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    Methods to express recombinant proteins from lentiviral vectors
    1.
    发明授权
    Methods to express recombinant proteins from lentiviral vectors 失效
    从慢病毒载体表达重组蛋白的方法

    公开(公告)号：US07632509B2

    公开(公告)日：2009-12-15

    申请号：US11488568

    申请日：2006-07-18

    申请人： Jianmin Fang ,  Karin Jooss ,  Andrew Simmons ,  Debbie Farson ,  Jing Jing Qian

    发明人： Jianmin Fang ,  Karin Jooss ,  Andrew Simmons ,  Debbie Farson ,  Jing Jing Qian

    IPC分类号： A61K39/21 ,  A61K39/38 ,  A61K39/295 ,  C12N7/00 ,  C12N7/02 ,  C12N15/00 ,  C07K16/00 ,  A61K39/395 ,  A61K39/275

    CPC分类号： C12N15/86 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/76 ,  C12N2510/02 ,  C12N2740/15043

    摘要： Lentivector constructs for expression of recombinant proteins, polypeptides or fragments thereof and methods of making the same are described. The lentivectors typically have a self-processing cleavage sequence between a first and second protein or polypeptide coding sequence allowing for expression of a functional protein or polypeptide under operative control of a single promoter and may further include an additional proteolytic cleavage sequence which provides a means to remove the self-processing cleavage sequence from the expressed protein or polypeptide. The vector constructs find utility in methods relating to enhanced production of biologically active proteins, such as immunoglobulins or fragments thereof in vitro and in vivo.

    摘要翻译： 描述了用于表达重组蛋白，多肽或其片段的重组体构建体及其制备方法。 扁豆药通常在第一和第二蛋白质或多肽编码序列之间具有允许在单个启动子的操作控制下表达功能性蛋白质或多肽的自加工切割序列，并且还可以包括额外的蛋白水解切割序列， 从表达的蛋白质或多肽中除去自处理切割序列。 载体构建体在体外和体内在生物活性蛋白质如免疫球蛋白或其片段增强生产相关的方法中发挥作用。

    Methods to express recombinant proteins from lentiviral vectors
    7.
    发明申请
    Methods to express recombinant proteins from lentiviral vectors 失效
    从慢病毒载体表达重组蛋白的方法

    公开(公告)号：US20070059820A1

    公开(公告)日：2007-03-15

    申请号：US11488568

    申请日：2006-07-18

    申请人： Jianmin Fang ,  Karin Jooss ,  Andrew Simmons ,  Debbie Farson

    发明人： Jianmin Fang ,  Karin Jooss ,  Andrew Simmons ,  Debbie Farson

    IPC分类号： C12Q1/68 ,  C12N15/00

    CPC分类号： C12N15/86 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/76 ,  C12N2510/02 ,  C12N2740/15043

    摘要： Lentivector constructs for expression of recombinant proteins, polypeptides or fragments thereof and methods of making the same are described. The lentivectors typically have a self-processing cleavage sequence between a first and second protein or polypeptide coding sequence allowing for expression of a functional protein or polypeptide under operative control of a single promoter and may further include an additional proteolytic cleavage sequence which provides a means to remove the self-processing cleavage sequence from the expressed protein or polypeptide. The vector constructs find utility in methods relating to enhanced production of biologically active proteins, such as immunoglobulins or fragments thereof in vitro and in vivo.

    摘要翻译： 描述了用于表达重组蛋白，多肽或其片段的重组体构建体及其制备方法。 扁豆药通常在第一和第二蛋白质或多肽编码序列之间具有允许在单个启动子的操作控制下表达功能性蛋白质或多肽的自加工切割序列，并且还可以包括额外的蛋白水解切割序列， 从表达的蛋白质或多肽中除去自处理切割序列。 载体构建体在体外和体内在生物活性蛋白质如免疫球蛋白或其片段增强生产相关的方法中发挥作用。

    METHODS TO EXPRESS RECOMBINANT PROTEINS FROM LENTIVIRAL VECTORS
    8.
    发明申请
    METHODS TO EXPRESS RECOMBINANT PROTEINS FROM LENTIVIRAL VECTORS 审中-公开
    从嗜酸性载体表达重组蛋白的方法

    公开(公告)号：US20110028694A1

    公开(公告)日：2011-02-03

    申请号：US12612405

    申请日：2009-11-04

    申请人： Jianmin Fang ,  Karin Jooss ,  Andrew Simmons ,  Debbie Farson

    发明人： Jianmin Fang ,  Karin Jooss ,  Andrew Simmons ,  Debbie Farson

    IPC分类号： C07K16/00 ,  C12N15/63 ,  C12N5/10

    CPC分类号： C12N15/86 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/76 ,  C12N2510/02 ,  C12N2740/15043

    摘要： Lentivector constructs for expression of recombinant proteins, polypeptides or fragments thereof and methods of making the same are described. The lentivectors typically have a self-processing cleavage sequence between a first and second protein or polypeptide coding sequence allowing for expression of a functional protein or polypeptide under operative control of a single promoter and may further include an additional proteolytic cleavage sequence which provides a means to remove the self-processing cleavage sequence from the expressed protein or polypeptide. The vector constructs find utility in methods relating to enhanced production of biologically active proteins, such as immunoglobulins or fragments thereof in vitro and in vivo.

    摘要翻译： 描述了用于表达重组蛋白，多肽或其片段的重组体构建体及其制备方法。 扁豆药通常在第一和第二蛋白质或多肽编码序列之间具有允许在单个启动子的操作控制下表达功能性蛋白质或多肽的自加工切割序列，并且还可以包括额外的蛋白水解切割序列， 从表达的蛋白质或多肽中除去自处理切割序列。 载体构建体在体外和体内在生物活性蛋白质如免疫球蛋白或其片段增强生产相关的方法中发挥作用。