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1.发明授权公开(公告)号：US07470232B2
公开(公告)日：2008-12-30
申请号：US10838799
申请日：2004-05-04
申请人： Ralph T. Hoctor , Kai E. Thomenius
发明人： Ralph T. Hoctor , Kai E. Thomenius
IPC分类号： A61B8/00
CPC分类号： A61B8/0866 , A61B8/02 , A61B8/08 , A61B8/4236 , A61B8/4483 , A61B8/488 , B06B1/0292
摘要： A continuous, non-invasive fetal heart rate measurement is produced using one or more ultrasonic transducer array patches that are adhered or attached to the mother. Each ultrasound transducer array is operated in an autonomous mode by a digital signal processor to obtain data from which fetal heart rate information can be derived. Each ultrasonic transducer array patch comprises a multiplicity of subelements that are switchably reconfigurable to form elements having different shapes, e.g., annular rings. Each subelement comprises a plurality of interconnected cMUT cells that are not switchably disconnectable. The use of cMUT patches will provide the ability to interrogate a three-dimensional space electronically (i.e. without mechanical beam steering) with ultrasound, using a transducer device that is thin and lightweight enough to stick to the patient's skin like an EKG electrode. The ultrasound device can track the fetal heart in three-dimensional space as it moves due to the mother's motion or the motion of the unborn child within the womb.
摘要翻译： 使用粘附或附着到母亲的一个或多个超声换能器阵列贴片产生连续的非侵入性胎儿心率测量。 每个超声换能器阵列通过数字信号处理器在自主模式下操作以获得可以从其导出胎儿心率信息的数据。 每个超声波换能器阵列贴片包括多个子元件，其可切换地可重构以形成具有不同形状的元件，例如环形环。 每个子元件包括不可切换地断开的多个互连的cMUT单元。 使用cMUT贴片将提供以超声波电子方式询问三维空间的能力（即，不使用机械光束转向），该传感器装置足够薄且足够轻以抵抗患者的皮肤，如EKG电极。 超声波装置可以在三维空间跟踪胎儿的心脏，因为母亲的运动或未出生子女在子宫内的运动。
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2.发明申请METHOD AND APPARATUS FOR NON-INVASIVE ULTRASONIC FETAL HEART RATE MONITORING 审中-公开非侵入式超声心动图监测的方法和装置公开(公告)号：US20080208057A1
公开(公告)日：2008-08-28
申请号：US12110901
申请日：2008-04-28
申请人： Ralph T. Hoctor , Kai E. Thomenius
发明人： Ralph T. Hoctor , Kai E. Thomenius
IPC分类号： A61B8/02
CPC分类号： A61B8/0866 , A61B8/02 , A61B8/08 , A61B8/4236 , A61B8/4483 , A61B8/488 , B06B1/0292
摘要： A continuous, non-invasive fetal heart rate measurement is produced using one or more ultrasonic transducer array patches that are adhered or attached to the mother. Each ultrasound transducer array is operated in an autonomous mode by a digital signal processor to obtain data from which fetal heart rate information can be derived. Each ultrasonic transducer array patch comprises a multiplicity of subelements that are switchably reconfigurable to form elements having different shapes, e.g., annular rings. Each subelement comprises a plurality of interconnected cMUT cells that are not switchably disconnectable. The use of cMUT patches will provide the ability to interrogate a three-dimensional space electronically (i.e. without mechanical beam steering) with ultrasound, using a transducer device that is thin and lightweight enough to stick to the patient's skin like an EKG electrode. The ultrasound device can track the fetal heart in three-dimensional space as it moves due to the mother's motion or the motion of the unborn child within the womb.
