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公开(公告)号：US09283288B2
公开(公告)日：2016-03-15
申请号：US11995270
申请日：2006-10-11
CPC分类号： A61K49/0021 , A61B5/0059 , A61B5/0071 , A61B5/0077 , A61B5/20 , A61B5/418 , A61B5/4836 , A61B2017/00022 , A61B2017/00274 , A61B2017/00823 , A61B2017/4216 , A61B2017/4233 , A61B2562/0233
摘要： In certain aspects, the invention relates to processes for using renally excretable optical agents to detect one or more tissues of the renal system of a surgical patient. In certain aspects, the invention relates to a kit including a biocompatible composition containing one or more optical agents and instructions for using the optical agent(s) in a process of the present invention.
摘要翻译： 在某些方面，本发明涉及使用可再分泌的光学剂来检测手术患者的肾系统的一个或多个组织的方法。 在某些方面，本发明涉及一种试剂盒，其包含含有一种或多种光学剂的生物相容性组合物和在本发明的方法中使用光学剂的说明书。
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公开(公告)号：US20080312539A1
公开(公告)日：2008-12-18
申请号：US11995270
申请日：2006-10-11
CPC分类号： A61K49/0021 , A61B5/0059 , A61B5/0071 , A61B5/0077 , A61B5/20 , A61B5/418 , A61B5/4836 , A61B2017/00022 , A61B2017/00274 , A61B2017/00823 , A61B2017/4216 , A61B2017/4233 , A61B2562/0233
摘要： In certain aspects, the invention relates to processes for using renally excretable optical agents to detect one or more tissues of the renal system of a surgical patient. In certain aspects, the invention relates to a kit including a biocompatible composition containing one or more optical agents and instructions for using the optical agent(s) in a process of the present invention.
摘要翻译： 在某些方面，本发明涉及使用可再分泌的光学剂来检测手术患者的肾系统的一个或多个组织的方法。 在某些方面，本发明涉及一种试剂盒，其包含含有一种或多种光学剂的生物相容性组合物和在本发明的方法中使用光学剂的说明书。
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3.发明申请Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function 有权荧光吡嗪衍生物及其在肾功能评估中的应用方法公开(公告)号：US20090010851A1
公开(公告)日：2009-01-08
申请号：US11721186
申请日：2005-12-22
IPC分类号： A61K49/00
CPC分类号： C07D241/28 , A61K31/4965 , A61K49/0004 , A61K49/0021 , A61K49/0052 , C07D241/20 , C07D241/26
摘要： The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X1 to X4 of Formulas I and II may be characterized as electron withdrawing groups, while Y1 to Y4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.
摘要翻译： 本发明涉及吡嗪衍生物，例如由式I和II表示的衍生物。 式I和II的X 1至X 4可以表征为吸电子基团，而式I和II的Y1至Y4可以表征为给电子基团。 本发明的吡嗪衍生物可用于评估器官（例如肾）功能。 在具体实例中，有效量的能够被再次清除的吡嗪衍生物可以被施用到患者体内。 吡嗪衍生物可以具有一个或两个吸收和发射至少约400nm的光谱能量（例如可见光和/或红外光）。 身体中的至少一些衍生物可能暴露于光谱能量，反过来，光谱能量可能来自衍生物。 这种发出的光谱能量可以被检测并用于确定患者的肾功能。
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4.发明授权Fluorescent pyrazine derivatives and methods of using the same in assessing renal function 有权荧光吡嗪衍生物及其在肾功能评估中的应用公开(公告)号：US08778309B2
公开(公告)日：2014-07-15
申请号：US11721186
申请日：2005-12-22
IPC分类号： A61B5/20 , C07D241/02
CPC分类号： C07D241/28 , A61K31/4965 , A61K49/0004 , A61K49/0021 , A61K49/0052 , C07D241/20 , C07D241/26
摘要： The present invention relates to pyrazine derivatives represented by Formula I. X1 and X2 of Formula I may be characterized as electron withdrawing groups, while Y1 and Y2 of Formula I may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may be capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient
