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    Method for the Delivery of Exogenous Antigens into the Mhc Class I Presentation Pathway of Cells
    4.
    发明申请
    Method for the Delivery of Exogenous Antigens into the Mhc Class I Presentation Pathway of Cells 审中-公开
    将外源性抗原递送入细胞的Mhc I类介绍途径的方法

    公开(公告)号：US20080254046A1

    公开(公告)日：2008-10-16

    申请号：US11910111

    申请日：2006-04-07

    申请人： Christoph von Eichel-Streiber ,  Karina Gisch

    发明人： Christoph von Eichel-Streiber ,  Karina Gisch

    IPC分类号： A61K39/00 ,  C12Q1/02 ,  A61P37/00 ,  C12Q1/60

    CPC分类号： A61K39/00 ,  A61K2039/5154 ,  C12N5/0639 ,  C12N2501/70

    摘要： The present invention relates to an in vitro method that allows for delivery of exogenous antigens into the MHC class I presentation pathway of antigen-presenting cells (APCs), comprising the following steps: (a) preparation of suitable APCs; (b) determination of suitable specific method parameters for APCs, comprising (1) bringing the cells in contact with a haemolysin such as listeriolysin (LLO) and a marker substance; (2) measuring of marker substance inflow into the cells; and (3) optionally, modifying said specific parameters; and (c) delivery of exogenous antigens into the APCs, by applying the specific parameters calculated in step (b) and bringing the cells in contact with a haemolysin and the antigen of interest.

    摘要翻译： 本发明涉及允许将外源抗原递送到抗原呈递细胞（APC）的MHC I类呈递途径中的体外方法，其包括以下步骤：（a）制备合适的APC; （b）确定APC的合适的特异性方法参数，包括（1）使细胞与溶血素例如李斯特里菌素（LLO）和标记物质接触; （2）测量进入细胞的标记物质流入; 和（3）任选地修改所述具体参数; 和（c）通过应用步骤（b）中计算的特定参数并使细胞与溶血素和感兴趣的抗原接触，将外源抗原递送到APC中。

    Recombinant listeria
    5.
    发明授权
    Recombinant listeria 失效
    重组李斯特菌

    公开(公告)号：US06825028B1

    公开(公告)日：2004-11-30

    申请号：US09581005

    申请日：2000-06-06

    申请人： Christoph Von Eichel-Streiber ,  Trinad Chakraborty

    发明人： Christoph Von Eichel-Streiber ,  Trinad Chakraborty

    IPC分类号： C12N120

    CPC分类号： C12N15/85 ,  A61K48/00 ,  A61K48/0008 ,  A61K2039/522 ,  A61K2039/523 ,  C12N15/87

    摘要： Disclosed is a TGC method for inducting targeted somatic transgenesis in an animal host, whereby bacteria with a foreign DNA integrated into an episomal vector release, under the control of eukaryotic regulatory elements for ulterior transcription and expression, said foreign DNA in the case of infection of a foreign organism, organ, tissue, cell line or individual cells, causing transcription and expression of foreign DNA and/or foreign protein in said location.

    摘要翻译： 公开了用于在动物宿主中诱导靶向体细胞转位的TGC方法，其中外源DNA整合到附加型载体释放中的细菌在真核调节元件的控制下用于不规则转录和表达，在外源DNA在感染的情况下 外来生物，器官，组织，细胞系或个体细胞，在所述位置引起外源DNA和/或外源蛋白质的转录和表达。

    METHOD FOR THE DETECTION AND IDENTIFICATION OF A VARIANT C. DIFFICILE STRAIN IN A SAMPLE
    6.
    发明申请
    METHOD FOR THE DETECTION AND IDENTIFICATION OF A VARIANT C. DIFFICILE STRAIN IN A SAMPLE 有权
    用于检测和鉴定样品中变体C.差异菌株的方法

