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公开(公告)号：US20160008279A1
公开(公告)日：2016-01-14
申请号：US14659517
申请日：2015-03-16
CPC分类号： A61K9/0087 , A61K33/00 , A61K45/06 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating digestive disorders or at least one symptom thereof. The electrokinetically altered fluid compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said digestive disorders by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids and therapeutic compositions.
摘要翻译： 提供了电动改变的流体（例如，富含气体（例如富氧）电动流体），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以在与电池接触时提供调制 细胞膜电位和细胞膜电导率中的至少一种，以及用于治疗消化系统疾病或其至少一种症状的治疗组合物和方法。 电动改变的流体组合物和方法包括任选与其它治疗剂组合的电动改变的离子水性流体。 特定方面提供通过调节细胞膜，膜电位，膜蛋白例如膜受体（包括但不限于G-蛋白偶联受体（GPCR））中的至少一种来调节或调节与所述消化系统疾病相关的细胞内信号转导和 细胞间连接（例如，紧密连接，间隙连接，zona adherins和desmasomes）。 其它实施方案包括用于电动改变的流体和治疗组合物的特定给药途径或制剂。
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2.发明申请COMPOSITIONS AND METHODS FOR UPREGULATING HIPPOCAMPAL PLASTICITY AND HIPPOCAMPUS-DEPENDENT LEARNING AND MEMORY 审中-公开用于上调海马塑性和依赖海马学习和记忆的组合物和方法公开(公告)号：US20150050344A1
公开(公告)日：2015-02-19
申请号：US14339387
申请日：2014-07-23
CPC分类号： A61K9/51 , A61K9/08 , A61K33/00 , A61K45/06 , A61K2300/00
摘要： Provided are methods for enhancing hippocampal plasticity and hippocampal-mediated learning and memory, and/or enhancing the synaptic maturation of neurons, and/or optimizing or enhancing neuronal synaptic transmission, and/or enhancing intracellular oxygen delivery or utilization, and/or enhancing ATP synthesis, comprising administration, to a subject in need thereof of a sufficient amount over a sufficient time, of an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures (e.g., nanobubbles) having an average diameter of less than 100 nm (e.g., in at least one subject group selected from but not limited to normal subjects, subjects recovering from neurological trauma (e.g., accidents or injury to the brain, stroke, oxygen deprivation, drowning, and asphyxia), and subjects with learning disorders (e.g., dyslexia, dyscalculia, dysgraphia, dyspraxia (sensory integration disorder), dysphasia/aphasia, auditory processing disorder, non-verbal learning disorder, visual processing disorder, and attention deficit disorder (ADD)).
摘要翻译： 提供了用于增强海马可塑性和海马介导的学习和记忆，和/或增强神经元的突触成熟和/或优化或增强神经元突触传递和/或增强细胞内氧递送或利用和/或增强ATP的方法 合成，包括给予有需要的受试者在足够的时间内足够量的具有平均直径小于100nm的电荷稳定的含氧纳米结构（例如纳米气泡）的离子水溶液（例如， 在选自但不限于正常受试者的至少一个受试者群体中，从神经创伤（例如事故或脑损伤，中风，缺氧，溺水和窒息）恢复的受试者以及学习障碍（例如阅读障碍 ，dyscalculia，dysgraphia，dyspraxia（感觉整合障碍），dysphasia /失语症，听觉加工障碍，非语言学习障碍，视觉 加工障碍和注意缺陷障碍（ADD））。
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公开(公告)号：US20140099375A1
公开(公告)日：2014-04-10
申请号：US14103706
申请日：2013-12-11
IPC分类号： A61K9/14 , A61K39/395 , A61K45/06 , A61K31/58
CPC分类号： A61K9/14 , A61K31/573 , A61K31/58 , A61K33/00 , A61K39/395 , A61K45/06 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29D11/00038 , A61K2300/00
摘要： Provided are electrokinetically-altered aqueous fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating an irritation, infection or inflammatory eye condition, comprising administering to, by contacting the eye of a subject in need thereof a therapeutically effective amount of an electrokinetically-altered aqueous fluid. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids) and therapeutic compositions for use in treating eye conditions. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic and/or therapeutic symptom related to eye conditions and/or diseases.