摘要翻译： 本发明涉及由式I表示的吡嗪衍生物。式I的X1和X2可以表征为吸电子基团，而式I的Y1和Y2可以表征为给电子基团。 本发明的吡嗪衍生物可用于评估器官（例如肾）功能。 在具体实例中，有效量的能够被再次清除的吡嗪衍生物可以被施用到患者体内。 吡嗪衍生物可以具有至少约400nm的吸收和发射光谱能量（例如可见光和/或红外光）的一种或两种。 身体中的至少一些衍生物可能暴露于光谱能量，反过来，光谱能量可能来自衍生物。 这种发出的光谱能量可以被检测并用于确定患者的肾功能
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公开(公告)号：US20100105899A1
公开(公告)日：2010-04-29
申请号：US12528630
申请日：2008-02-26
IPC分类号： C07D413/04 , C07D241/20
CPC分类号： A61K49/001 , A61K41/0019 , A61K47/60 , A61K49/0021 , A61K49/0052
摘要： This invention is directed to the general method of transforming non-photoactive bioactive small molecule compounds of known structure and function into photoactive analogs of the small molecules which exhibit both photoactivity and the original biological targeting activity. The general method for the design of the photoactive analogs of the small molecules includes: (a) selecting a desired bioactive molecule; (b) identifying the region of the molecule that contains an aromatic or a heteroaromatic motif; and (c) either replacing said motif with a photoactive functional group of similar size, or modifying said motif to make it photoactive. Other aspects include photoactive analog compounds and photodiagnostic and phototherapeutic uses thereof.
摘要翻译： 本发明涉及将具有已知结构和功能的非光活性生物活性小分子化合物转化为具有光活性和原始生物靶向活性的小分子的光活性类似物的一般方法。 设计小分子的光活性类似物的一般方法包括：（a）选择所需的生物活性分子; （b）鉴定含有芳族或杂芳族基序的分子的区域; 和（c）用相似尺寸的光活性官能团取代所述基序，或修饰所述基序以使其具有光活性。 其他方面包括光敏类似物化合物及其光诊断和光治疗用途。
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公开(公告)号：US20080299038A1
公开(公告)日：2008-12-04
申请号：US11572920
申请日：2005-08-03
CPC分类号： C09K11/06 , A61K49/0013 , C07C237/02 , C07C237/12 , C09K2211/188
摘要： Some embodiments of the present invention may be said to be directed to metal complexes of Formula I, wherein at least one of X1, X2, X3, R1, R2, R3, R4 and R5 is what may be characterized as an antenna capable of providing (e.g., absorbing and/or emitting) an appropriate electromagnetic signal. Some embodiments of the present invention are directed to ligands corresponding to metal complexes of Formula I. Some embodiments of the invention are directed to methods of determining renal function using at least one metal complex of Formula I.
摘要翻译： 可以说本发明的一些实施方案涉及式I的金属络合物，其中X 1，X 2，X 3，R 1，R 2，R 3，R 4和R 5中的至少一个是可以被表征为能够提供 （例如，吸收和/或发射）适当的电磁信号。 本发明的一些实施方案涉及对应于式I的金属配合物的配体。本发明的一些实施方案涉及使用至少一种式I的金属络合物测定肾功能的方法。
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7.发明申请Fluorescent Pyrazine Derivatives and Methods of Using the Same in Assessing Renal Function 有权荧光吡嗪衍生物及其在肾功能评估中的应用方法公开(公告)号：US20140039191A1
公开(公告)日：2014-02-06
申请号：US14047733
申请日：2013-10-07
IPC分类号： C07D241/28 , C07D241/20
CPC分类号： C07D241/28 , A61K31/4965 , A61K49/0004 , A61K49/0021 , A61K49/0052 , C07D241/20 , C07D241/26
摘要： The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X1 to X4 of Formulas I and II may be characterized as electron withdrawing groups, while Y1 to Y4 of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.
