  G01N27/04 ,  G01N27/22 ,  G01N33/497 ,  H01L29/93 ,  H01L21/02

CPC classification number: H01L29/1606 ,  A61B5/082 ,  A61L31/024 ,  C01B32/194 ,  G01N27/045 ,  G01N27/228 ,  G01N33/497 ,  H01L29/93 ,  C01B2204/22 ,  G01N2027/222 ,  H01L21/02499 ,  H01L2229/00

Abstract: Chemical sensors, devices and systems including the same, and related methods are disclosed. In an embodiment, a medical device is included having a graphene varactor including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through non-covalent interactions between the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer includes one or more pillarenes, substituted pillarenes, calixarenes, substituted calixarenes, peralkylated cyclodextrins, substituted peralkylated cyclodextrins, pyrenes, or substituted pyrenes, or derivatives of each. Other embodiments are also included.