摘要翻译： 提供了电动改变的含水流体（例如，富含气体的电动液），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以提供细胞膜电位和细胞膜电导率中的至少一种的调节，以及 治疗组合物和用于治疗刺激性，感染性或炎症性眼病症的方法，包括通过使需要的受试者的眼睛接触治疗有效量的电动改变的水性液体来施用。 电动改变的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动改变的碘代水性流体。 其它实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体）的特定施用途径或制剂以及用于治疗眼睛状况的治疗组合物。 某些实施方案涉及使用流体处理与眼睛条件和/或疾病相关的化妆品和/或治疗症状的化妆品和/或治疗流体和/或治疗方法。
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公开(公告)号：US20130270478A1
公开(公告)日：2013-10-17
申请号：US13924295
申请日：2013-06-21
IPC分类号： C09K3/00
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： Particular aspects provide compositions comprising an electrokinetically altered oxygenated aqueous fluid, wherein the oxygen in the fluid is present in an amount of at least 25 ppm. In certain aspects, the electrokinetically altered oxygenated aqueous fluid comprises electrokinetically modified or charged oxygen species present in an amount of at least 0.5 ppm. In certain aspects the electrokinetically altered oxygenated aqueous fluid comprises solvated electrons stabilized by molecular oxygen, and wherein the solvated electrons present in an amount of at least 0.01 ppm. In certain aspects, the fluid facilitates oxidation of pyrogallol to purpurogallin in the presence of horseradish peroxidase enzyme (HRP) in an amount above that afforded by a control pressure pot generated or fine-bubble generated aqueous fluid having an equivalent dissolved oxygen level, and wherein there is no hydrogen peroxide, or less than 0.1 ppm of hydrogen peroxide present in the electrokinetic oxygen-enriched aqueous fluid.
摘要翻译： 具体方面提供了包含电动改变的含氧水溶液的组合物，其中流体中的氧以至少25ppm的量存在。 在某些方面，电动改变的含氧水性流体包含以至少0.5ppm的量存在的电动改性或带电的氧物质。 在某些方面，电动改变的含氧水性流体包含由分子氧稳定的溶剂化电子，并且其中溶剂化电子以至少0.01ppm的量存在。 在某些方面，流体有助于在辣根过氧化物酶（HRP）存在下将连苯三酚氧化成紫罗卜糖苷，其量高于由产生的对照压力罐或具有等效溶解氧水平的微小气泡产生的水性流体所提供的量，并且其中 在电动性富氧水溶液中不存在过氧化氢或少于0.1ppm的过氧化氢。
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5.发明申请ELECTROKINETICALLY-ALTERED FLUIDS COMPRISING CHARGE-STABILIZED GAS-CONTAINING NANOSTRUCTURES 有权包含充电稳定性气体纳米结构的电动液态流体公开(公告)号：US20130260462A1
公开(公告)日：2013-10-03
申请号：US13898357
申请日：2013-05-20
CPC分类号： C12N5/0602 , A61K9/0014 , A61K9/0073 , A61K33/00 , A61K41/0004 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29B7/401
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized gas-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids. The electrokinetically-altered fluid compositions and methods of producing the fluid include electrokinetically-altered ionic aqueous fluids optionally in the form of solvated electrons stabilized, at least in part, with molecular gas (e.g., oxygen).
摘要翻译： 提供了电动改变的流体（例如，富氧（例如，富氧）电动流体），其包含电荷稳定的含气体纳米结构的离子水溶液，其量足以在与电池接触时提供调制 细胞膜电位和细胞膜电导率中的至少一种。 进一步提供制备电动改性的离子水性液体组合物的方法。 特定方面提供调节或调节与细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G蛋白偶联受体（GPCR））和细胞间结合（例如，细胞间接合）中的至少一种调节相关的细胞内信号转导。 ，紧密连接处，间隙连接处，扎胶粘合剂和粘胶）。 其它实施方案包括产生电动改变的流体的特定方法。 电动改变的流体组合物和制备流体的方法包括任选以溶剂化电子的形式的电动改变的离子水性流体，至少部分地用分子气体（例如氧）稳定。
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公开(公告)号：US20130092368A1
公开(公告)日：2013-04-18
申请号：US13678948
申请日：2012-11-16
发明人： Anthony B. Wood
CPC分类号： C02F1/20 , A01K63/042 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F3/0857 , B01F7/00758 , B01F7/00783 , B01F7/008 , B01F7/00825 , B01F2003/04687 , B01F2003/04872 , B01F2003/04879 , B01F2215/0052 , B01J19/008 , C02F1/001 , C02F1/34 , C02F1/68 , C02F1/685 , C02F1/727 , C02F1/74 , C02F1/78 , C02F3/205 , C02F9/00 , C02F2101/322 , C02F2303/04 , E21B43/121
摘要： A method of treatment of water in an aquatic environment. Water is first pumped from a reservoir to a first mixing station. An inert gas is introduced into the pumped water at the first mixing station to provide inert gas saturated water, which inert gas saturated water will displace undesired gasses in the water in the reservoir. The inert gas saturated water is then pumped to a sparging column such that the inert gas and undesired gasses will be released from the inert gas saturated water to provide depleted water.
摘要翻译： 在水生环境中处理水的方法。 首先将水从储存器泵送到第一混合站。 将惰性气体引入第一混合站的泵送水中以提供惰性气体饱和水，该惰性气体饱和水将置换储存器中的水中不期望的气体。 然后将惰性气体饱和水泵送到鼓泡塔，使得惰性气体和不需要的气体将从惰性气体饱和水中释放以提供耗尽的水。
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7.发明授权Ionic aqueous solutions comprising charge-stabilized oxygen-containing nanobubbles 有权包含电荷稳定的含氧纳米气泡的离子水溶液公开(公告)号：US09511333B2
公开(公告)日：2016-12-06
申请号：US13851888
申请日：2013-03-27
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids. The electrokinetically-altered fluid compositions and methods of producing the fluid include electrokinetically-altered ionic aqueous fluids optionally in the form of solvated electrons stabilized with molecular oxygen.
