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公开(公告)号：US5396897A
公开(公告)日：1995-03-14
申请号：US058682
申请日：1993-05-03
CPC分类号： A61B5/03 , A61B2090/3904
摘要： A method for locating a lesion within a tissue mass, includes steps of measuring a selected parameter at two or more points in at least one path through the tissue mass, the measure of the selected parameter in a lesion being different from that in normal tissue. Also, apparatus for measuring a tissue parameter at two or more points in at least one path through the tissue mass includes an insertion needle, distally sharpened and made sufficiently rigid so that it can be inserted distal end foremost into the tissue mass along the path, and, insertible with the needle, a sensor capable of prodding a measure of the tissue parameter at a point in the tissue mass along the path. Where the parameter is selected as one that has a measure different in a lesion type, the apparatus can be used in carrying out the method, whereby a measure at a point in the tissue mass of the selected tissue parameter provided by the sensor indicates that the point is within a lesion. In an embodiment for measuring interstitial fluid pressure in the tissue mass, the sensor includes a tube slidably engageable within the lumen of the insertion needle; the sensor tube is closed at a distal end, and the walls of the sensor tube and the insertion needle are prodded distally with ports, positioned in relation to the respective distal ends such that when the sensor tube is engaged within the insertion tube lumen the ports can be substantially aligned to provide fluid communication between the lumen of the sensor tube and the tissue adjacent the ports; the sensor tube lumen contains a plurality of filaments, and is operationally connected to a pressure measurement deuce such that the pressure measurement deuce is responsive to fluid pressure within the sensor tube lumen.
摘要翻译： 一种用于定位组织块内的损伤的方法，包括以下步骤：在至少一个穿过组织块的路径中的两个或多个点处测量所选择的参数，所述病变中所选参数的测量与正常组织中的不同。 此外，在穿过组织块的至少一条路径中的两个或更多个点处测量组织参数的装置包括：远端切削并制成足够刚性的插入针，使得其可以沿着路径最前端插入组织块， 并且能够与针一起插入能够沿着路径刺激组织块中的一点处的组织参数的测量的传感器。 如果参数被选择为具有在病变类型中不同的度量的参数，则可以使用该装置来执行该方法，由此由传感器提供的所选择的组织参数的组织块中的点处的度量指示： 点在病变内。 在用于测量组织块中的组织液压的实施例中，传感器包括可滑动地接合在插入针的内腔内的管; 传感器管在远端封闭，并且传感器管和插入针的壁通过端口向远端方向延伸，其位置相对于相应的远端，使得当传感器管接合在插入管腔内时，端口 可以基本上对准以提供传感器管的内腔和邻近端口的组织之间的流体连通; 传感器管腔包含多个细丝，并且可操作地连接到压力测量装置，使得压力测量装置响应于传感器管腔内的流体压力。
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公开(公告)号：US07356113B2
公开(公告)日：2008-04-08
申请号：US10776690
申请日：2004-02-11
申请人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel B. Kopans , Richard Moore
发明人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel B. Kopans , Richard Moore
IPC分类号： A61B6/02
CPC分类号： G06T11/006 , A61B6/025 , A61B6/502 , A61B6/583 , G01N23/04 , G06T2211/424 , G06T2211/436
摘要： A system for three-dimensional tomosynthesis imaging of a target element includes an image acquisition element and a processor. The image acquisition element obtains a plurality of images of the target element from a plurality of angles and includes a radiation source that is positionable at a plurality of angles with respect to the target element and a radiation detector. The radiation detector is positioned so as to detect radiation emitted by the radiation source passing through the target element and determine a plurality of attenuation values for radiation passing through the target element to establish a radiation absorbance projection image of the target element for a particular radiation source angle. The processor is configured to apply an iterative reconstruction algorithm to the radiation absorbance projection images of the target element obtained from a plurality of radiation source angles to generate a three-dimensional reconstruction of the target element.