摘要翻译： 使用粘附或附着到母亲的一个或多个超声换能器阵列贴片产生连续的非侵入性胎儿心率测量。 每个超声换能器阵列通过数字信号处理器在自主模式下操作以获得可以从其导出胎儿心率信息的数据。 每个超声波换能器阵列贴片包括多个子元件，其可切换地可重构以形成具有不同形状的元件，例如环形环。 每个子元件包括不可切换地断开的多个互连的cMUT单元。 使用cMUT贴片将提供以超声波电子方式询问三维空间的能力（即，不使用机械光束转向），该传感器装置足够薄且足够轻以抵抗患者的皮肤，如EKG电极。 超声波装置可以在三维空间跟踪胎儿的心脏，因为母亲的运动或未出生子女在子宫内的运动。
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3.发明授权Method and apparatus for ultrasonic continuous, non-invasive blood pressure monitoring 有权用于超声波连续，无创血压监测的方法和装置公开(公告)号：US07125383B2
公开(公告)日：2006-10-24
申请号：US10749181
申请日：2003-12-30
CPC分类号： A61B8/04 , A61B8/4236
摘要： Ultrasound is used to provide input data for a blood pressure estimation scheme. The use of transcutaneous ultrasound provides arterial lumen area and pulse wave velocity information. In addition, ultrasound measurements are taken in such a way that all the data describes a single, uniform arterial segment. Therefore a computed area relates only to the arterial blood volume present. Also, the measured pulse wave velocity is directly related to the mechanical properties of the segment of elastic tube (artery) for which the blood volume is being measured. In a patient monitoring application, the operator of the ultrasound device is eliminated through the use of software that automatically locates the artery in the ultrasound data, e.g., using known edge detection techniques. Autonomous operation of the ultrasound system allows it to report blood pressure and blood flow traces to the clinical users without those users having to interpret an ultrasound image or operate an ultrasound imaging device.
摘要翻译： 超声波用于提供血压估计方案的输入数据。 使用经皮超声提供动脉管腔面积和脉搏波速度信息。 另外，以这样的方式进行超声测量，使得所有数据描述单个均匀的动脉段。 因此，计算区域仅与存在的动脉血容量相关。 此外，测量的脉搏波速度与测量血容量的弹性管（动脉）的段的机械性质直接相关。 在患者监视应用中，例如使用已知的边缘检测技术，通过使用自动将动脉定位在超声数据中的软件来消除超声装置的操作者。 超声系统的自主操作允许它向临床用户报告血压和血流迹线，而不需要用户解释超声图像或操作超声成像装置。
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公开(公告)号：US08043223B2
公开(公告)日：2011-10-25
申请号：US11562489
申请日：2006-11-22
IPC分类号： A61B5/02
CPC分类号： A61B5/02416 , A61B5/02007 , A61B5/02125 , A61B5/022 , A61B5/14551 , A61B8/06 , A61B8/4227
摘要： A method and system for use in measuring the endothelial dysfunction utilizing flow mediated dilation and determining arterial health of a patient. The system includes a non-invasive blood pressure monitor, an ultrasound system and a pulse oximeter monitor that all communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer, blood pressure cuff and pulse oximeter sensor are positioned on an arm of the patient. The blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining a parameter of the artery, such as diameter, and the flow rate of blood through the artery without any operator intervention. At the same time, the pulse wave velocity PWV is calculated between the ultrasound transducer and the finger probe of the pulse oximeter following the occlusion period. Based upon the detected characteristics of the artery before and after occlusion, as well as the PWV, the system can determine the endothelial dysfunction and arterial health of the patient.
摘要翻译： 用于利用流介导的扩张和确定患者的动脉健康来测量内皮功能障碍的方法和系统。 该系统包括无创血压监测器，超声波系统和脉搏血氧计监测器，它们彼此通信以进行流量介导的扩张。 最初，超声波换能器，血压袖带和脉搏血氧饱和度传感器位于患者的手臂上。 血压袖带充气以闭塞动脉以阻塞期。 在闭塞期之后，自动发信号通知超声系统以开始确定动脉的参数，例如直径，以及血液通过动脉的流速，无需任何操作者干预。 同时，在闭塞期之后，在超声换能器和脉搏血氧计的手指探针之间计算出脉搏波速度PWV。 根据检测到的阻塞前后动脉的特征以及PWV，系统可以确定患者的内皮功能障碍和动脉健康。
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公开(公告)号：US4395910A
公开(公告)日：1983-08-02
申请号：US189730
申请日：1980-09-22
申请人： Kai E. Thomenius
发明人： Kai E. Thomenius
CPC分类号： G01S7/52063 , G01N29/0627 , G01N29/0645 , G01R13/20 , G01S7/5205
摘要： Circuitry for generating a distortion-free sector display in a cathode ray tube for displaying signals from an ultrasonic transducer moving back and forth in an arcuate path. Sine and cosine beam sweep signals are developed using signals respectively representing the angular position .theta. of the transducer on its angular path (representing the sine) and 1-.theta..sup.2 /2(representing the cosine). A transducer position signal is stored on a relatively large capacitor, and a capacitor of smaller capacitance is used to generate a ramp signal in producing the sine and cosine beam sweep signals.
