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公开(公告)号：US08927000B2
公开(公告)日：2015-01-06
申请号：US13173143
申请日：2011-06-30
CPC分类号： A61L29/085 , A61L29/044 , A61L29/14 , A61L29/145 , A61L29/16 , A61M2025/105 , C08L91/00
摘要： The present invention relates compositions for delivering therapeutic agents from a medical device including an expandable and collapsible structure and methods employing them. A lipid coating including one or more fatty acids increases the amount of therapeutic agent released from the device at the delivery site. The therapeutic agent can be in a matrix including a hydrophilic polymer or an amphiphilic polymer. Release and adhesion coatings can also facilitate delivery of therapeutic agent.
摘要翻译： 本发明涉及用于从包括可扩张和可折叠结构的医疗装置输送治疗剂的组合物和使用它们的方法。 包括一种或多种脂肪酸的脂质涂层增加了在递送部位从装置释放的治疗剂的量。 治疗剂可以是包括亲水性聚合物或两亲性聚合物的基质。 释放和粘附涂层也可以促进治疗剂的递送。
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公开(公告)号：US20120165786A1
公开(公告)日：2012-06-28
申请号：US13173143
申请日：2011-06-30
CPC分类号： A61L29/085 , A61L29/044 , A61L29/14 , A61L29/145 , A61L29/16 , A61M2025/105 , C08L91/00
摘要： The present invention relates compositions for delivering therapeutic agents from a medical device including an expandable and collapsible structure and methods employing them. A lipid coating including one or more fatty acids increases the amount of therapeutic agent released from the device at the delivery site. The therapeutic agent can be in a matrix including a hydrophilic polymer or an amphiphilic polymer. Release and adhesion coatings can also facilitate delivery of therapeutic agent.
摘要翻译： 本发明涉及用于从包括可扩张和可折叠结构的医疗装置输送治疗剂的组合物和使用它们的方法。 包括一种或多种脂肪酸的脂质涂层增加了在递送部位从装置释放的治疗剂的量。 治疗剂可以是包括亲水性聚合物或两亲性聚合物的基质。 释放和粘附涂层也可以促进治疗剂的递送。
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公开(公告)号：US09539079B2
公开(公告)日：2017-01-10
申请号：US14236425
申请日：2012-08-03
IPC分类号： A61F2/00
CPC分类号： A61F2/0045 , A61F2210/0057 , A61F2250/0007
摘要： Described are pelvic implants, systems including the implant and a delivery tool, and methods for the treatment of incontinence or prolapse. The implant has an expansion member associated with a support portion and a tensioning member along an extension portion of the implant. Systems and methods for treating incontinence or prolapse that include a composition having non-absorbable fibers of different sizes that can be applied to and set on an implant are also provided.
摘要翻译： 描述的是盆腔植入物，包括植入物和递送工具的系统，以及治疗失禁或脱垂的方法。 植入物具有沿着植入物的延伸部分与支撑部分和张紧构件相关联的扩张构件。 还提供了用于治疗失禁或脱垂的系统和方法，其包括具有不同尺寸的不可吸收纤维的组合物，其可以施用于植入物并设置在植入物上。
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4.发明申请HYDROPHOBIC POLYSACCHARIDES WITH PENDENT GROUPS HAVING TERMINAL REACTIVE FUNCTIONALITIES AND MEDICAL USES THEREOF 失效具有终端反应功能及其医疗用途的具有相关组的疏水性多糖公开(公告)号：US20120052107A9
公开(公告)日：2012-03-01
申请号：US12982214
申请日：2010-12-30
CPC分类号： C07H13/04 , A61L27/20 , A61L27/58 , A61L29/043 , A61L29/148 , A61L31/042 , A61L31/148
摘要： Hydrophobic α(1→4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic α(1→4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.