摘要翻译： 用于目标元件的三维断层合成成像的系统包括图像采集元件和处理器。 图像采集元件从多个角度获得目标元件的多个图像，并且包括可相对于目标元件以多个角度定位的辐射源和放射线检测器。 放射线检测器被定位成检测通过目标元件的辐射源发射的辐射，并确定用于通过目标元件的辐射的多个衰减值，以建立用于特定辐射源的目标元件的辐射吸收投影图像 角度。 处理器被配置为对从多个辐射源角度获得的目标元件的辐射吸收投影图像应用迭代重建算法，以产生目标元素的三维重建。
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公开(公告)号：US20080232545A1
公开(公告)日：2008-09-25
申请号：US12099416
申请日：2008-04-08
申请人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel B. Kopans , Richard Moore
发明人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel B. Kopans , Richard Moore
IPC分类号： A61B6/00
CPC分类号： G06T11/006 , A61B6/025 , A61B6/502 , A61B6/583 , G01N23/04 , G06T2211/424 , G06T2211/436
摘要： A system for three-dimensional tomosynthesis imaging of a target element is provided having an image acquisition element and a processor. The image acquisition element obtains a plurality of images of the target element from a plurality of angles and includes a radiation source that is positionable at a plurality of angles with respect to the target element and a radiation detector. The radiation detector is positioned so as to detect radiation emitted by the radiation source passing through the target element and determine a plurality of attenuation values for radiation passing through the target element to establish a radiation absorbance projection image of the target element for a particular radiation source angle. The processor is configured to apply an iterative reconstruction algorithm to the radiation absorbance projection images of the target element obtained from a plurality of radiation source angles to generate a three-dimensional reconstruction of the target element. The system can gain further accuracy where the iterative reconstruction algorithm is applied using cone-beam forward projection and back projection.
摘要翻译： 提供了具有图像采集元件和处理器的目标元件的三维断层合成成像系统。 图像采集元件从多个角度获得目标元件的多个图像，并且包括可相对于目标元件以多个角度定位的辐射源和放射线检测器。 放射线检测器被定位成检测通过目标元件的辐射源发射的辐射，并确定通过目标元件的辐射的多个衰减值，以建立用于特定辐射源的目标元件的辐射吸收投影图像 角度。 处理器被配置为对从多个辐射源角度获得的目标元件的辐射吸收投影图像应用迭代重建算法，以产生目标元素的三维重建。 在使用锥束前向投影和反投影应用迭代重建算法的情况下，系统可以获得进一步的准确性。
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公开(公告)号：US5553111A
公开(公告)日：1996-09-03
申请号：US329295
申请日：1994-10-26
申请人： Richard Moore , Daniel B. Kopans
发明人： Richard Moore , Daniel B. Kopans
CPC分类号： A61B6/502 , A61B6/0414
摘要： An improved tissue imaging system is provided, in which tissue can be sheared without direct manual manipulation, so that different perspective images of the tissue can be determined, preferably in a single compression cycle. In one aspect of the invention, a traction system is provided, comprising at least a layer of a radiolucent material dimensioned and constructed such that the layer can pass between tissue and a surface of a tissue imaging device. The radiolucent material has sufficient tensile strength that the layer can slide without tearing against the surface of the tissue imaging device when tension is exerted on the layer, the sliding resulting in movement of the tissue relative to the surface of the tissue imaging device. A method of moving tissue relative to at least one surface of a tissue imaging device is also provided.
摘要翻译： 提供了一种改进的组织成像系统，其中组织可以被剪切而没有直接的手动操作，使得组织的不同透视图可优选地在单个压缩循环中被确定。 在本发明的一个方面，提供了一种牵引系统，其包括至少一层辐射可透过材料，其尺寸和构造使得该层可以在组织和组织成像装置的表面之间通过。 射线可透过材料具有足够的拉伸强度，当张力施加在层上时，该层可以滑动而不会撕裂到组织成像装置的表面，因此滑动导致组织相对于组织成像装置的表面移动。 还提供了相对于组织成像装置的至少一个表面移动组织的方法。
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公开(公告)号：US5506877A
公开(公告)日：1996-04-09
申请号：US344284
申请日：1994-11-23
CPC分类号： A61B6/502
摘要： A breast compression device is disclosed for use in a mammography system. A paddle support frame is provided which is slidably connected to a system arm of the mammography system. The paddle support frame is located between the x-ray tube and the detector of the mammography system. A compression paddle is pivotally connected within the support frame by a pivot connection. The pivot connection is located on a chest wall side of the support frame. The chest wall side is opposite the system arm. The compression paddle is substantially horizontal to the detector and is rotatable around the pivot connection. The compression paddle may include a breast portion which is substantially parallel to the detector and a chest wall portion which is substantially vertical to the detector. The compression paddle may also have a contoured shape where the chest wall portion is angled away from the system arm and the breast portion is contoured to mimic the contours of the breast.
