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    Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation
    1.
    发明授权
    Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation 失效
    疏水性多糖与含二酯或碳酸酯酯键具有增强的降解

    公开(公告)号：US08586731B2

    公开(公告)日：2013-11-19

    申请号：US12814109

    申请日：2010-06-11

    申请人： Dale G. Swan ,  Emily R. Rolfes Meyering ,  Aleksey V. Kurdyumov ,  Pamela J. Reed

    发明人： Dale G. Swan ,  Emily R. Rolfes Meyering ,  Aleksey V. Kurdyumov ,  Stephen J. Chudzik

    IPC分类号： C07H3/00 ,  A61F13/00

    CPC分类号： A61K9/0024 ,  A61K47/36 ,  C08B30/18 ,  C08B37/0009

    摘要： Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.

    摘要翻译： 描述了具有增强的降解性质的疏水性α（1-> 4）吡喃葡萄糖聚合物。 在α（1-> 4）吡喃葡萄糖聚合物部分和疏水部分之间存在具有促进聚合物降解的化学物质的连接部分。 二酯和碳酸酯接头化学品被列举。 可以由这些聚合物形成可生物降解的基质，并且该基质可用于制备可植入和可注射的医疗装置，其中基质能够以增加的速率在体内降解。 还描述了包括和能够在体内释放生物活性剂的基质。

    HYDROPHOBIC POLYSACCHARIDES WITH DIESTER- OR CARBONATE ESTER-CONTAINING LINKAGES HAVING ENHANCED DEGRADATION
    2.
    发明申请
    HYDROPHOBIC POLYSACCHARIDES WITH DIESTER- OR CARBONATE ESTER-CONTAINING LINKAGES HAVING ENHANCED DEGRADATION 失效
    具有增强降解性的含有碳酸钙或含碳酸酯的链接的疏水性多糖

    公开(公告)号：US20100316687A1

    公开(公告)日：2010-12-16

    申请号：US12814109

    申请日：2010-06-11

    申请人： Dale G. Swan ,  Emily R. Rolfes Meyering ,  Aleksey V. Kurdyumov ,  Stephen J. Chudzik ,  Pamela J. Reed

    发明人： Dale G. Swan ,  Emily R. Rolfes Meyering ,  Aleksey V. Kurdyumov ,  Stephen J. Chudzik ,  Pamela J. Reed

    IPC分类号： A61K9/10 ,  C07H3/06

    CPC分类号： A61K9/0024 ,  A61K47/36 ,  C08B30/18 ,  C08B37/0009

    摘要： Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.

    摘要翻译： 描述了具有增强的降解性质的疏水性α（1→4）吡喃葡萄糖聚合物。 在α（1→4）吡喃葡萄糖聚合物部分和疏水部分之间存在具有促进聚合物降解的化学物质的接头部分。 二酯和碳酸酯接头化学品被列举。 可以由这些聚合物形成可生物降解的基质，并且该基质可用于制备可植入和可注射的医疗装置，其中基质能够以增加的速率在体内降解。 还描述了包括和能够在体内释放生物活性剂的基质。

    Ligand-coupled initiator polymers and methods of use
    3.
    发明授权
    Ligand-coupled initiator polymers and methods of use 有权
    配体偶联的引发剂聚合物和使用方法

    公开(公告)号：US07820158B2

    公开(公告)日：2010-10-26

    申请号：US10412063

    申请日：2003-04-10

    申请人： Stephen J. Chudzik ,  Dale G. Swan

    发明人： Stephen J. Chudzik ,  Dale G. Swan

    IPC分类号： A61K9/50 ,  C12N5/00 ,  C12N11/04

    CPC分类号： A61K9/5026 ,  A61K9/1635 ,  A61K47/32 ,  Y10S516/911 ,  Y10S522/904 ,  Y10S623/92

    摘要： Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic β cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.

    摘要翻译： 提供了具有引发剂基团和配体基团的引发剂聚合物。 引发剂聚合物能够特异性结合表面上的受体。 使用大分子单体体系，引发剂聚合物可用于在材料表面上形成聚合物基质。 特别地，提供对胰腺特异性的引发剂聚合物; 细胞，可用于包封细胞进行移植和治疗糖尿病。

    LIGAND-COUPLED INITIATOR POLYMERS AND METHODS OF USE
    6.
    发明申请
    LIGAND-COUPLED INITIATOR POLYMERS AND METHODS OF USE 审中-公开
    配体联合发射体聚合物及其使用方法

    公开(公告)号：US20110040057A1

    公开(公告)日：2011-02-17

    申请号：US12911578

    申请日：2010-10-25

    申请人： Stephen J. Chudzik ,  Dale G. Swan

    发明人： Stephen J. Chudzik ,  Dale G. Swan

    IPC分类号： C08F124/00 ,  C08F128/02 ,  C08G18/71

    CPC分类号： A61K9/5026 ,  A61K9/1635 ,  A61K47/32 ,  Y10S516/911 ,  Y10S522/904 ,  Y10S623/92

    摘要： Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic β cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.

    摘要翻译： 提供了具有引发剂基团和配体基团的引发剂聚合物。 引发剂聚合物能够特异性结合表面上的受体。 使用大分子单体体系，引发剂聚合物可用于在材料表面上形成聚合物基质。 特别地，提供对胰腺特异性的引发剂聚合物; 细胞，可用于包封细胞进行移植和治疗糖尿病。

    Reagent and method for providing coatings on surfaces
    7.
    发明授权
    Reagent and method for providing coatings on surfaces 有权
    用于在表面上提供涂层的试剂和方法

    公开(公告)号：US07348055B2

    公开(公告)日：2008-03-25

    申请号：US10028518

    申请日：2001-12-21

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： B32B27/00

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    Reagent and method for providing coatings on surfaces
    9.
    发明授权
    Reagent and method for providing coatings on surfaces 失效
    用于在表面上提供涂层的试剂和方法

    公开(公告)号：US08039524B2

    公开(公告)日：2011-10-18

    申请号：US12783907

    申请日：2010-05-20

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Pam Read, legal representative ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： C08F2/50

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。