摘要翻译： 本发明涉及吡嗪衍生物，例如由式I和II表示的衍生物。 式I和II的X 1至X 4可以表征为吸电子基团，而式I和II的Y1至Y4可以表征为给电子基团。 本发明的吡嗪衍生物可用于评估器官（例如肾）功能。 在具体实例中，有效量的能够被再次清除的吡嗪衍生物可以被施用到患者体内。 吡嗪衍生物可以具有一个或两个吸收和发射至少约400nm的光谱能量（例如可见光和/或红外光）。 身体中的至少一些衍生物可能暴露于光谱能量，反过来，光谱能量可能来自衍生物。 这种发出的光谱能量可以被检测并用于确定患者的肾功能。
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公开(公告)号：US08313729B2
公开(公告)日：2012-11-20
申请号：US12528630
申请日：2008-02-26
CPC分类号： A61K49/001 , A61K41/0019 , A61K47/60 , A61K49/0021 , A61K49/0052
摘要： This invention is directed to the general method of transforming non-photoactive bioactive small molecule compounds of known structure and function into photoactive analogs of the small molecules which exhibit both photoactivity and the original biological targeting activity. The general method for the design of the photoactive analogs of the small molecules includes: (a) selecting a desired bioactive molecule; (b) identifying the region of the molecule that contains an aromatic or a heteroaromatic motif; and (c) either replacing said motif with a photoactive functional group of similar size, or modifying said motif to make it photoactive. Other aspects include photoactive analog compounds and photodiagnostic and phototherapeutic uses thereof.
摘要翻译： 本发明涉及将具有已知结构和功能的非光活性生物活性小分子化合物转化为具有光活性和原始生物靶向活性的小分子的光活性类似物的一般方法。 设计小分子的光活性类似物的一般方法包括：（a）选择所需的生物活性分子; （b）鉴定含有芳族或杂芳族基序的分子的区域; 和（c）用相似尺寸的光活性官能团取代所述基序，或修饰所述基序以使其具有光活性。 其他方面包括光敏类似物化合物及其光诊断和光治疗用途。
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公开(公告)号：US20100113756A1
公开(公告)日：2010-05-06
申请号：US12683851
申请日：2010-01-07
IPC分类号： C07F5/00
CPC分类号： C09K11/06 , A61K49/0013 , C07C237/02 , C07C237/12 , C09K2211/188
摘要： Some embodiments of the present invention may be said to be directed to metal complexes of Formula I wherein at least one of X1, X2, X3, R1, R2, R3, R4 or R5 is what may be characterized as an antenna capable of providing (e.g., absorbing and/or emitting) an appropriate electromagnetic signal. Some embodiments of the present invention are directed to ligands corresponding to metal complexes of Formula I. Some embodiments of the invention are directed to methods of determining renal function using at least one metal complex of Formula I.
摘要翻译： 可以说本发明的一些实施方案涉及式I的金属络合物，其中X 1，X 2，X 3，R 1，R 2，R 3，R 4或R 5中的至少一个可被表征为能够提供（ 例如吸收和/或发射）适当的电磁信号。 本发明的一些实施方案涉及对应于式I的金属配合物的配体。本发明的一些实施方案涉及使用至少一种式I的金属络合物测定肾功能的方法。
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公开(公告)号：US07674902B2
公开(公告)日：2010-03-09
申请号：US11572920
申请日：2005-08-03
IPC分类号： C07D471/00
CPC分类号： C09K11/06 , A61K49/0013 , C07C237/02 , C07C237/12 , C09K2211/188
摘要： Some embodiments of the present invention may be said to be directed to metal complexes of Formula I, wherein at least one of X1, X2, X3, R1, R2, R3, R4 and R5 is what may be characterized as an antenna capable of providing (e.g., absorbing and/or emitting) an appropriate electromagnetic signal. Some embodiments of the present invention are directed to ligands corresponding to metal complexes of Formula I. Some embodiments of the invention are directed to methods of determining renal function using at least one metal complex of Formula I.
摘要翻译： 可以说本发明的一些实施方案涉及式I的金属络合物，其中X 1，X 2，X 3，R 1，R 2，R 3，R 4和R 5中的至少一个是可以被表征为能够提供 （例如，吸收和/或发射）适当的电磁信号。 本发明的一些实施方案涉及对应于式I的金属配合物的配体。本发明的一些实施方案涉及使用至少一种式I的金属络合物测定肾功能的方法。
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