-
公开(公告)号：US06509318B1
公开(公告)日：2003-01-21
申请号：US09676108
申请日：2000-09-29
IPC分类号： A61K3803
CPC分类号： C07K14/78 , A61K38/00 , C07K14/495
摘要： A family of small peptides have been found to be inhibitory to TGF-&bgr; activity, and preferably have the primary structure of Formula I: AA1-AA2-AA3-Pro-D-Glu-Ala FORMULA I wherein AA1 is leucine, phenylalanine, &agr;-aminoisobutric acid, N-methylalanine, N-methylisoleucine, or isoleucine; AA2 is the same or a different amino acid residue as in AA1; and AA3 is alanine or N-methylalanine.
摘要翻译： 已经发现一小部分小肽对TGF-β活性具有抑制作用，优选具有式I的一级结构：其中AA1是亮氨酸，苯丙氨酸，α-氨基异丁酸，N-甲基丙氨酸，N-甲基异亮氨酸或异亮氨酸; AA2是与AA1相同或不同的氨基酸残基; 而AA3是丙氨酸或N-甲基丙氨酸。
-
公开(公告)号：US5780436A
公开(公告)日：1998-07-14
申请号：US742256
申请日：1996-10-31
IPC分类号： A61K47/30 , A61K38/00 , A61K38/22 , A61K47/48 , A61L27/22 , A61P17/02 , A61P25/00 , A61P43/00 , C07K7/06 , C07K14/495 , A61K38/04 , A61K38/08 , C07K5/10
CPC分类号： C07K7/06 , A61L27/227 , C07K14/495 , A61K38/00
摘要： Small peptide mimics of TGF-.beta., having the general sequence AA.sub.i -AA.sub.i+1 -AA.sub.i+2 followed by AA.sub.i+n shortly thereafter, have been prepared. In this sequence, AA.sub.i is alanine, asparagine, or leucine, AA.sub.i+1 is valine or isoleucine, AA.sub.i+2 is alanine, n is 3, 4, or 5 such that there are n-3 amino acid residues in between AA.sub.i+2 and AA.sub.i+n, and AA.sub.i+n is glutamic acid, aspartic acid, glutamine or asparagine. Because the essential requirement for TGF-.beta. activity is the peptide's ability to form a stable .beta.-bend structure under physiologic conditions, the inventive peptides are collectively referred to as .beta.-bend peptides. Compositions for applications such as tissue repair are also provided that comprise a biocompatible matrix having cytomodulin or a cytomodulin analog admixed with or carried by the matrix.
摘要翻译： 已经制备了具有通用序列AAi-AAi + 1-AAi + 2，随后是AAi + n的TGF-β的小肽模拟物。 在该序列中，AAi是丙氨酸，天冬酰胺或亮氨酸，AAi + 1是缬氨酸或异亮氨酸，AAi + 2是丙氨酸，n是3,4或5，使得在AAi + 2之间存在n-3个氨基酸残基 AAi + n，AAi + n为谷氨酸，天冬氨酸，谷氨酰胺或天冬酰胺。 因为TGF-β活性的基本要求是肽在生理条件下形成稳定的β-末端结构的能力，所以本发明的肽统称为β-末端肽。 还提供了诸如组织修复的组合物，其包含具有与基质混合或携带的细胞调节蛋白或细胞模型蛋白类似物的生物相容性基质。
-
公开(公告)号：US06638912B2
公开(公告)日：2003-10-28
申请号：US09113696
申请日：1998-07-10
IPC分类号： A61K3807
CPC分类号： A61L27/227 , A61K38/00 , C07K7/06 , C07K14/495 , C07K14/78
摘要： Compositions suitable for pharmaceutical administration are provided in which one compound is a small peptide mimic of TGF-&bgr;. More preferably, pharmaceutical compositions of the present invention are formulated as combinations of two components, wherein one component includes a peptide mimic for TGF-&bgr; and the other component is structurally or biologically analogous to a small region of collagen and mimics the conformation recognized by collagen binding species. A particularly preferred combination is A-N-V-A-E-N-A (SEQ ID NO:1) and G-T-P-G-P-Q-G-I-A-G-Q-R-G-V-V (SEQ ID NO:17).
摘要翻译： 提供了适合于药物给药的组合物，其中一种化合物是TGF-β的小肽模拟物。 更优选地，将本发明的药物组合物配制成两种组分的组合，其中一种组分包括TGF-β的肽模拟物，另一种组分在结构上或生物学上类似于胶原蛋白的小区域并且模拟胶原识别的构象 结合物种。 特别优选的组合是A-N-V-A-E-N-A（SEQ ID NO：1）和G-T-P-G-P-Q-G-I-A-G-Q-R-G-V-V（SEQ ID NO：17）。
-
公开(公告)号：US5661127A
公开(公告)日：1997-08-26
申请号：US431954
申请日：1995-05-01
CPC分类号： C07K7/06 , A61L27/227 , C07K14/495 , A61K38/00
摘要： A peptide has been synthesized with the sequence ANVAENA (SEQ ID NO:1). This peptide, designated "cytomodulin," is able to mimic a broad range of activities of TGF-.beta.1 in various cell types. Compositions for applications such as tissue repair are provided that comprise a biocompatible matrix having cytomodulin admixed with or carried by the matrix.
