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1.发明申请SUBSTITUTED PIPERAZINES, (1,4) DIAZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS 审中-公开替代哌嗪，（1,4）双嘧达嗪和2,5-DIAZABICYCLO（2.2.1）作为组胺H1和/或H3拮抗剂或组胺H3逆转拮抗剂的HEPTANES公开(公告)号：US20100075953A1
公开(公告)日：2010-03-25
申请号：US12562285
申请日：2009-09-18
申请人： Rachael Ancliff , Colin David Eldred , Ashley Paul Hancock , Thomas Daniel Heightman , Heather Hobbs , Simon Teanby Hodgson , David Matthew Wilson
发明人： Rachael Ancliff , Colin David Eldred , Ashley Paul Hancock , Thomas Daniel Heightman , Heather Hobbs , Simon Teanby Hodgson , David Matthew Wilson
IPC分类号： A61K31/496 , A61K31/55 , A61K31/551 , A61K31/541 , A61K31/538 , C07D403/12 , C07D405/14 , C07D417/12 , C07D401/12 , C07D401/14 , A61P11/00
CPC分类号： C07D213/81 , C07D209/42 , C07D211/46 , C07D213/50 , C07D213/64 , C07D215/40 , C07D215/46 , C07D215/50 , C07D239/28 , C07D243/08 , C07D265/36 , C07D277/62 , C07D285/06 , C07D295/088 , C07D295/185 , C07D295/192 , C07D295/215 , C07D295/26 , C07D307/79 , C07D307/85 , C07D311/84 , C07D317/68 , C07D333/38 , C07D405/06 , C07D487/08 , C07D491/04
摘要： The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.
摘要翻译： 本发明涉及具有药理活性的新颖的哌嗪和吖庚因衍生物，其制备方法，含有它们的组合物及其在治疗包括阿尔茨海默病的神经变性疾病中的用途。
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2.发明授权Substituted piperazines,(1,4) diazepines, and 2,5-diazabicyclo (2.2.1)iieptanes as histamine H1 and/or H3 antagonists or histamine H3 reverse antagonists 失效作为组胺H1和/或H3拮抗剂或组胺H3反向拮抗剂的取代的哌嗪，（1,4）二氮杂和2,5-二氮杂双环（2.2.1）公开(公告)号：US07615550B2
公开(公告)日：2009-11-10
申请号：US10531758
申请日：2003-10-14
IPC分类号： A61P11/00 , A61P25/00 , A61K31/496 , C07D243/08 , C07D295/00 , C07D307/85 , C07D311/90 , C07D317/68 , C07D333/38 , C07D401/12 , C07D403/12 , C07D405/06 , C07D487/08 , C07D491/04
CPC分类号： C07D213/81 , C07D209/42 , C07D211/46 , C07D213/50 , C07D213/64 , C07D215/40 , C07D215/46 , C07D215/50 , C07D239/28 , C07D243/08 , C07D265/36 , C07D277/62 , C07D285/06 , C07D295/088 , C07D295/185 , C07D295/192 , C07D295/215 , C07D295/26 , C07D307/79 , C07D307/85 , C07D311/84 , C07D317/68 , C07D333/38 , C07D405/06 , C07D487/08 , C07D491/04
摘要： The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.