摘要翻译： 提供了电动改变的流体（例如，富含气体（例如富氧）电动流体），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以在与电池接触时提供调制 细胞膜电位和细胞膜电导率中的至少一种。 进一步提供制备电动改性的离子水性液体组合物的方法。 特定方面提供调节或调节与细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G蛋白偶联受体（GPCR））和细胞间结合（例如，细胞间接合）中的至少一种调节相关的细胞内信号转导。 ，紧密连接处，间隙连接处，扎胶粘合剂和粘胶）。 其它实施方案包括产生电动改变的流体的特定方法。 电动改变的流体组合物和制备流体的方法包括任选地以分子氧稳定的溶剂化电子的形式的电动改变的离子水性流体。
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8.发明申请COMPOSITIONS AND METHODS FOR TREATING INSULIN RESISTANCE AND DIABETES MELLITUS 有权用于治疗胰岛素抵抗和糖尿病的组合物和方法公开(公告)号：US20150050346A1
公开(公告)日：2015-02-19
申请号：US14467821
申请日：2014-08-25
CPC分类号： A61K33/14 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/08 , A61K9/14 , A61K31/138 , A61K31/45 , A61K31/58 , A61K41/00 , A61K41/0004 , A61K45/06 , A61K47/02 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating diabetes and diabetes-associated conditions or disorders (e.g., insulin resistance), or symptoms thereof. Provided are electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译： 提供了电动改变的流体（富含气体的电动液），其包含足以提供细胞膜电位和细胞膜电导率中的至少一种的调节的电荷稳定的含氧纳米结构的离子水溶液，以及治疗组合物和 用于治疗糖尿病和糖尿病相关病症或障碍（例如，胰岛素抵抗）的方法或其症状。 提供任选与其它治疗剂组合的电动学改变的碘含量水性流体。 特定方面通过调节细胞膜，膜电位，膜蛋白例如膜受体（包括但不限于G-蛋白偶联受体（GPCR））和细胞间质细胞间的至少一种来调节或调节与所述应答相关的细胞内信号转导 交界处（例如，紧密连接处，间隙连接处，粘合层和脱水垫）。 其他实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。
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公开(公告)号：US20140086963A1
公开(公告)日：2014-03-27
申请号：US14091192
申请日：2013-11-26
IPC分类号： A61K33/00
CPC分类号： A61K9/0014 , A61K9/0048 , A61K33/00 , A61K33/14 , A61K45/06 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29D11/00038 , B29D11/00096 , A61K2300/00
摘要： Particular embodiments disclosed herein relate to gas-enriched fluids, methods of making the same, systems for making the same and/or methods of treatment utilizing the gas-enriched fluids for wound care related conditions and/or diseases. In certain embodiments, the gas-enriched fluid is oxygen-enriched water. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids in order to treat a cosmetic and/or therapeutic symptom of wound care and/or increase proper wound healing.
摘要翻译： 本文公开的具体实施方案涉及富含气体的流体，其制备方法，制备方法，和/或利用富含气体的流体处理伤口护理相关病症和/或疾病的治疗方法。 在某些实施方案中，富含气体的流体是富氧水。 某些实施方案涉及使用流体的化妆品和/或治疗性流体和/或治疗方法，以便治疗伤口护理的化妆品和/或治疗症状和/或增加适当的伤口愈合。
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10.发明授权Ionic aqueous solutions comprising charge-stabilized oxygen-containing nanobubbles 有权包含电荷稳定的含氧纳米气泡的离子水溶液公开(公告)号：US09512398B2
公开(公告)日：2016-12-06
申请号：US13898357
申请日：2013-05-20
CPC分类号： C12N5/0602 , A61K9/0014 , A61K9/0073 , A61K33/00 , A61K41/0004 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29B7/401
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized gas-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids. The electrokinetically-altered fluid compositions and methods of producing the fluid include electrokinetically-altered ionic aqueous fluids optionally in the form of solvated electrons stabilized, at least in part, with molecular gas (e.g., oxygen).
摘要翻译： 提供了电动改变的流体（例如，富氧（例如，富氧）电动流体），其包含电荷稳定的含气体纳米结构的离子水溶液，其量足以在与电池接触时提供调制 细胞膜电位和细胞膜电导率中的至少一种。 进一步提供制备电动改性的离子水性液体组合物的方法。 特定方面提供调节或调节与细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G蛋白偶联受体（GPCR））和细胞间结合（例如，细胞间接合）中的至少一种调节相关的细胞内信号转导。 ，紧密连接处，间隙连接处，扎胶粘合剂和粘胶）。 其它实施方案包括产生电动改变的流体的特定方法。 电动改变的流体组合物和制备流体的方法包括任选以溶剂化电子的形式的电动改变的离子水性流体，至少部分地用分子气体（例如氧）稳定。
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