摘要翻译： 用于在阴极射线管中产生无失真扇区显示的电路，用于显示来自在弧形路径中来回移动的超声波换能器的信号。 使用分别表示换能器在其角度路径（表示正弦）和1θ2/2（表示余弦）上的角度位置θ的信号来开发正弦和余弦波束扫描信号。 换能器位置信号存储在相对较大的电容器上，并且使用较小电容的电容器来产生斜波信号以产生正弦和余弦波束扫描信号。
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公开(公告)号：US08016761B2
公开(公告)日：2011-09-13
申请号：US11551749
申请日：2006-10-23
IPC分类号： A61B5/02
CPC分类号： A61B8/06 , A61B5/02007 , A61B5/022 , A61B8/4227
摘要： A method and system for use in measuring the endothelial dysfunction in a patient utilizing flow mediated dilation. The system includes both a non-invasive blood pressure monitor and an ultrasound system that communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer and blood pressure cuff are positioned on an arm of the patient and the blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining both the diameter of the artery and the flow rate of blood through the artery without any operator intervention. Based upon the detected characteristics of the artery before and after occlusion, the system can determine the endothelial dysfunction of the patient.
摘要翻译： 用于测量利用流介导扩张的患者内皮功能障碍的方法和系统。 该系统包括无创血压监测器和彼此通信以执行流动介导的扩张的超声系统。 最初，将超声波换能器和血压袖带放置在患者的手臂上，使血压袖带充气以阻塞动脉以阻塞闭塞期。 在闭塞期之后，超声系统自动发出信号，开始确定动脉直径和通过动脉的血液流速，无需任何操作者干预。 根据检测到阻塞前后的动脉特征，系统可以确定患者的内皮功能障碍。
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公开(公告)号：US20080119743A1
公开(公告)日：2008-05-22
申请号：US11551749
申请日：2006-10-23
IPC分类号： A61B5/02
CPC分类号： A61B8/06 , A61B5/02007 , A61B5/022 , A61B8/4227
摘要： A method and system for use in measuring the endothelial dysfunction in a patient utilizing flow mediated dilation. The system includes both a non-invasive blood pressure monitor and an ultrasound system that communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer and blood pressure cuff are positioned on an arm of the patient and the blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining both the diameter of the artery and the flow rate of blood through the artery without any operator intervention. Based upon the detected characteristics of the artery before and after occlusion, the system can determine the endothelial dysfunction of the patient.
摘要翻译： 用于测量利用流介导扩张的患者内皮功能障碍的方法和系统。 该系统包括无创血压监测器和彼此通信以执行流动介导的扩张的超声系统。 最初，将超声波换能器和血压袖带放置在患者的手臂上，使血压袖带充气以阻塞动脉以阻塞闭塞期。 在闭塞期之后，超声系统自动发出信号，开始确定动脉直径和通过动脉的血液流速，无需任何操作者干预。 根据检测到阻塞前后的动脉特征，系统可以确定患者的内皮功能障碍。
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公开(公告)号：US4208916A
公开(公告)日：1980-06-24
申请号：US941919
申请日：1978-09-13
CPC分类号： G10K11/341 , G01N29/06 , G01S7/52063 , G01N2291/0289
摘要： An electronically scanned phased array diagnostic system for describing internal structure of a subject by the use of ultrasonic energy. The system includes a transducer unit with an array of ultrasonic energy conversion segments and control circuitry for actuating the segments to direct ultrasonic energy into the subject. Imaging circuitry is included for interpreting electrical return signals produced by the segments in response to ultrasonic echoes. The imaging circuitry includes transmission delay circuits for imposing time delays on the return signals for steering and focusing system echo reception. Each transmission delay circuit includes first and second delay elements for impressing first and second delay time components on the return signals. Each pair of the first delay elements are coupled in parallel with separate transducer elements, and serially combined with a downstream second delay element.The first delay elements provide a portion of the reception steering capability. The second elements provide the remainder of the steering, and the beam focusing, delay components. The system further includes display apparatus responsive to the delayed return signals for producing an image of the subjects internal structure.