摘要翻译： 公开了用于乳房X线照相术系统的乳房压缩装置。 提供了桨式支撑框架，其可滑动地连接到乳房X射线摄影系统的系统臂。 桨支撑框架位于X射线管和乳腺摄影系统的检测器之间。 压缩桨叶通过枢转连接枢转地连接在支撑框架内。 枢轴连接位于支撑框架的胸壁侧。 胸壁侧与系统臂相对。 压缩桨叶基本上与检测器水平，并且可围绕枢转连接件旋转。 压缩桨可以包括基本上平行于检测器的乳房部分和基本垂直于检测器的胸壁部分。 压缩桨也可以具有轮廓形状，其中胸壁部分远离系统臂成角度，并且乳房部分被轮廓化以模拟乳房的轮廓。
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公开(公告)号：US5872828A
公开(公告)日：1999-02-16
申请号：US898058
申请日：1997-07-22
CPC分类号： A61B6/502 , A61B6/025 , A61B6/4233 , G06T11/006 , G06T2211/436
摘要： The invention includes both systems and methods for tomosynthesis x-ray imaging. An x-ray source is moved at various positions in an arc around an object, e.g., a breast, to illuminate a stationary digital detector (or its equivalent) placed at an image plane behind the object. A digital image data processor collects data from the detector and a motion controller moves the source around the object. As the source moves along the arc, the detector generates, for a succession of points along the arc, a corresponding succession of image data sets, each set being representative of the intensity of x-rays incident on the detector for the then current position of the source. The image data processor is responsive to the image data sets to generate an output image signal representative of the x-ray absorption of points within the object region. The processor transforms the image plane data to a form corresponding to that which would have been generated had the x-ray source moved in a linear motion in a source plane parallel to the image plane, rather than an arc. The resultant image data thus corresponds in form to that produced by a conventional linear motion, e.g., Twinning-type, system, so that conventional techniques and equipment may be used to produce a final representation of the x-ray absorption of the object region.
摘要翻译： 本发明包括用于层析合成X射线成像的系统和方法。 X射线源在围绕物体（例如乳房）的弧中的各个位置移动，以照亮放置在物体后面的图像平面上的固定数字检测器（或其等效物）。 数字图像数据处理器从检测器收集数据，并且运动控制器围绕物体移动源。 当源沿着弧线移动时，检测器对于沿着弧的一系列点产生对应的连续的图像数据集，每组都代表入射在检测器上的X射线的强度，用于当前的位置 来源。 图像数据处理器响应于图像数据组以产生表示对象区域内的点的x射线吸收的输出图像信号。 处理器将图像平面数据转换成与X射线源平行于图像平面的源平面中的线性运动而不是弧形而产生的图像平面数据相对应的形式。 所得到的图像数据因此对应于通过常规线性运动产生的图像数据，例如，Twinning型系统，使得常规技术和设备可以用于产生对象区域的x射线吸收的最终表示。
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公开(公告)号：US4962515A
公开(公告)日：1990-10-09
申请号：US435613
申请日：1989-11-13
申请人： Daniel B. Kopans
发明人： Daniel B. Kopans
IPC分类号： A61B6/00
CPC分类号： A61B6/502
摘要： Disclosed is a breast compression assembly for an mammography apparatus and a breast compression plate for use in such apparatus. The assembly includes a first compression plate having a first compression surface extending from an input edge thereof and a second compression plate having a second compression surface extending from an input edge thereof. At least one of the compression plates includes an associated ridge member affixed to its input edge. The ridge member extends beyond the surface of the associated compression plate in the direction substantially perpendicular to the compression surface of the plate. The device further includes means for positioning the first and second compression plates, and means for selectively controlling the separation between the compression surfaces of the plates along a reference axis substantially perpendicular to the compression surfaces of the plates.
