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1.发明授权公开(公告)号：US08282943B2
公开(公告)日：2012-10-09
申请号：US11921421
申请日：2006-05-31
IPC分类号： A61K39/385 , A01N63/02
CPC分类号： C07K14/51 , A61K39/0011 , A61K2039/523 , C07K16/24 , C07K16/30 , C07K2317/23 , Y02A50/478
摘要： The invention is relates to drugs on the basis of antibodies against non-cellular bone matrix proteins, especially BSP, for use in the prevention and treatment of bone metastases. According to the invention, the antibodies are induced in the patient by recombinantly expressing antigenic determinants of bone matrix proteins in Listeria and anchoring them on the surfaces thereof. The antigenic determinants are selected according to whether they are characteristic of antigens that are expressed by the tumor cells themselves.
摘要翻译： 本发明涉及基于针对用于预防和治疗骨转移的非细胞骨基质蛋白，特别是BSP的抗体的药物。 根据本发明，通过在利斯特氏菌中重组表达骨基质蛋白的抗原决定簇并将其锚定在其表面上，在患者体内诱导抗体。 根据它们是否由肿瘤细胞本身表达的抗原的特征来选择抗原决定簇。
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2.发明申请公开(公告)号：US20090142372A1
公开(公告)日：2009-06-04
申请号：US11921421
申请日：2006-05-31
CPC分类号： C07K14/51 , A61K39/0011 , A61K2039/523 , C07K16/24 , C07K16/30 , C07K2317/23 , Y02A50/478
摘要： The invention is relates to drugs on the basis of antibodies against non-cellular bone matrix proteins, especially BSP, for use in the prevention and treatment of bone metastases. According to the invention, the antibodies are induced in the patient by recombinantly expressing antigenic determinants of bone matrix proteins in Listeria and anchoring them on the surfaces thereof. The antigenic determinants are selected according to whether they are characteristic of antigens that are expressed by the tumor cells themselves.
摘要翻译： 本发明涉及基于针对用于预防和治疗骨转移的非细胞骨基质蛋白，特别是BSP的抗体的药物。 根据本发明，通过在利斯特氏菌中重组表达骨基质蛋白的抗原决定簇并将其锚定在其表面上，在患者体内诱导抗体。 根据它们是否由肿瘤细胞本身表达的抗原的特征来选择抗原决定簇。
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3.发明申请公开(公告)号：US20090220517A1
公开(公告)日：2009-09-03
申请号：US12162804
申请日：2006-11-29
CPC分类号： C07K14/37 , A61K39/00 , A61K2039/523 , C07K14/4748 , C12N15/74
摘要： The present invention relates to a method for producing carrier microorganisms, in particular bacteria, which, through targeted genetic manipulation, carry epitopes or epitomers, respectively, on their surfaces. Epitomers are antigenically effective epitopes that can be found in the polypeptide chain in multiple identical copies, and which, when expressed on the surface of the bacteria, can be used for immunization with particular success. A further aspect relates to correspondingly produced bacteria and their uses as vaccines, in particular in cancer therapy.
摘要翻译： 本发明涉及一种用于生产载体微生物，特别是细菌的方法，其通过目标遗传操作分别在其表面上携带表位或表位。 表面活性剂是抗原有效的表位，其可以在多个相同的拷贝中在多肽链中发现，并且当在细菌表面上表达时，可以特别成功地用于免疫。 另一方面涉及相应产生的细菌及其作为疫苗的用途，特别是在癌症治疗中。
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4.发明授权Method for the detection and identification of a variant C. difficile strain in a sample 有权用于检测和鉴定样品中艰难梭菌菌株变体的方法公开(公告)号：US08889363B2
公开(公告)日：2014-11-18
申请号：US12510013
申请日：2009-07-27
IPC分类号： G01N33/53 , G01N33/569 , C07K16/12
CPC分类号： G01N33/56911 , C07K16/1282
摘要： The method for detecting and identifying a variant C. difficile strain in a sample is characterized by the following steps: (a) obtaining a sample of excreta or tissue from a human or animal patient body; (b) bringing the sample into contact with at least one antibody from each of at least three of the antibody groups group I, group II, group III, group IV, group V and group VI; (c) detecting the antibody reaction and constructing the reaction pattern; (d) comparing the reaction pattern obtained in (c) with reference patterns from known C. difficile strains and C. difficile strains the presence of which is to be tested in the investigation test; (e) assessing the agreement between the reaction pattern obtained in (c) and the reference pattern as indicative of the presence of the C. difficile strain of the reference pattern concerned in the sample.
摘要翻译： 用于检测和鉴定样品中艰难梭菌菌株的方法的特征在于以下步骤：（a）从人或动物患者体内获得排泄物或组织的样品; （b）使样品与至少三种抗体组I，II组，III组，IV组，V组和VI组中的至少一种抗体接触; （c）检测抗体反应并构建反应图; （d）将在（c）中获得的反应模式与来自已知艰难梭菌菌株和艰难梭菌菌株的参考样式进行比较，其中有待测试在调查试验中; （e）评估在（c）中获得的反应模式与参考模式之间的一致性，指示样品中涉及的参考图谱的艰难梭菌菌株的存在。
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