    公开(公告)号：US20110020845A1

    公开(公告)日：2011-01-27

    申请号：US12510013

    申请日：2009-07-27

    申请人： Veit BRAUN ,  Karina GISCH ,  Michael Moos ,  Christoph von Eichel-Streiber

    发明人： Veit BRAUN ,  Karina GISCH ,  Michael Moos ,  Christoph von Eichel-Streiber

    IPC分类号： G01N33/569 ,  C07K16/12

    CPC分类号： G01N33/56911 ,  C07K16/1282

    摘要： The method for detecting and identifying a variant C. difficile strain in a sample is characterized by the following steps: (a) obtaining a sample of excreta or tissue from a human or animal patient body; (b) bringing the sample into contact with at least one antibody from each of at least three of the antibody groups group I, group II, group III, group IV, group V and group VI; (c) detecting the antibody reaction and constructing the reaction pattern; (d) comparing the reaction pattern obtained in (c) with reference patterns from known C. difficile strains and C. difficile strains the presence of which is to be tested in the investigation test; (e) assessing the agreement between the reaction pattern obtained in (c) and the reference pattern as indicative of the presence of the C. difficile strain of the reference pattern concerned in the sample.

    摘要翻译： 用于检测和鉴定样品中艰难梭菌菌株的方法的特征在于以下步骤：（a）从人或动物患者体内获得排泄物或组织的样品; （b）使样品与至少三种抗体组I，II组，III组，IV组，V组和VI组中的至少一种抗体接触; （c）检测抗体反应并构建反应图; （d）将在（c）中获得的反应模式与来自已知艰难梭菌菌株和艰难梭菌菌株的参考样式进行比较，其中有待测试在调查试验中; （e）评估在（c）中获得的反应模式与参考模式之间的一致性，指示样品中涉及的参考图谱的艰难梭菌菌株的存在。

    Method for the detection and identification of a variant C. difficile strain in a sample
    8.
    发明授权
    Method for the detection and identification of a variant C. difficile strain in a sample 有权
    用于检测和鉴定样品中艰难梭菌菌株变体的方法

    公开(公告)号：US08889363B2

    公开(公告)日：2014-11-18

    申请号：US12510013

    申请日：2009-07-27

    申请人： Veit Braun ,  Karina Gisch ,  Michael Moos ,  Christoph von Eichel-Streiber

    发明人： Veit Braun ,  Karina Gisch ,  Michael Moos ,  Christoph von Eichel-Streiber

    IPC分类号： G01N33/53 ,  G01N33/569 ,  C07K16/12

    CPC分类号： G01N33/56911 ,  C07K16/1282

    摘要： The method for detecting and identifying a variant C. difficile strain in a sample is characterized by the following steps: (a) obtaining a sample of excreta or tissue from a human or animal patient body; (b) bringing the sample into contact with at least one antibody from each of at least three of the antibody groups group I, group II, group III, group IV, group V and group VI; (c) detecting the antibody reaction and constructing the reaction pattern; (d) comparing the reaction pattern obtained in (c) with reference patterns from known C. difficile strains and C. difficile strains the presence of which is to be tested in the investigation test; (e) assessing the agreement between the reaction pattern obtained in (c) and the reference pattern as indicative of the presence of the C. difficile strain of the reference pattern concerned in the sample.

    摘要翻译： 用于检测和鉴定样品中艰难梭菌菌株的方法的特征在于以下步骤：（a）从人或动物患者体内获得排泄物或组织的样品; （b）使样品与至少三种抗体组I，II组，III组，IV组，V组和VI组中的至少一种抗体接触; （c）检测抗体反应并构建反应图; （d）将在（c）中获得的反应模式与来自已知艰难梭菌菌株和艰难梭菌菌株的参考样式进行比较，其中有待测试在调查试验中; （e）评估在（c）中获得的反应模式与参考模式之间的一致性，指示样品中涉及的参考图谱的艰难梭菌菌株的存在。