摘要翻译： 公开了一种用于乳房X线摄影装置的乳房压缩组件和用于这种装置中的乳房压缩板。 组件包括具有从其输入边缘延伸的第一压缩表面的第一压缩板和具有从其输入边缘延伸的第二压缩表面的第二压缩板。 压缩板中的至少一个包括固定到其输入边缘的相关联的隆起部件。 脊构件在基本上垂直于板的压缩表面的方向上延伸超过相关联的压缩板的表面。 该装置还包括用于定位第一和第二压缩板的装置，以及用于沿基本上垂直于板的压缩表面的参考轴选择性地控制板的压缩表面之间的间隔的装置。
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8.发明授权Multi-threshold peripheral equalization method and apparatus for digital mammography and breast tomosynthesis 有权多阈值外围均衡方法和数字乳腺X线照相术和乳房断层合成术的装置公开(公告)号：US07764820B2
公开(公告)日：2010-07-27
申请号：US11466518
申请日：2006-08-23
申请人： Tao Wu , Richard H. Moore , Daniel B. Kopans
发明人： Tao Wu , Richard H. Moore , Daniel B. Kopans
CPC分类号： G06T5/007 , G06T5/10 , G06T7/11 , G06T7/136 , G06T2207/10112 , G06T2207/20012 , G06T2207/20056 , G06T2207/20216 , G06T2207/30068
摘要： A peripheral equalization (PE) method and apparatus for compensating for thickness reduction in outer edges of the breast in a mammogram (i.e. a two-dimensional image) while keeping the central area substantially unchanged. The PE method and apparatus can also be applied to three dimensional (tomosynthesis) images of a breast. The peripheral equalization is achieved by segmenting the image of the breast into at least two regions and using a multi-threshold technique to process the data in at least one of the two regions.
摘要翻译： 一种外围均衡（PE）方法和装置，用于在保持中心区域基本上不变的情况下补偿乳房X线照片（即，二维图像）中乳房外缘的厚度减小。 PE方法和装置也可以应用于乳房的三维（断层合成）图像。 通过将乳房的图像分割成至少两个区域并使用多阈值技术来处理两个区域中的至少一个中的数据来实现外围均衡。
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公开(公告)号：US20080285712A1
公开(公告)日：2008-11-20
申请号：US12090314
申请日：2006-10-04
申请人： Daniel B. Kopans , Richard H. Moore
发明人： Daniel B. Kopans , Richard H. Moore
CPC分类号： A61B6/025 , A61B6/027 , A61B6/4233 , A61B6/4291 , A61B6/466 , A61B6/502 , A61B6/5223 , A61B6/588 , A61B6/589
摘要： An imaging method and apparatus is described in which distances between a source and an object are changed and projection images are generated at each of the different distances.
摘要翻译： 描述了一种成像方法和装置，其中源和对象之间的距离改变，并且在每个不同距离处生成投影图像。
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公开(公告)号：US07885378B2
公开(公告)日：2011-02-08
申请号：US12090314
申请日：2006-10-04
申请人： Daniel B. Kopans , Richard H. Moore
发明人： Daniel B. Kopans , Richard H. Moore
CPC分类号： A61B6/025 , A61B6/027 , A61B6/4233 , A61B6/4291 , A61B6/466 , A61B6/502 , A61B6/5223 , A61B6/588 , A61B6/589
摘要： An imaging method and apparatus is described in which distances between a source and an object are changed and projection images are generated at each of the different distances.
摘要翻译： 描述了一种成像方法和装置，其中源和对象之间的距离改变，并且在每个不同距离处生成投影图像。
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