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    Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function
    1.
    发明申请
    Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function 有权
    荧光吡嗪衍生物及其在肾功能评估中的应用方法

    公开(公告)号：US20090010851A1

    公开(公告)日：2009-01-08

    申请号：US11721186

    申请日：2005-12-22

    申请人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    IPC分类号： A61K49/00

    CPC分类号： C07D241/28 ,  A61K31/4965 ,  A61K49/0004 ,  A61K49/0021 ,  A61K49/0052 ,  C07D241/20 ,  C07D241/26

    摘要： The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X1 to X4 of Formulas I and II may be characterized as electron withdrawing groups, while Y1 to Y4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.

    摘要翻译： 本发明涉及吡嗪衍生物，例如由式I和II表示的衍生物。 式I和II的X 1至X 4可以表征为吸电子基团，而式I和II的Y1至Y4可以表征为给电子基团。 本发明的吡嗪衍生物可用于评估器官（例如肾）功能。 在具体实例中，有效量的能够被再次清除的吡嗪衍生物可以被施用到患者体内。 吡嗪衍生物可以具有一个或两个吸收和发射至少约400nm的光谱能量（例如可见光和/或红外光）。 身体中的至少一些衍生物可能暴露于光谱能量，反过来，光谱能量可能来自衍生物。 这种发出的光谱能量可以被检测并用于确定患者的肾功能。

    Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function
    2.
    发明申请
    Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function 有权
    荧光吡嗪衍生物及其在肾功能评估中的应用方法

    公开(公告)号：US20140039191A1

    公开(公告)日：2014-02-06

    申请号：US14047733

    申请日：2013-10-07

    申请人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    IPC分类号： C07D241/28 ,  C07D241/20

    CPC分类号： C07D241/28 ,  A61K31/4965 ,  A61K49/0004 ,  A61K49/0021 ,  A61K49/0052 ,  C07D241/20 ,  C07D241/26

    摘要： The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X1 to X4 of Formulas I and II may be characterized as electron withdrawing groups, while Y1 to Y4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.

    摘要翻译： 本发明涉及吡嗪衍生物，例如由式I和II表示的衍生物。 式I和II的X 1至X 4可以表征为吸电子基团，而式I和II的Y1至Y4可以表征为给电子基团。 本发明的吡嗪衍生物可用于评估器官（例如肾）功能。 在具体实例中，有效量的能够被再次清除的吡嗪衍生物可以被施用到患者体内。 吡嗪衍生物可以具有一个或两个吸收和发射至少约400nm的光谱能量（例如可见光和/或红外光）。 身体中的至少一些衍生物可能暴露于光谱能量，反过来，光谱能量可能来自衍生物。 这种发出的光谱能量可以被检测并用于确定患者的肾功能。

    Integrated photoactive small molecules and uses thereof
    3.
    发明授权
    Integrated photoactive small molecules and uses thereof 有权
    综合光敏小分子及其用途

    公开(公告)号：US08313729B2

    公开(公告)日：2012-11-20

    申请号：US12528630

    申请日：2008-02-26

    申请人： William L. Neumann ,  Raghavan Rajagopalan ,  Dennis A. Moore ,  Richard B. Dorshow

    发明人： William L. Neumann ,  Raghavan Rajagopalan ,  Dennis A. Moore ,  Richard B. Dorshow

    IPC分类号： A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00

    CPC分类号： A61K49/001 ,  A61K41/0019 ,  A61K47/60 ,  A61K49/0021 ,  A61K49/0052

    摘要： This invention is directed to the general method of transforming non-photoactive bioactive small molecule compounds of known structure and function into photoactive analogs of the small molecules which exhibit both photoactivity and the original biological targeting activity. The general method for the design of the photoactive analogs of the small molecules includes: (a) selecting a desired bioactive molecule; (b) identifying the region of the molecule that contains an aromatic or a heteroaromatic motif; and (c) either replacing said motif with a photoactive functional group of similar size, or modifying said motif to make it photoactive. Other aspects include photoactive analog compounds and photodiagnostic and phototherapeutic uses thereof.

