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公开(公告)号：US11642374B2
公开(公告)日：2023-05-09
申请号：US16182146
申请日：2018-11-06
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61P35/00 , A61K35/17 , A61K48/00 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96 , C12N15/87
CPC分类号： A61K35/17 , C07K14/4718 , C07K14/7051 , C07K14/70503 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/907 , C12N15/87 , C12N2310/20 , C12N2510/00
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US11147837B2
公开(公告)日：2021-10-19
申请号：US15256086
申请日：2016-09-02
申请人： Regents of the University of Minnesota , Intima Bioscience, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , R. Scott McIvor , David Largaespada , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61K35/17 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96 , C12N15/87
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US10166255B2
公开(公告)日：2019-01-01
申请号：US15224151
申请日：2016-07-29
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , R. Scott McIvor , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： C12N5/10 , C12N15/90 , A61K35/17 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C07K14/715 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/87
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US20220125843A1
公开(公告)日：2022-04-28
申请号：US17478615
申请日：2021-09-17
申请人： Regents of the University of Minnesota , Intima Bioscience, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , R. Scott McIvor , David Largaespada , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61K35/17 , C07K14/47 , C12N9/22 , C12N9/96 , C07K14/725 , C12N15/90 , C07K14/715 , C12N15/113 , C07K14/705 , C12N5/0783 , C12N15/87
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US11642375B2
公开(公告)日：2023-05-09
申请号：US16182189
申请日：2018-11-06
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61P35/00 , A61K35/17 , A61K48/00 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96 , C12N15/87
CPC分类号： A61K35/17 , C07K14/4718 , C07K14/7051 , C07K14/70503 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/907 , C12N15/87 , C12N2310/20 , C12N2510/00
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US10912797B2
公开(公告)日：2021-02-09
申请号：US15947688
申请日：2018-04-06
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as Represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61K35/17 , C12N15/113 , C07K14/705 , C07K14/47 , A61P31/00 , A61P35/00 , A61K9/00 , C07K14/725 , C07K14/715 , C12N5/0783 , C12N9/22 , C12N15/79 , C12N15/90 , A61K45/06
摘要： Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
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公开(公告)号：US10406177B2
公开(公告)日：2019-09-10
申请号：US15250514
申请日：2016-08-29
申请人： Regents of the University of Minnesota , Intima Bioscience, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： C12N5/00 , C12N15/90 , A61K35/17 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C07K14/715 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/87
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US20190054122A1
公开(公告)日：2019-02-21
申请号：US16180867
申请日：2018-11-05
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as represented by the Secretary, Department of Health and Human
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61K35/17 , C12N15/90 , C07K14/47 , C07K14/705 , C07K14/725 , C12N9/96 , C12N9/22 , C12N5/0783 , C07K14/715 , C12N15/113 , C12N15/87
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US20220105133A1
公开(公告)日：2022-04-07
申请号：US17481404
申请日：2021-09-22
申请人： Regents of the University of Minnesota , Intima Bioscience, Inc. , The U.S.A., as Represented by the Secretary, Department of Health and Human Service
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61K35/17 , C12N15/113 , C07K14/705 , C07K14/47 , A61P31/00 , A61P35/00 , A61K9/00 , C07K14/725 , C07K14/715 , C12N5/0783 , C12N9/22 , C12N15/79 , C12N15/90
摘要： Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
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公开(公告)号：US11925664B2
公开(公告)日：2024-03-12
申请号：US16900368
申请日：2020-06-12
申请人： Regents of the University of Minnesota , Intima Bioscience, Inc. , The U.S.A., as Represented by the Secretary, Department of Health and Human Services
IPC分类号： A61K48/00 , A61K35/17 , C07K14/47 , C07K14/705 , C07K14/715 , C07K14/725 , C12N5/0783 , C12N9/22 , C12N9/96 , C12N15/07 , C12N15/113 , C12N15/90 , C12N15/87
CPC分类号： A61K35/17 , C07K14/4718 , C07K14/70503 , C07K14/7051 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/907 , C12N15/87 , C12N2310/20 , C12N2510/00
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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