摘要翻译： 本发明涉及具有药理活性的新颖的哌嗪和吖庚因衍生物，其制备方法，含有它们的组合物及其在治疗包括阿尔茨海默病的神经变性疾病中的用途。
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公开(公告)号：US08329730B2
公开(公告)日：2012-12-11
申请号：US12989700
申请日：2009-04-29
IPC分类号： C07D413/04 , A61K31/4725
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种病症中的用途。
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公开(公告)号：US20110039889A1
公开(公告)日：2011-02-17
申请号：US12989700
申请日：2009-04-29
IPC分类号： A61K31/4709 , C07D413/10 , C07D413/14 , A61P19/02
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种病症中的用途。
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公开(公告)号：US08222245B2
公开(公告)日：2012-07-17
申请号：US12747205
申请日：2008-12-19
申请人： Emmanuel Hubert Demont , Jag Paul Heer , John Skidmore , Ian David Wall , Jason Witherington , Thomas Daniel Heightman , David Nigel Hurst , Christopher Norbert Johnson
发明人： Emmanuel Hubert Demont , Jag Paul Heer , John Skidmore , Ian David Wall , Jason Witherington , Thomas Daniel Heightman , David Nigel Hurst , Christopher Norbert Johnson
IPC分类号： A61P17/00 , A61P37/00 , A61K31/55 , C07D223/16 , C07D267/14 , C07D271/06 , C07D413/04 , C07D413/14
CPC分类号： C07D223/16 , C07D267/14 , C07D271/06 , C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种病症中的用途。
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![N-[(3,5-DICHLOROPHENYL)METHYL]-2-(4-METHYL-1-PIPERAZINYL)-2-(1-NAPHTHALENYL)ETHANAMIDE AS GHRELIN RECEPTOR MODULATOR](/abs-image/US/2010/10/21/US20100267734A1/abs.jpg.150x150.jpg)
6.发明申请N-[(3,5-DICHLOROPHENYL)METHYL]-2-(4-METHYL-1-PIPERAZINYL)-2-(1-NAPHTHALENYL)ETHANAMIDE AS GHRELIN RECEPTOR MODULATOR 审中-公开N - [（3,5-二氯苯基）甲基] -2-（4-甲基-1-哌嗪基）-2-（1-萘甲酰）乙酰胺作为GHRELIN受体调节剂公开(公告)号：US20100267734A1
公开(公告)日：2010-10-21
申请号：US12602834
申请日：2008-06-05
IPC分类号： A61K31/495 , C07D241/04 , A61P3/00
CPC分类号： C07D295/15
摘要： The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, processes for their preparation, intermediates useable in these processes, pharmaceutical compositions containing them and their use in therapy, for example as modulators of the growth hormone secretagogue receptor (also referred to as the ghrelin receptor or GHSR1a receptor) and/or for the treatment and/or prophylaxis of a disorder mediated by the ghrelin receptor.
摘要翻译： 本发明涉及新的式（I）化合物或其药学上可接受的盐或溶剂化物，其制备方法，可用于这些方法的中间体，含有它们的药物组合物及其在治疗中的用途，例如作为生长激素的调节剂 促分泌素受体（也称为生长素释放肽受体或GHSR1a受体）和/或用于治疗和/或预防由生长素释放肽受体介导的病症。
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公开(公告)号：US20140179666A1
公开(公告)日：2014-06-26
申请号：US14112597
申请日：2012-04-20
申请人： Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
发明人： Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
IPC分类号： C07D471/04 , C07D403/14 , C07D487/10 , C07D403/06 , C07D471/10
CPC分类号： C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
摘要： The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及式（I）的双环杂环化合物：或互变异构体或立体化学异构形式，N-氧化物，药学上可接受的盐或其溶剂合物; 其中R1，R2a，R2b，R3a，R3b，R5，R6，R7，R8，R9，p和E如本文所定义; 包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US08278324B2
公开(公告)日：2012-10-02
申请号：US12747191
申请日：2008-12-19
IPC分类号： C07D413/04 , A61K31/4725
CPC分类号： C07D217/06 , C07D217/16 , C07D217/22 , C07D413/04
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
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公开(公告)号：US20100273771A1
公开(公告)日：2010-10-28
申请号：US12747205
申请日：2008-12-19
申请人： Emmanuel Hubert Demont , Jag Paul Heer , John Skidmore , Ian David Wall , Jason Witherington , Thomas Daniel Heightman , David Nigel Hurst , Christopher Norbert Johnson
发明人： Emmanuel Hubert Demont , Jag Paul Heer , John Skidmore , Ian David Wall , Jason Witherington , Thomas Daniel Heightman , David Nigel Hurst , Christopher Norbert Johnson
IPC分类号： A61K31/553 , C07D413/10 , A61K31/55 , A61P37/00
CPC分类号： C07D223/16 , C07D267/14 , C07D271/06 , C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
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公开(公告)号：US20100152235A1
公开(公告)日：2010-06-17
申请号：US12711318
申请日：2010-02-24
IPC分类号： A61K31/4725 , C07D413/02
CPC分类号： C07D217/06 , C07D217/16 , C07D217/22 , C07D413/04
摘要： The present invention relates to a novel oxadiazole derivative having pharmacological activity, processes for its preparation, pharmaceutical compositions containing it and its use in the treatment of various disorders.
摘要翻译： 本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它的药物组合物及其在治疗各种疾病中的用途。
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