摘要翻译： 描述了可用于制备可植入或可注射医疗用品的疏水性α（1→4）吡喃葡萄糖聚合物。 疏水性α（1→4）吡喃葡萄糖聚合物包括具有烃基和末端胺或羟基的侧基。 可以由这些聚合物形成可生物降解的基质，并且该基质可用于制备可植入和可注射的医疗装置，其中基质能够在体内降解。 还描述了包括和能够在体内释放生物活性剂的基质。
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5.发明授权公开(公告)号：US08586731B2
公开(公告)日：2013-11-19
申请号：US12814109
申请日：2010-06-11
CPC分类号： A61K9/0024 , A61K47/36 , C08B30/18 , C08B37/0009
摘要： Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
摘要翻译： 描述了具有增强的降解性质的疏水性α（1-> 4）吡喃葡萄糖聚合物。 在α（1-> 4）吡喃葡萄糖聚合物部分和疏水部分之间存在具有促进聚合物降解的化学物质的连接部分。 二酯和碳酸酯接头化学品被列举。 可以由这些聚合物形成可生物降解的基质，并且该基质可用于制备可植入和可注射的医疗装置，其中基质能够以增加的速率在体内降解。 还描述了包括和能够在体内释放生物活性剂的基质。
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公开(公告)号：US20110318575A1
公开(公告)日：2011-12-29
申请号：US13171687
申请日：2011-06-29
IPC分类号： A61L27/34 , C08F220/22 , B32B3/00
CPC分类号： C08F226/10 , A61L27/16 , A61L29/085 , A61L31/10 , A61L2400/10 , A61M2025/0047 , C08F6/003 , C08F220/24 , C08F220/36 , C08F220/60 , Y10T428/1393 , Y10T428/265 , Y10T428/3154 , C08L27/12
摘要： The invention provides fluorinated polymeric articles formed a composition including a fluoropolymer. The fluoropolymer is formed using a fluorinated monomer that provides the fluoropolymer with most or all of the fluorine atoms not directly covalently attached to an atom of the fluoropolymer backbone. The fluoropolymer can also include a non-fluorinated hydrophilic monomer in a weight amount greater than the fluorinated monomer. The fluoropolymer composition also includes an ultraviolet light (UV)-reactive group capable of covalent bonding to promotes formation of the fluorinated polymeric article. The fluorinated polymeric article can be in the form of a durable lubricious coating on the surface of an implantable medical device. Coatings of the invention exhibit excellent wet/dry lubricity, durability, and controlled swelling.
摘要翻译： 本发明提供形成包含含氟聚合物的组合物的氟化聚合物制品。 使用氟化单体形成含氟聚合物，所述氟化单体提供含氟聚合物，其中大部分或全部氟原子不直接共价连接到含氟聚合物主链的原子上。 含氟聚合物还可以包括重量比氟化单体重量的非氟化亲水性单体。 含氟聚合物组合物还包括能够共价键合以促进氟化聚合物制品的形成的紫外线（UV） - 反应性基团。 氟化聚合物制品可以是在可植入医疗装置的表面上的持久润滑涂层的形式。 本发明的涂料表现出优异的湿/干润滑性，耐久性和受控的溶胀。
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7.发明申请HYDROPHOBIC POLYSACCHARIDES WITH PENDENT GROUPS HAVING TERMINAL REACTIVE FUNCTIONALITIES AND MEDICAL USES THEREOF 失效具有终端反应功能及其医疗用途的具有相关组的疏水性多糖公开(公告)号：US20110159067A1
公开(公告)日：2011-06-30
申请号：US12982214
申请日：2010-12-30
CPC分类号： C07H13/04 , A61L27/20 , A61L27/58 , A61L29/043 , A61L29/148 , A61L31/042 , A61L31/148
摘要： Hydrophobic α(1→4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic α(1→4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.
摘要翻译： 描述了可用于制备可植入或可注射医疗用品的疏水性α（1→4）吡喃葡萄糖聚合物。 疏水性α（1→4）吡喃葡萄糖聚合物包括具有烃基和末端胺或羟基的侧基。 可以由这些聚合物形成可生物降解的基质，并且该基质可用于制备可植入和可注射的医疗装置，其中基质能够在体内降解。 还描述了包括和能够在体内释放生物活性剂的基质。
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8.发明申请公开(公告)号：US20120082713A1
公开(公告)日：2012-04-05
申请号：US13248203
申请日：2011-09-29
CPC分类号： C08F20/36 , A61L29/085 , A61L29/14 , A61L2400/10
摘要： The invention provides polymers comprising pendent photochrome or near IR dye groups, as well as polymeric matrices made from these polymers, which can be used as or in association with a medical article. The polymers can be synthesized using methods that facilitate the preparation of medical articles having good biocompatibility. Exemplary polymeric matrices are in the form of lubricious coatings on medical devices, such as catheters. Visualization by irradiation of the photochrome or near IR dye can improve detection of the polymeric matrix on a device or in the body. This, in turn can improve aspects of a medical procedure, such as device insertion or matrix formation, as well as being useful for assessing the quality of the matrix.
