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公开(公告)号：US20130158625A1
公开(公告)日：2013-06-20
申请号：US13529770
申请日：2012-06-21
申请人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
发明人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/3611 , A61N1/36171
摘要： A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.
摘要翻译： 一种通过刺激呼吸肌或神经夹带呼吸系统同时使呼吸驱动完好无损来治疗呼吸障碍的手段。 本发明的实施例采用频率分析来确定是否正在施加适当的刺激能量。
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公开(公告)号：US08433412B1
公开(公告)日：2013-04-30
申请号：US12367024
申请日：2009-02-06
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61N1/05 , A61N1/0551 , A61N1/056 , A61N1/3611 , A61N1/36139 , A61N1/36521 , A61N1/36542 , A61N1/37 , A61N1/3962 , A61N2001/0585
摘要： A lead system for an implantable medical device and applications for the lead system. Also includes therapeutic systems, devices, and processes for detecting and treating disordered breathing and treating cardiac and breathing issues together with an implantable device.
摘要翻译： 用于可植入医疗设备的引导系统和引导系统的应用。 还包括用于检测和处理无序呼吸并与可植入装置一起治疗心脏和呼吸问题的治疗系统，装置和方法。
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公开(公告)号：US09999768B2
公开(公告)日：2018-06-19
申请号：US13529770
申请日：2012-06-21
申请人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
发明人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/3611 , A61N1/36171
摘要： A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.
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公开(公告)号：US08233987B2
公开(公告)日：2012-07-31
申请号：US12557084
申请日：2009-09-10
申请人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
发明人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/3611 , A61N1/36171
摘要： A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.
摘要翻译： 一种通过刺激呼吸肌或神经夹带呼吸系统同时使呼吸驱动完好无损来治疗呼吸障碍的手段。 本发明的实施例采用频率分析来确定是否正在施加适当的刺激能量。
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公开(公告)号：US20110060380A1
公开(公告)日：2011-03-10
申请号：US12557084
申请日：2009-09-10
申请人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
发明人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
CPC分类号： A61N1/3601 , A61N1/3611 , A61N1/36171
摘要： A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.
摘要翻译： 一种通过刺激呼吸肌或神经夹带呼吸系统同时使呼吸驱动完好无损来治疗呼吸障碍的手段。 本发明的实施例采用频率分析来确定是否正在施加适当的刺激能量。
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公开(公告)号：US10406366B2
公开(公告)日：2019-09-10
申请号：US12150654
申请日：2008-04-30
申请人： Randy W. Westlund , Mark Gelfand
发明人： Randy W. Westlund , Mark Gelfand
摘要： A lead system and method of use for treating breathing disorders by the transvenous stimulation of the phrenic nerve. The lead is implanted in a vein near one portion of the phrenic nerve.
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公开(公告)号：US20090036947A1
公开(公告)日：2009-02-05
申请号：US12150654
申请日：2008-04-30
申请人： Randy W. Westlund , Mark Gelfand
发明人： Randy W. Westlund , Mark Gelfand
CPC分类号： A61N1/3611 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/3601 , A61N1/3684
摘要： A lead system and method of use for treating breathing disorders by the transvenous stimulation of the phrenic nerve.
摘要翻译： 用于通过膈神经的经静脉刺激来治疗呼吸障碍的引导系统和方法。
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公开(公告)号：US20190000545A1
公开(公告)日：2019-01-03
申请号：US16019380
申请日：2018-06-26
申请人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
发明人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/14 , A61N7/02 , A61F7/12 , A61M5/142 , A61M5/172 , A61N1/28 , A61N1/32 , A61N1/36 , A61N1/40 , A61N5/04 , A61B18/00 , A61N7/00 , A61N1/362
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
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公开(公告)号：US20150282877A1
公开(公告)日：2015-10-08
申请号：US14737254
申请日：2015-06-11
申请人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
发明人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
CPC分类号： A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61F7/123 , A61F2007/126 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/28 , A61N1/32 , A61N1/326 , A61N1/36007 , A61N1/36017 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/403 , A61N5/045 , A61N7/02 , A61N2007/003
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
摘要翻译： 提供了用于热诱导的肾神经调节的方法和装置。 热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。 在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。 在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。 在一些实施方案中，热诱导的肾神经调节通过脉冲热疗法的递送来实现。
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公开(公告)号：US20140324016A1
公开(公告)日：2014-10-30
申请号：US14221536
申请日：2014-03-21
申请人： Mark Gelfand , Howard R. Levin
发明人： Mark Gelfand , Howard R. Levin
CPC分类号： A61K31/529 , A61K9/0004 , A61K9/0012 , A61K9/7007 , A61K31/135 , A61K31/52 , A61K45/06 , A61L29/146 , A61M5/14276 , A61M5/145 , A61M5/1723 , A61M2005/14513 , A61M2205/05 , A61M2205/50 , A61M2210/1082 , A61N1/0551 , A61N1/326 , A61N1/36007 , A61N1/36114 , A61N1/36117 , A61N1/3627
摘要： A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluding implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.
摘要翻译： 一种用于通过植入用于阻断肾脏和/或从肾脏的肾神经信号的装置来治疗与交感神经肾神经活动升高相关的心脏和肾脏疾病的方法和装置。 该装置可以是药物泵或药物迂回植入物，用于将神经阻断剂靶向递送至肾动脉的动脉周围空间。
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