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公开(公告)号：US20100204208A1
公开(公告)日：2010-08-12
申请号：US12691607
申请日：2010-01-21
申请人： Rajinder Singh , Hui Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
发明人： Rajinder Singh , Hui Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
IPC分类号： A61K31/55 , C07D401/14 , A61K31/496 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D403/14 , A61P1/00 , A61P27/02 , A61P37/00 , A61P29/00 , A61P17/06 , A61P25/28 , C12Q1/48
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US20100184755A1
公开(公告)日：2010-07-22
申请号：US12687054
申请日：2010-01-13
申请人： Haoran Zhao , Rao Kolluri , Carlos Valdez , Kin Tso , Rajinder Singh , John Ramphal
发明人： Haoran Zhao , Rao Kolluri , Carlos Valdez , Kin Tso , Rajinder Singh , John Ramphal
IPC分类号： A61K31/5383 , C07D498/04 , C07D498/10 , A61P37/00 , A61P29/00 , A61P27/02 , C12N9/99
CPC分类号： C07D498/04 , A61K31/5383 , C07D498/14
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本公开涉及可用作蛋白激酶C（PKC）的抑制剂的化合物，因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08394951B2
公开(公告)日：2013-03-12
申请号：US12687054
申请日：2010-01-13
申请人： Haoran Zhao , Rao Kolluri , Carlos Valdez , Kin Tso , Rajinder Singh , John Ramphal
发明人： Haoran Zhao , Rao Kolluri , Carlos Valdez , Kin Tso , Rajinder Singh , John Ramphal
IPC分类号： C07D345/00 , C07D517/00
CPC分类号： C07D498/04 , A61K31/5383 , C07D498/14
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US08377924B2
公开(公告)日：2013-02-19
申请号：US12691607
申请日：2010-01-21
申请人： Rajinder Singh , Huí Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
发明人： Rajinder Singh , Huí Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
IPC分类号： A61K31/55 , A61K31/497 , A61K31/535 , A61K31/505 , C07D403/10 , C07D413/12 , C07D401/12
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US20100130486A1
公开(公告)日：2010-05-27
申请号：US12175441
申请日：2008-07-17
申请人： Rajinder Singh , Hui Li , Haoran Zhao , Donald Payan , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu
发明人： Rajinder Singh , Hui Li , Haoran Zhao , Donald Payan , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu
IPC分类号： A61K31/5383 , C07D401/14 , C07D403/14 , C07D265/38 , C07D413/14 , A61K31/497 , A61K31/506 , A61K31/5377 , A61P35/00
CPC分类号： C07D401/12 , C07D239/48 , C07D401/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D498/04
摘要： The invention encompasses compounds having formula I or II and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is therapeutically useful.
摘要翻译： 本发明包括具有式I或II的化合物以及使用这些化合物治疗PKC和PKD的抑制在治疗上有用的条件的组合物和方法。
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公开(公告)号：US08993585B2
公开(公告)日：2015-03-31
申请号：US12175441
申请日：2008-07-17
申请人： Rajinder Singh , Hui Li , Haoran Zhao , Donald Payan , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu
发明人： Rajinder Singh , Hui Li , Haoran Zhao , Donald Payan , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu
IPC分类号： C07D401/12 , C07D239/48 , C07D401/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D498/04
CPC分类号： C07D401/12 , C07D239/48 , C07D401/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D498/04
摘要： The invention encompasses compounds having formula I or II and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is therapeutically useful.
摘要翻译： 本发明包括具有式I或II的化合物以及使用这些化合物治疗PKC和PKD的抑制在治疗上有用的条件的组合物和方法。
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公开(公告)号：US20110130415A1
公开(公告)日：2011-06-02
申请号：US12958284
申请日：2010-12-01
申请人： Rajinder Singh , Kin Tso , Jing Zhang , Matthew Duncton , Salvador Alvarez , Rao Kolluri , John Ramphal , Sacha Holland
发明人： Rajinder Singh , Kin Tso , Jing Zhang , Matthew Duncton , Salvador Alvarez , Rao Kolluri , John Ramphal , Sacha Holland
IPC分类号： A61K31/506 , C07D401/14 , C07D405/14 , A61P29/00 , A61P17/00 , A61P17/06 , A61P37/08 , A61P1/16 , A61P11/00 , A61P9/10 , A61P25/00 , A61P31/18 , A61P9/12 , A61P3/04 , A61P37/06 , C12N9/99 , C12Q1/48
CPC分类号： C07D405/14 , A61K31/41 , A61K31/506 , C07D401/14
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本公开涉及可用作蛋白激酶C（PKC）的抑制剂的化合物，因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08299087B2
公开(公告)日：2012-10-30
申请号：US12902052
申请日：2010-10-11
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US20080260754A1
公开(公告)日：2008-10-23
申请号：US12053438
申请日：2008-03-21
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K39/395 , C12N9/12 , C07D239/24 , A61K31/505 , C07D295/00 , A61K31/5377 , C07D498/02 , C12N5/00 , A61P37/00 , A61K31/5383 , C07D403/02 , A61K31/496 , C07D279/16 , A61K31/5415 , A61K38/13
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US20110027856A1
公开(公告)日：2011-02-03
申请号：US12902052
申请日：2010-10-11
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： C12N9/99
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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