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公开(公告)号：US11642374B2
公开(公告)日：2023-05-09
申请号：US16182146
申请日：2018-11-06
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61P35/00 , A61K35/17 , A61K48/00 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96 , C12N15/87
CPC分类号： A61K35/17 , C07K14/4718 , C07K14/7051 , C07K14/70503 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/907 , C12N15/87 , C12N2310/20 , C12N2510/00
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US11147837B2
公开(公告)日：2021-10-19
申请号：US15256086
申请日：2016-09-02
申请人： Regents of the University of Minnesota , Intima Bioscience, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , R. Scott McIvor , David Largaespada , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61K35/17 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96 , C12N15/87
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US10166255B2
公开(公告)日：2019-01-01
申请号：US15224151
申请日：2016-07-29
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , R. Scott McIvor , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： C12N5/10 , C12N15/90 , A61K35/17 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C07K14/715 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/87
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US11642375B2
公开(公告)日：2023-05-09
申请号：US16182189
申请日：2018-11-06
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61P35/00 , A61K35/17 , A61K48/00 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96 , C12N15/87
CPC分类号： A61K35/17 , C07K14/4718 , C07K14/7051 , C07K14/70503 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/907 , C12N15/87 , C12N2310/20 , C12N2510/00
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US10912797B2
公开(公告)日：2021-02-09
申请号：US15947688
申请日：2018-04-06
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as Represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： A61K35/17 , C12N15/113 , C07K14/705 , C07K14/47 , A61P31/00 , A61P35/00 , A61K9/00 , C07K14/725 , C07K14/715 , C12N5/0783 , C12N9/22 , C12N15/79 , C12N15/90 , A61K45/06
摘要： Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
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公开(公告)号：US10406177B2
公开(公告)日：2019-09-10
申请号：US15250514
申请日：2016-08-29
申请人： Regents of the University of Minnesota , Intima Bioscience, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号： C12N5/00 , C12N15/90 , A61K35/17 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C07K14/715 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/87
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US11111478B2
公开(公告)日：2021-09-07
申请号：US16410327
申请日：2019-05-13
IPC分类号： C12N15/85 , C12N5/0783 , A61K35/17 , A61K39/00
摘要： Provided are methods of producing an isolated T memory stem cell population, the method comprising a) isolating naïve T cells from a mammal, wherein the mammal is not a mouse; b) activating the naïve T cells and expanding the numbers of naïve T cells in the presence of one or more non-specific T cell stimuli, one or more cytokines, and a GSK-3beta inhibitor. Also provided are methods of producing an isolated T memory stem cell population, the method comprising a) isolating lymphocytes from a mammal; b) sorting the lymphocytes using flow cytometry into a population comprising a phenotype comprising i) CD95+, CD45RO−, and CCR7+; and ii) CD62L+ or one or more of CD27+, CD28+, CD45RA+, and CD127+ to produce an isolated T memory stem cell population. Further embodiments of the invention provide related cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.
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公开(公告)号：US20200263136A1
公开(公告)日：2020-08-20
申请号：US16762447
申请日：2018-11-08
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
IPC分类号： C12N5/0789 , A61K35/28
摘要： Disclosed are methods of preparing CD34+CD43+ hematopoietic progenitor cells (HPC) in vitro according to embodiments of the invention. Also disclosed are methods of differentiating CD34+CD43+ hematopoietic progenitor cells to hematopoietic lineage cells according to embodiments of the invention. Also disclosed are methods of treating or preventing a condition in a mammal, e.g., cancer, according to embodiments of the invention.
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公开(公告)号：US11898166B2
公开(公告)日：2024-02-13
申请号：US16648008
申请日：2018-09-19
CPC分类号： C12N5/065 , A61K35/26 , C12N2500/98 , C12N2501/105 , C12N2501/117 , C12N2501/15 , C12N2501/41 , C12N2501/415 , C12N2506/45 , C12N2513/00
摘要： Disclosed are methods of preparing thymic organoids according to embodiments of the invention. Also disclosed are methods of preparing thymic emigrant cells in vitro, according to embodiments of the invention. Also disclosed are methods of treating or preventing a condition in a mammal, e g., cancer.
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公开(公告)号：US20210395683A1
公开(公告)日：2021-12-23
申请号：US17465577
申请日：2021-09-02
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
IPC分类号： C12N5/0783 , A61K35/17
摘要： Provided are methods of producing an isolated T memory stem cell population, the method comprising a) isolating naïve T cells from a mammal, wherein the mammal is not a mouse; b) activating the naïve T cells and expanding the numbers of naïve T cells in the presence of one or more non-specific T cell stimuli, one or more cytokines, and a GSK-3beta inhibitor. Also provided are methods of producing an isolated T memory stem cell population, the method comprising a) isolating lymphocytes from a mammal; b) sorting the lymphocytes using flow cytometry into a population comprising a phenotype comprising i) CD95+, CD45RO−, and CCR7+; and ii) CD62L+ or one or more of CD27+, CD28+, CD45RA+, and CD127+ to produce an isolated T memory stem cell population. Further embodiments of the invention provide related cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.
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