摘要翻译： 本发明提供了包含侧基光色素或近红外染料基团的聚合物，以及由这些聚合物制成的聚合物基质，其可以作为或与医疗制品结合使用。 可以使用促进制备具有良好生物相容性的医疗制品的方法来合成聚合物。 示例性的聚合物基质是医疗装置如导管上的润滑涂层的形式。 通过照射光斑或靠近IR染料的可视化可以改善在装置或身体中的聚合物基质的检测。 这反过来可以改善诸如装置插入或矩阵形成之类的医疗过程的方面，并且可用于评估矩阵的质量。
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9.发明申请公开(公告)号：US20150018602A1
公开(公告)日：2015-01-15
申请号：US14236425
申请日：2012-08-03
IPC分类号： A61F2/00
CPC分类号： A61F2/0045 , A61F2210/0057 , A61F2250/0007
摘要： Described are pelvic implants, systems including the implant and a delivery tool, and methods for the treatment of incontinence or prolapse. The implant has an expansion member associated with a support portion and a tensioning member along an extension portion of the implant. Systems and methods for treating incontinence or prolapse that include a composition having non-absorbable fibers of different sizes that can be applied to and set on an implant are also provided.
摘要翻译： 描述的是盆腔植入物，包括植入物和递送工具的系统，以及治疗失禁或脱垂的方法。 植入物具有沿着植入物的延伸部分与支撑部分和张紧构件相关联的扩张构件。 还提供了用于治疗失禁或脱垂的系统和方法，其包括具有不同尺寸的不可吸收纤维的组合物，其可以施用于植入物并设置在植入物上。
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公开(公告)号：US08932694B2
公开(公告)日：2015-01-13
申请号：US13171687
申请日：2011-06-29
IPC分类号： A61M25/00 , C08F14/18 , C08F26/10 , C08F226/10 , A61L29/08 , C08F6/00 , A61L27/16 , A61L29/04 , A61L31/10 , C08F220/24 , C08F220/36 , C08F220/60
CPC分类号： C08F226/10 , A61L27/16 , A61L29/085 , A61L31/10 , A61L2400/10 , A61M2025/0047 , C08F6/003 , C08F220/24 , C08F220/36 , C08F220/60 , Y10T428/1393 , Y10T428/265 , Y10T428/3154 , C08L27/12
摘要： The invention provides fluorinated polymeric articles formed a composition including a fluoropolymer. The fluoropolymer is formed using a fluorinated monomer that provides the fluoropolymer with most or all of the fluorine atoms not directly covalently attached to an atom of the fluoropolymer backbone. The fluoropolymer can also include a non-fluorinated hydrophilic monomer in a weight amount greater than the fluorinated monomer. The fluoropolymer composition also includes an ultraviolet light (UV)-reactive group capable of covalent bonding to promotes formation of the fluorinated polymeric article. The fluorinated polymeric article can be in the form of a durable lubricious coating on the surface of an implantable medical device. Coatings of the invention exhibit excellent wet/dry lubricity, durability, and controlled swelling.
摘要翻译： 本发明提供形成包含含氟聚合物的组合物的氟化聚合物制品。 使用氟化单体形成含氟聚合物，所述氟化单体提供含氟聚合物，其中大部分或全部氟原子不直接共价连接到含氟聚合物主链的原子上。 含氟聚合物还可以包括重量比氟化单体重量的非氟化亲水性单体。 氟聚合物组合物还包括能够共价键合以促进氟化聚合物制品的形成的紫外线（UV） - 反应性基团。 氟化聚合物制品可以是在可植入医疗装置的表面上的持久润滑涂层的形式。 本发明的涂料表现出优异的湿/干润滑性，耐久性和受控的溶胀。
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