公开(公告)号：US20140140968A1

公开(公告)日：2014-05-22

申请号：US14164286

申请日：2014-01-27

Applicant: BrainStorm Cell Therapeutics Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Avinoam KADOURI ,  Avihay BAR-ILAN ,  Eldad MELAMED ,  Daniel OFFEN ,  Ofer SADAN ,  Merav BAHAT-STROMZA

IPC: C12N5/0775 ,  A61K38/18

CPC classification number: A61K38/185 ,  A61K35/12 ,  A61K35/28 ,  C12N5/0618 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N5/0669 ,  C12N2500/84 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2506/1353

Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.

Abstract translation: 公开了一种分离的人细胞，其包含至少一种间充质干细胞表型和分泌性脑源性神经营养因子（BDNF），其中BDNF的基础分泌比间充质干细胞中BDNF的基础分泌高至少五倍 。 还公开了生产方法及其使用方法。

公开(公告)号：US20160375098A1

公开(公告)日：2016-12-29

申请号：US15261959

申请日：2016-09-11

Applicant: Ramot at Tel-Aviv University Ltd. ,  BrainStorm Cell Therapeutics Ltd.

Inventor： Avinoam KADOURI ,  Avihay BAR-ILAN ,  Eldad MELAMED ,  Daniel OFFEN ,  Ofer SADAN ,  Merav BAHAT-STROMZA

IPC: A61K38/18

CPC classification number: A61K38/185 ,  A61K35/12 ,  A61K35/28 ,  C12N5/0618 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N5/0669 ,  C12N2500/84 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2506/1353

Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.

公开(公告)号：US20180333458A1

公开(公告)日：2018-11-22

申请号：US16047129

申请日：2018-07-27

Applicant: Ramot at Tel-Aviv University Ltd. ,  BrainStorm Cell Therapeutics Ltd.

Inventor： Avinoam KADOURI ,  Avihay BAR-ILAN ,  Eldad MELAMED ,  Daniel OFFEN ,  Ofer SADAN ,  Merav BAHAT-STROMZA

IPC: A61K38/18 ,  C12N5/0775 ,  A61K35/28 ,  C12N5/079 ,  A61K35/12 ,  C12N5/077

CPC classification number: A61K38/185 ,  A61K35/12 ,  A61K35/28 ,  C12N5/0618 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N5/0669 ,  C12N2500/84 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2506/1353

Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.

公开(公告)号：US20180112185A1

公开(公告)日：2018-04-26

申请号：US15820521

申请日：2017-11-22

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Daniel OFFEN ,  Merav BAHAT-STROMZA ,  Eldad MELAMED

IPC: C12N5/077 ,  C12N5/079

CPC classification number: A61K35/28 ,  A61K35/30 ,  C12N5/0622 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/40 ,  C12N2506/1353

Abstract: An isolated human cell and populations thereof is provided comprising at least one astrocytic phenotype and at least one mesenchymal stem cell phenotype, wherein the mesenchymal stem cell phenotype is not an astrocytic phenotype.