    摘要翻译： 本发明涉及将具有已知结构和功能的非光活性生物活性小分子化合物转化为具有光活性和原始生物靶向活性的小分子的光活性类似物的一般方法。 设计小分子的光活性类似物的一般方法包括：（a）选择所需的生物活性分子; （b）鉴定含有芳族或杂芳族基序的分子的区域; 和（c）用相似尺寸的光活性官能团取代所述基序，或修饰所述基序以使其具有光活性。 其他方面包括光敏类似物化合物及其光诊断和光治疗用途。

    LUMINESCENT METAL COMPLEXES FOR MONITORING RENAL FUNCTION
    4.
    发明申请
    LUMINESCENT METAL COMPLEXES FOR MONITORING RENAL FUNCTION 审中-公开
    用于监测肾功能的发光金属复合物

    公开(公告)号：US20100113756A1

    公开(公告)日：2010-05-06

    申请号：US12683851

    申请日：2010-01-07

    申请人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  Dennis A. Moore

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  Dennis A. Moore

    IPC分类号： C07F5/00

    CPC分类号： C09K11/06 ,  A61K49/0013 ,  C07C237/02 ,  C07C237/12 ,  C09K2211/188

    摘要： Some embodiments of the present invention may be said to be directed to metal complexes of Formula I wherein at least one of X1, X2, X3, R1, R2, R3, R4 or R5 is what may be characterized as an antenna capable of providing (e.g., absorbing and/or emitting) an appropriate electromagnetic signal. Some embodiments of the present invention are directed to ligands corresponding to metal complexes of Formula I. Some embodiments of the invention are directed to methods of determining renal function using at least one metal complex of Formula I.

    摘要翻译： 可以说本发明的一些实施方案涉及式I的金属络合物，其中X 1，X 2，X 3，R 1，R 2，R 3，R 4或R 5中的至少一个可被表征为能够提供（ 例如吸收和/或发射）适当的电磁信号。 本发明的一些实施方案涉及对应于式I的金属配合物的配体。本发明的一些实施方案涉及使用至少一种式I的金属络合物测定肾功能的方法。

    Luminescent metal complexes for monitoring renal function
    5.
    发明授权
    Luminescent metal complexes for monitoring renal function 有权
    用于监测肾功能的发光金属络合物

    公开(公告)号：US07674902B2

    公开(公告)日：2010-03-09

    申请号：US11572920

    申请日：2005-08-03

    申请人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  Dennis A. Moore

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  Dennis A. Moore

    IPC分类号： C07D471/00

    CPC分类号： C09K11/06 ,  A61K49/0013 ,  C07C237/02 ,  C07C237/12 ,  C09K2211/188

    摘要： Some embodiments of the present invention may be said to be directed to metal complexes of Formula I, wherein at least one of X1, X2, X3, R1, R2, R3, R4 and R5 is what may be characterized as an antenna capable of providing (e.g., absorbing and/or emitting) an appropriate electromagnetic signal. Some embodiments of the present invention are directed to ligands corresponding to metal complexes of Formula I. Some embodiments of the invention are directed to methods of determining renal function using at least one metal complex of Formula I.

    摘要翻译： 可以说本发明的一些实施方案涉及式I的金属络合物，其中X 1，X 2，X 3，R 1，R 2，R 3，R 4和R 5中的至少一个是可以被表征为能够提供 （例如，吸收和/或发射）适当的电磁信号。 本发明的一些实施方案涉及对应于式I的金属配合物的配体。本发明的一些实施方案涉及使用至少一种式I的金属络合物测定肾功能的方法。

    Methods for Using Optical Agents
    6.
    发明申请
    Methods for Using Optical Agents 审中-公开
    光学剂的使用方法

    公开(公告)号：US20100047173A1

    公开(公告)日：2010-02-25

    申请号：US12515294

    申请日：2007-11-13

    申请人： Richard B. Dorshow ,  Raghavan Rajagopalan ,  Dennis A. Moore

    发明人： Richard B. Dorshow ,  Raghavan Rajagopalan ,  Dennis A. Moore

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0034 ,  A61K49/0043

    摘要： In certain embodiments, the present invention is directed to novel processes for using hepatobiliary cleared optical agents to detect one or more tissues of the biliary tract of a surgical patient. In certain embodiments, the invention is directed to kits that include one or more optical agents and instructions for using the agent(s), for example, in a process of the invention.