摘要翻译： 已经用序列ANVAENA（SEQ ID NO：1）合成肽。 这种称为“细胞模型调节蛋白”的肽能够模拟各种细胞类型中TGF-β1的广泛活性。 提供了诸如组织修复的组合物，其包含与基质混合或由基质携带的细胞调节蛋白的生物相容性基质。
-
5.发明授权AAV vector compositions and methods for enhanced expression of immunoglobulins using the same 失效AAV载体组合物和使用其的增强免疫球蛋白表达的方法公开(公告)号：US07714119B2
公开(公告)日：2010-05-11
申请号：US11179639
申请日：2005-07-13
申请人： Jianmin Fang , Karin Jooss , Jing Jing Qian
发明人： Jianmin Fang , Karin Jooss , Jing Jing Qian
CPC分类号： C12N15/86 , A61K48/00 , C07K16/00 , C07K16/2863 , C07K2317/21 , C07K2317/74 , C12N2750/14132 , C12N2750/14143
摘要： Single AAV vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allowing for expression of a functional antibody molecule using a single promoter. The vector constructs may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo.
摘要翻译： 描述了用于表达免疫球蛋白分子或其片段的单一AAV载体构建体及其制备和使用方法。 AAV载体包含允许使用单一启动子表达功能性抗体分子的第一和第二免疫球蛋白编码序列之间的自加工切割序列。 载体构建体可进一步包括另外的蛋白水解切割序列，其提供从表达的免疫球蛋白分子或其片段中除去自身加工肽序列的手段。 载体构建体在体外和体内发现在生物活性免疫球蛋白或其片段的增强生产中起作用。
-
公开(公告)号：US07632509B2
公开(公告)日：2009-12-15
申请号：US11488568
申请日：2006-07-18
申请人： Jianmin Fang , Karin Jooss , Andrew Simmons , Debbie Farson , Jing Jing Qian
发明人： Jianmin Fang , Karin Jooss , Andrew Simmons , Debbie Farson , Jing Jing Qian
IPC分类号： A61K39/21 , A61K39/38 , A61K39/295 , C12N7/00 , C12N7/02 , C12N15/00 , C07K16/00 , A61K39/395 , A61K39/275
CPC分类号： C12N15/86 , C07K16/2863 , C07K2317/21 , C07K2317/76 , C12N2510/02 , C12N2740/15043
摘要： Lentivector constructs for expression of recombinant proteins, polypeptides or fragments thereof and methods of making the same are described. The lentivectors typically have a self-processing cleavage sequence between a first and second protein or polypeptide coding sequence allowing for expression of a functional protein or polypeptide under operative control of a single promoter and may further include an additional proteolytic cleavage sequence which provides a means to remove the self-processing cleavage sequence from the expressed protein or polypeptide. The vector constructs find utility in methods relating to enhanced production of biologically active proteins, such as immunoglobulins or fragments thereof in vitro and in vivo.
摘要翻译： 描述了用于表达重组蛋白，多肽或其片段的重组体构建体及其制备方法。 扁豆药通常在第一和第二蛋白质或多肽编码序列之间具有允许在单个启动子的操作控制下表达功能性蛋白质或多肽的自加工切割序列，并且还可以包括额外的蛋白水解切割序列， 从表达的蛋白质或多肽中除去自处理切割序列。 载体构建体在体外和体内在生物活性蛋白质如免疫球蛋白或其片段增强生产相关的方法中发挥作用。
-
7.发明申请AAV VECTOR COMPOSITIONS AND METHODS FOR ENHANCED EXPRESSION OF IMMUNOGLOBULINS USING THE SAME 审中-公开AAV载体组合物和使用其增强免疫球蛋白表达的方法公开(公告)号：US20110065779A1
公开(公告)日：2011-03-17
申请号：US12718069
申请日：2010-03-05
申请人： Jianmin Fang , Karin Jooss , Jing Jing Qian
发明人： Jianmin Fang , Karin Jooss , Jing Jing Qian
CPC分类号： C12N15/86 , A61K48/00 , C07K16/00 , C07K16/2863 , C07K2317/21 , C07K2317/74 , C12N2750/14132 , C12N2750/14143
摘要： Single AAV vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allowing for expression of a functional antibody molecule using a single promoter. The vector constructs may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo.
摘要翻译： 描述了用于表达免疫球蛋白分子或其片段的单一AAV载体构建体及其制备和使用方法。 AAV载体包含允许使用单一启动子表达功能性抗体分子的第一和第二免疫球蛋白编码序列之间的自加工切割序列。 载体构建体可进一步包括另外的蛋白水解切割序列，其提供从表达的免疫球蛋白分子或其片段中除去自身加工肽序列的手段。 载体构建体在体外和体内发现在生物活性免疫球蛋白或其片段的增强生产中起作用。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.022 秒)