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公开(公告)号：US20230338872A1
公开(公告)日：2023-10-26
申请号：US18218143
申请日：2023-07-05
Applicant: Repligen Corporation
Inventor： James Ronald Peyser , Dana Cristina Pentia
CPC classification number: B01D15/206 , A61L2/081 , A61L2/087 , B01D15/20 , B01D15/3809
Abstract: If one sterilizes pre-packed, plastic chromatography columns with an appropriate level of gamma irradiation, the resulting sterile chromatography columns maintain sufficient packing media function and maintain column mechanical properties and pressure ratings.
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公开(公告)号：US11938417B2
公开(公告)日：2024-03-26
申请号：US17836412
申请日：2022-06-09
Applicant: Repligen Corporation
Inventor： Alan Kit Ho Chan , James Ronald Peyser
IPC: B01D15/10 , A61L2/08 , B01D15/20 , B01D15/36 , B01J39/04 , B01J39/19 , B01J39/26 , G01N30/50 , G01N30/60
CPC classification number: B01D15/10 , B01D15/20 , B01D15/362 , B01J39/04 , B01J39/19 , B01J39/26 , G01N30/50 , G01N30/6034 , A61L2/081
Abstract: Methods and systems for removing gases and/or pressure formed during the sterilization, e.g., the gamma irradiation, of prepacked chromatography systems (column plus attached tube and valve set) are described. The methods include purging the gas and/or pressure through specially designed tube and valve sets without breaching the sterility of the prepacked sterile chromatography system. The systems include a sterile or aseptic pre-packed chromatography column including a column having an inlet and an outlet, a tubing and valve set attached to the inlet and the outlet, and a pump configured to pump sterile or aseptic liquid from the fluid source along the tubing and valve set, into the column tube inlet and out of the column tube outlet along a first flow path, thereby removing any entrapped gas and/or pressure from the chamber.
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公开(公告)号：US20180154280A1
公开(公告)日：2018-06-07
申请号：US15890144
申请日：2018-02-06
Applicant: Repligen Corporation
Inventor： James Ronald Peyser , Dana Cristina Pentia
Abstract: If one sterilizes pre-packed, plastic chromatography columns with an appropriate level of gamma irradiation, the resulting sterile chromatography columns maintain sufficient packing media function and maintain column mechanical properties and pressure ratings.
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公开(公告)号：US20190270034A1
公开(公告)日：2019-09-05
申请号：US16308629
申请日：2017-06-12
Applicant: Repligen Corporation
Inventor： Travis R. Ward , James Ronald Peyser , Dana Pentia , Evan Frankel
Abstract: Systems include a chromatography column tube having an inlet and outlet and port assembly arranged in a wall of the column tube between flow distributors that together form a chamber within the tube that is filled with packing medium are described. The port assembly facilitates the removal of resin from the pre-packed column and the port assembly does not affect fluid flow in the normal use of the column for chromatographic separation or ability to maintain sanitary conditions within the column. Also described are methods that include attaching tubing to a pump and to a column inlet and a column outlet, opening the port assembly, attaching tubing to the port assembly and to a second reservoir, and pumping aqueous solution from a reservoir into the chamber and out through the port assembly into the second reservoir, thereby removing packing medium from the column along with the flowing aqueous solution.
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Patent Agency Ranking
公开(公告)号：US20190083903A1
公开(公告)日：2019-03-21
申请号：US16137376
申请日：2018-09-20
Applicant: Repligen Corporation
Inventor： Alan Kit Ho Chan , James Ronald Peyser
Abstract: Methods and systems for removing gases and/or pressure formed during the sterilization, e.g., the gamma irradiation, of prepacked chromatography systems (column plus attached tube and valve set) are described. The methods include purging the gas and/or pressure through specially designed tube and valve sets without breaching the sterility of the prepacked sterile chromatography system. The systems include a sterile or aseptic pre-packed chromatography column including a column having an inlet and an outlet, a tubing and valve set attached to the inlet and the outlet, and a pump configured to pump sterile or aseptic liquid from the fluid source along the tubing and valve set, into the column tube inlet and out of the column tube outlet along a first flow path, thereby removing any entrapped gas and/or pressure from the chamber.
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公开(公告)号：US20220340914A1
公开(公告)日：2022-10-27
申请号：US17782206
申请日：2020-12-10
Applicant: Repligen Corporation
Inventor： Amit Kumar Dutta , James Ronald Peyser
Abstract: This disclosure relates generally to process filtration systems, and more particularly to systems utilizing tangential flow filtration.
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公开(公告)号：US20210096128A1
公开(公告)日：2021-04-01
申请号：US17060546
申请日：2020-10-01
Applicant: Repligen Corporation
Inventor： James Ronald Peyser , Ramsey Shanbaky
IPC: G01N33/566 , G01N30/74 , G01N30/86 , G01N30/28
Abstract: The present disclosure provides systems and methods that allow users to quickly determine titer and remove hold steps by determining a first concentration using slope spectroscopy, depleting the fluid of the expressed protein by selective adsorption, and determining a second concentration using slope spectroscopy. Further, the systems and methods of the present disclosure allows the user to forgo the use of a bioanalyzer or HPLC.
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公开(公告)号：US20240100450A9
公开(公告)日：2024-03-28
申请号：US15890144
申请日：2018-02-06
Applicant: Repligen Corporation
Inventor： James Ronald Peyser , Dana Cristina Pentia
CPC classification number: B01D15/206 , A61L2/081 , A61L2/087 , B01D15/20 , A61L2202/11 , B01D15/327 , B01D15/361 , B01D15/3809
Abstract: If one sterilizes pre-packed, plastic chromatography columns with an appropriate level of gamma irradiation, the resulting sterile chromatography columns maintain sufficient packing media function and maintain column mechanical properties and pressure ratings.
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公开(公告)号：US20160325204A1
公开(公告)日：2016-11-10
申请号：US15109735
申请日：2015-01-16
Applicant: REPLIGEN CORPORATION
Inventor： James Ronald Peyser , Dana Cristina Pentia
CPC classification number: B01D15/206 , A61L2/081 , A61L2/087 , A61L2202/11 , B01D15/20 , B01D15/327 , B01D15/361 , B01D15/3809
Abstract: If one sterilizes pre-packed, plastic chromatography columns with an appropriate level of gamma irradiation, the resulting sterile chromatography columns maintain sufficient packing media function and maintain column mechanical properties and pressure ratings.
Abstract translation: 如果对具有适当水平的γ照射的预先填充的塑料色谱柱进行灭菌，则得到的无菌色谱柱保持足够的填充介质功能并保持色谱柱的机械性能和压力等级。
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