    摘要翻译： 在某些实施方案中，本发明涉及使用肝胆清除的光学剂来检测手术患者的胆道的一个或多个组织的新方法。 在某些实施方案中，本发明涉及包含一种或多种光学试剂的试剂盒，以及例如在本发明的方法中使用该试剂的说明书。

    Fluorescent pyrazine derivatives and methods of using the same in assessing renal function
    8.
    发明授权
    Fluorescent pyrazine derivatives and methods of using the same in assessing renal function 有权
    荧光吡嗪衍生物及其在肾功能评估中的应用

    公开(公告)号：US08778309B2

    公开(公告)日：2014-07-15

    申请号：US11721186

    申请日：2005-12-22

    申请人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann ,  Dennis A. Moore

    IPC分类号： A61B5/20 ,  C07D241/02

    CPC分类号： C07D241/28 ,  A61K31/4965 ,  A61K49/0004 ,  A61K49/0021 ,  A61K49/0052 ,  C07D241/20 ,  C07D241/26

    摘要： The present invention relates to pyrazine derivatives represented by Formula I. X1 and X2 of Formula I may be characterized as electron withdrawing groups, while Y1 and Y2 of Formula I may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may be capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient

    摘要翻译： 本发明涉及由式I表示的吡嗪衍生物。式I的X1和X2可以表征为吸电子基团，而式I的Y1和Y2可以表征为给电子基团。 本发明的吡嗪衍生物可用于评估器官（例如肾）功能。 在具体实例中，有效量的能够被再次清除的吡嗪衍生物可以被施用到患者体内。 吡嗪衍生物可以具有至少约400nm的吸收和发射光谱能量（例如可见光和/或红外光）的一种或两种。 身体中的至少一些衍生物可能暴露于光谱能量，反过来，光谱能量可能来自衍生物。 这种发出的光谱能量可以被检测并用于确定患者的肾功能

    Integrated Photoactive Small Molecules and Uses Thereof
    9.
    发明申请
    Integrated Photoactive Small Molecules and Uses Thereof 有权
    综合光敏小分子及其用途

    公开(公告)号：US20100105899A1

    公开(公告)日：2010-04-29

    申请号：US12528630

    申请日：2008-02-26

    申请人： William L. Neumann ,  Raghavan Rajagopalan ,  Dennis A. Moore ,  Richard B. Dorshow

    发明人： William L. Neumann ,  Raghavan Rajagopalan ,  Dennis A. Moore ,  Richard B. Dorshow

    IPC分类号： C07D413/04 ,  C07D241/20

    CPC分类号： A61K49/001 ,  A61K41/0019 ,  A61K47/60 ,  A61K49/0021 ,  A61K49/0052

    摘要： This invention is directed to the general method of transforming non-photoactive bioactive small molecule compounds of known structure and function into photoactive analogs of the small molecules which exhibit both photoactivity and the original biological targeting activity. The general method for the design of the photoactive analogs of the small molecules includes: (a) selecting a desired bioactive molecule; (b) identifying the region of the molecule that contains an aromatic or a heteroaromatic motif; and (c) either replacing said motif with a photoactive functional group of similar size, or modifying said motif to make it photoactive. Other aspects include photoactive analog compounds and photodiagnostic and phototherapeutic uses thereof.

    摘要翻译： 本发明涉及将具有已知结构和功能的非光活性生物活性小分子化合物转化为具有光活性和原始生物靶向活性的小分子的光活性类似物的一般方法。 设计小分子的光活性类似物的一般方法包括：（a）选择所需的生物活性分子; （b）鉴定含有芳族或杂芳族基序的分子的区域; 和（c）用相似尺寸的光活性官能团取代所述基序，或修饰所述基序以使其具有光活性。 其他方面包括光敏类似物化合物及其光诊断和光治疗用途。