摘要翻译： 一种电子扫描相控阵诊断系统，用于通过使用超声波能量来描述受试者的内部结构。 该系统包括具有超声能量转换段的阵列的传感器单元和用于致动段以将超声波能量引导到对象中的控制电路。 包括成像电路，用于解释由响应于超声回波的段产生的电返回信号。 成像电路包括用于对用于转向和聚焦系统回波接收的返回信号施加时间延迟的传输延迟电路。 每个传输延迟电路包括用于在返回信号上施加第一和第二延迟时间分量的第一和第二延迟元件。 每对第一延迟元件与单独的换能器元件并联耦合，并且与下游第二延迟元件串联组合。 第一延迟元件提供接收转向能力的一部分。 第二个元件提供了转向的其余部分，以及光束聚焦，延迟部件。 该系统还包括响应于延迟返回信号的显示装置，用于产生被摄体内部结构的图像。
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9.发明授权Transmit and receive interface array for highly integrated ultrasound scanner 有权发射和接收接口阵列，用于高度集成的超声波扫描仪公开(公告)号：US07775979B2
公开(公告)日：2010-08-17
申请号：US11172599
申请日：2005-06-29
IPC分类号： A61B8/00
CPC分类号： G10K11/341 , A61B8/56 , G01S7/5208
摘要： An ultrasonic transducer probe having a highly integrated interface circuit array. Low-voltage transmit control signals from the system are transmitted on the system transmit channels via the ultrasound probe cable and into the interface circuit array. These transmit control signals are routed through the interface circuit array using a dense switching matrix. Once the low-voltage transmit control signals reach individual cells within the interface array, they are decoded and used to control local high-voltage pulser circuits to drive individual ultrasound transducer elements made up of selected subelements that are co-integrated with the interface electronics. The interface cell circuitry further comprises a high-voltage transmit/receive switch, which is closed when the high-voltage pulser is transmitting to protect the low-voltage components.
摘要翻译： 具有高度集成的接口电路阵列的超声换能器探针。 来自系统的低电压发射控制信号通过超声探头电缆在系统发射通道上传输到接口电路阵列中。 这些发送控制信号使用密集的交换矩阵通过接口电路阵列路由。 一旦低压发射控制信号到达接口阵列内的单个小区，就将它们解码并用于控制本地高压脉冲发生器电路，以驱动由与接口电子器件共同集成的选定子元件组成的各个超声换能器元件。 接口单元电路还包括高压发射/接收开关，当高压脉冲发生器正在传输时，该高压发射/接收开关闭合以保护低电压部件。
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10.发明授权Optimized switching configurations for reconfigurable arrays of sensor elements 失效用于可重构阵列传感器元件的优化开关配置公开(公告)号：US07353056B2
公开(公告)日：2008-04-01
申请号：US10978175
申请日：2004-10-29
申请人： Christopher Robert Hazard , Robert Gideon Wodnicki , Rayette Ann Fisher , Kai E. Thomenius , Lowell Scott Smith , David Martin Mills
发明人： Christopher Robert Hazard , Robert Gideon Wodnicki , Rayette Ann Fisher , Kai E. Thomenius , Lowell Scott Smith , David Martin Mills
CPC分类号： G10K11/34 , A61B2562/028 , B06B1/0292 , G01S7/52046 , G01S15/8925
摘要： The reconfigurable ultrasound array disclosed herein is one that allows groups of subelements to be connected together dynamically so that the shape of the resulting element can be made to match the shape of the wave front. This can lead to improved performance and/or reduced channel count. Reconfigurability can be achieved using a switching network. A methodology and an algorithm are disclosed that allows the performance of this switching network to be improved by properly choosing the configuration of the switching network.
摘要翻译： 本文公开的可重构超声波阵列是允许一组子元件动态地连接在一起的结构，使得所得元件的形状可以与波前的形状相匹配。 这可以导致改进的性能和/或减少的通道数。 可以使用交换网络实现可重构性。 公开了一种通过适当选择交换网络的配置来改善该交换网络的性能的方法和算法。
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